Post-hospital outcome following intensive care
Clinical Intensive CarePublished 1 June 1995
Robert T. Brooks, Adrian Bauman, Katharine Daffurn, Ken Hillman
Citations24
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
Abstract
(1995). Post-hospital outcome following intensive care. Clinical Intensive Care: Vol. 6, No. 3, pp. 127-127.
Keywords
Biochemistry, Genetics and Molecular BiologyMedicineNursing
New England Journal of MedicineThe Inverse Relation between Fish Consumption and 20-Year Mortality from Coronary Heart Disease
2,186 Citations1985Daan Kromhout, Edward B. Bosschieter +1 more
It is concluded that the consumption of as little as one or two fish dishes per week may be of preventive value in relation to coronary heart disease.
American Journal of Clinical NutritionOmega-3 fatty acids in health and disease and in growth and development
2,167 Citations1991AP Simopoulos
Omega 3 fatty acids decrease the number and size of tumors and increase the time elapsed before appearance of tumors, which is essential for the normal functional development of the retina and brain, particularly in premature infants.
New England Journal of MedicineThe Effect of Dietary Supplementation with n—3 Polyunsaturated Fatty Acids on the Synthesis of Interleukin-1 and Tumor Necrosis Factor by Mononuclear Cells
1,923 Citations1989Stefan Endres, Reza Ghorbani +11 more
Nine healthy volunteers added 18 g of fish-oil concentrate per day to their normal Western diet for six weeks to examine whether the synthesis of interleukin-1 or tumor necrosis factor, two cytokines with potent inflammatory activities, is influenced by dietary supplementation with n—3 fatty acids.
New England Journal of MedicineEffect of Dietary Enrichment with Eicosapentaenoic and Docosahexaenoic Acids on in Vitro Neutrophil and Monocyte Leukotriene Generation and Neutrophil Function
1,339 Citations1985TH Lee, Richard L. Hoover +8 more
The effects of dietary fish-oil fatty acids on the function of the 5-lipoxygenase pathway of peripheral-blood polymorphonuclear leukocytes and monocytes were determined in seven normal subjects who supplemented their usual diet with daily doses of triglycerides.
The LancetHÆMOSTATIC FUNCTION AND PLATELET POLYUNSATURATED FATTY ACIDS IN ESKIMOS
1,005 Citations1979J. Dyerberg, H. O. Bang
Partial dietary substitution of arachidonic acid by eicosapentaenoic acid may reduce the incidence of thrombotic disorders, including myocardial infarction, among Eskimos.
American Journal of Clinical NutritionFatty acid composition of the plasma lipids in Greenland Eskimos
881 Citations1975J. Dyerberg, HO Bang +1 more
If dietary differences are the main reason for the differences in plasma lipid concentrations, the results from the present study point more toward qualitative than toward quantitative differences in respect of fatty acid composition of the food.
Journal of Clinical InvestigationLong-term effects of dietary marine omega-3 fatty acids upon plasma and cellular lipids, platelet function, and eicosanoid formation in humans.
613 Citations1985Clemens von Schacky, Sven Fischer +1 more
NatureProstaglandin I3 is formed in vivo in man after dietary eicosapentaenoic acid
472 Citations1984Sven Fischer, Peter C. Weber
It is shown here that the major urinary metabolite of endogenous prostaglandin I3 is present in subjects that have ingested either cod liver oil or mackerel, and provides the first direct evidence for in vivo formation of prostaglandsin I2 in man.
The LancetA DOUBLE-BLIND, RANDOMISED, PLACEBO-CONTROLLED TRIAL OF FISH OIL IN PSORIASIS
328 Citations1988S.B. Bittiner
After 8 weeks' treatment there was a significant lessening of itching, erythema, and scaling in the active treatment group, with a trend towards an overall decrease in body surface area affected.
Journal of Immunological MethodsA rapid method for purification of human granulocytes using percoll®. A comparison with dextran sedimentation
277 Citations1981Rolf Hjorth, Anna-Karin Jonsson +1 more
It is concluded that centrifugation in Percoll is superior to conventional dextran sedimentation; it is also less time-consuming.
PubMedFish oil fatty acid supplementation in active ulcerative colitis: a double-blind, placebo-controlled, crossover study.
247 Citations1992Abdullah Nabi Aslan, George Triadafilopoulos
It is concluded that fish oil dietary supplementation results in clinical improvement of active mild to moderate ulcerative colitis but is not associated with significant reduction in mucosal leukotriene B4 production, compared with placebo therapy.
Journal of Clinical ImmunologyAlterations in human leukocyte function induced by ingestion of eicosapentaenoic acid
165 Citations1986Donald G. Payan, Michael Y. Wong +6 more
Two groups of six adults with persistent asthma, who were identical clinically, received 0.1 or 4 g of purified eicosapentaenoic acid ethyl ester daily for 8 weeks, and both doses of EPA increased the responses of T lymphocytes to phytohemagglutinin by a mean of 73% or more without modifying the numbers of helper and suppressor T lymphocyte.
Proceedings of the National Academy of SciencesLeukotriene B5 is formed in human neutrophils after dietary supplementation with icosapentaenoic acid.
144 Citations1985Thomas Strasser, Sven Fischer +1 more
It is proved that LTB5, which is 10 to 30 times less potent than LTB4 to cause aggregation, chemotaxis, and degranulation of PMNL, can be formed in vivo in man after dietary icosapentaenoic acid.
Intensive Care MedicineRole of thromboxane, prostaglandins and leukotrienes in endotoxic and septic shock
138 Citations1986H. A. Ball, James A. Cook +2 more
The hypothesis that TxA2 exerts a pathophysiologic effect in shock following bolus endotoxin is supported and the results suggest that some other cyclooxygenase product(s) is involved in septic shock due to fecal peritonitis or cecal ligation.
CirculationVascular prostacyclin is increased in patients ingesting omega-3 polyunsaturated fatty acids before coronary artery bypass graft surgery.
135 Citations1990R. DeCaterina, Daniela Giannessi +7 more
Omega-3 PUFAs at moderate dosages may exert antithrombotic effects by increasing prostacyclin production by vessel walls as well as by direct inhibition of platelet activity, as indicated by increased levels of 6-keto-PGF1 alpha.
Naunyn-Schmiedeberg s Archives of PharmacologyLeukotrienes C4, D4 and E4 cause widespread and extensive plasma extravasation in the guinea pig
134 Citations1985Xiaoyang Hua, S.-E. Dahl�n +3 more
It is concluded that the three major constituents of slow reacting substance of anaphylaxis (SRS-A), leukotrienes C4, D4 and E4, cause a generalized and extensive plasma exudation that is consistent with the proposal that these leukOTrienes are important mediators of inflammation.
The Journal of ImmunologyThe effects of N-3 polyunsaturated fatty acids on the generation of platelet-activating factor-acether by human monocytes.
133 Citations1987Richard I. Sperling, J L Robin +4 more
Whether added to the diet or introduced in vitro, fish oil-derived fatty acids suppress PAF-acether generation by human monocyte monolayers.
American Journal of Physiology-Heart and Circulatory PhysiologyEstimation of the filtration coefficient of pulmonary exchange vessels
129 Citations1978Robert E. Drake, Kermit A. Gaar +1 more
Filtration characteristics of the exchange vessels in isolated dog lung were studied by calculating the volume conductance (LP,C) with use of different components of the weight-gain curve following changes in capillary pressure.
American Journal of Clinical NutritionPersistent changes in the fatty acid composition of erythrocyte membranes after moderate intake of n−3 polyunsaturated fatty acids: study design implications
120 Citations1991Andrew J. Brown, Ensheng Pang +1 more
Investigators examining variables that are influenced by altered membrane fatty acid composition should be aware of these prolonged effects when designing studies and a parallel design becomes essential.
Clinical ScienceCharacterization of leukotriene B3: comparison of its biological activities with leukotriene B4 and leukotriene B5 in complement receptor enhancement, lysozyme release and chemotaxis of human neutrophils
94 Citations1988TH Lee, Tariq Sethi +6 more
The findings indicate that the pro-inflammatory potential of LTB3 and LTB4 are similar, whereas LTB5 is substantially less potent as an inflammatory mediator, due to the rigidity of the C-17-C-18 double bond in L TB5.
Advances in lipid researchDietary Polyunsaturated Fatty Acids and Eicosanoid Formation in Humans
89 Citations1989Stephan Fischer
Suggestions concerning dietary fatty acids and eicosanoid formation in humans emerging from animal experiments or from in vitro studies should be considered with the utmost care.
Journal of Molecular MedicineA double-blind, randomized, placebo-controlled trial of n-3 fatty acid based lipid infusion in acute, extended guttate psoriasis
80 Citations1993Friedrich Grimminger, Peter Mayser +9 more
Modulation of eicosanoid metabolism by intravenous n-3 fatty acid supplementation appears to exert a rapid beneficial effect on inflammatory skin lesions in acute guttate psoriasis.
Journal of Clinical InvestigationStaphylococcal alpha-toxin elicits hypertension in isolated rabbit lungs. Evidence for thromboxane formation and the role of extracellular calcium.
80 Citations1984Werner Seeger, Matthias M. Bauer +1 more
The conclusion drawn is that staphylococcal alpha-toxin provokes pulmonary vascular hypertension which is apparently mediated by thromboxane A2 formation, which surpasses the biological effect of the simultaneously formed prostaglandin I2.
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid MetabolismEffect of increasing amounts of dietary fish oil on brain and liver fatty composition
76 Citations1990Jean‐Marie Bourre, Michelle Bonneil +6 more
In the liver, nearly all fatty acids (saturated, monounsaturated and polyunsaturated) were affected by high dietary content of fish oil, but liver function was normal: serum vitamin A and E, glutathione peroxidase, alkaline phosphatase, transaminases were not affected.
Journal of Applied PhysiologyIncreased lung vascular permeability after arachidonic acid and hydrostatic challenge
74 Citations1986Werner Seeger, D. Walmrath +2 more
Additional experiments corroborated the severalfold increase in vascular permeability, detectable within 3 min after AA application during acute hydrostatic challenge, and confirmed that Vascular compliance was not altered.
Journal of Cellular Physiology<i>Pseudomonas aeruginosa</i> cytotoxin stimulates prostacyclin production in cultured pulmonary artery endothelial cells: Membrane attack and calcium influx
69 Citations1985Norbert Suttorp, Werner Seeger +3 more
Data are compatible with the notion that Pseudomonas aeruginosa cytotoxin triggers the arachidonic acid pathway in cultured pulmonary artery endothelial cells by calcium influx and suggest that this calcium influx may proceed through toxin created transmembrane lesions.
Scandinavian Journal of ImmunologyRapid Adhesive Responses of Endothelial Cells and of Neutrophils Induced by Leukotriene B4 are Mediated by Leucocytic Adhesion Protein CD18
63 Citations1990Peter Lindström, R. Lerner +2 more
LTB4 induces a transient expression of hyperadhesiveness in HUVEC as well as in neutrophils, and both effects are dependent on expression of CD18.
Cardiovascular ResearchCapillary filtration coefficient: the technique and its application to the small intestine
62 Citations1979P. D. Richardson, D. Neil Granger +1 more
The physiological basis of the capillary filtration coefficient (Kf,c), and its measurement in the small intestine, is discussed, and the volumetric method of determining Kf, c is considered in more detail in an attempt to identify the causes of variability in published values.
Journal of Clinical InvestigationDietary n-3 fatty acid effects on neutrophil lipid composition and mediator production. Influence of duration and dosage.
59 Citations1993Floyd H. Chilton, Manisha J. Patel +3 more
The capacity of n-3 fatty acids provided with a Western diet to be rapidly incorporated into neutrophil lipids is demonstrated, however, dietary n- 3 fatty acids appear not to significantly reduce arachidonate content within neutrophIL phospholipids.
CirculationDietary fish oil reduces leukocyte/endothelium interaction following systemic administration of oxidatively modified low density lipoprotein.
56 Citations1991Hans‐Anton Lehr, Christoph Hübner +5 more
The results of the present study suggest that inhibition of leukocyte/endothelium interaction may be one of the mechanisms by which dietary fish oil exerts its protective effects on experimental and clinical atherogenesis.
European Journal of Clinical InvestigationInfluence of intravenous n‐3 lipid supplementation on fatty acid profiles and lipid mediator generation in a patient with severe ulcerative colitis
53 Citations1993Friedrich Grimminger, D Führer +12 more
The profound changes in fatty acid profiles and lipid mediator generation may be related to the reduction in colitis activity observed during the periods of intravenous n‐3 lipid supplementation.
American Review of Respiratory DiseaseArachidonic Acid Lipoxygenase Pathways and Increased Vascular Permeability in Isolated Rabbit Lungs
53 Citations1987Werner Seeger, Michael D. Menger +4 more
It is shown that during this mode of AA bolus application in cell-free perfused rabbit lungs, microgram amounts of peptidoleukotrienes and LTB4 were released into the recirculating buffer within 5 min and continued to be released even after 2 exchanges of the perfusion fluid.
Acta Anaesthesiologica ScandinavicaActions and interactions of mediator systems and mediators in the pathogenesis of ARDS and multiorgan failure
51 Citations1991H. Neuhof
Journal of Internal MedicineClinical studies on the effects of n‐3 fatty acids on cells and eicosanoids in the cardiovascular system
47 Citations1989Christian Weber
Examination of dietary fatty acids belonging to two different families, the n‐6 and n‐3 fatty acids, might be important nutritional factors contributing to the natural history of atherothrombotic and inflammatory disorders and the mechanisms involved in cell stimulus‐response coupling might reveal and modify processes underlying those disorders.
Intensive Care MedicineDetection of leukotrienes B4, C4 and of their isomers in arterial, mixed venous blood and bronchoalveolar lavage fluid from ARDS patients
44 Citations1989Manila Antonelli, M. Bufi +10 more
The distribution of these arachidonic acid metabolites in mixed venous blood, arterial blood and BAL seems to suggest pulmonary metabolism and/or inactivation of the ARDS.
Biochemical PharmacologyRelease of leukotrienes into the perfusate of calcium-ionophore stimulated rabbit lungs
44 Citations1986Richard Schulz, Werner Seeger
Using a rapid and sensitive extraction and RP-HPLC method isolated lungs are found to release nanomolar amounts of LTs into the perfusate upon repetitive A23187 challenge, suppressed by 5-lipoxygenase inhibition.
American Journal of Clinical NutritionInfusion of fish oil emulsion: effects on platelet aggregation and fatty acid composition in phospholipids of plasma, platelets, and red blood cell membranes in rabbits
42 Citations1987Masaharu Urakaze, Tomohito Hamazaki +5 more
Fish oil emulsion may be beneficial to patients who cannot take n-3 fatty acids orally but need them because of the increased EPA content in phospholipids of plasma, platelets, and red blood cell (RBC) membranes.
Biochemical JournalIncorporation and turnover of eicosapentaenoic and docosahexaenoic acids in human blood platelets <i>in vitro</i>
38 Citations1992Martine Croset, Yves Bayon +1 more
It is concluded that when C20:5 and C22:6, but not C18:2, are acylated in 1,2-diacyl-GPC, they participate in thrombin-dependent phospholipid remodelling, and might compete with the turnover and release of arachidonic acid from plateletospholipids and the subsequent activation of the cells.
DermatologicaLong-Term Administration of Highly Purified Eicosapentaenoic Acid Provides Improvement of Psoriasis
31 Citations2009Tadanobu Kojima, T Terano +4 more
Although its effects are modest, it is nontoxic and its favorable effect appears to continue for the duration of its usage, indicating that EPA could be beneficial for the long-term treatment of psoriasis.
Journal of Applied PhysiologyRole of albumin in prevention of edema in perfused rabbit lungs
30 Citations1981Robert S. Chang, Karen H. Wright +1 more
Albumin concentration gradients across the capillary wall appear to increase with elevations in capillary pressure, and edema formation in in situ rabbit lungs was insignificant during a 60-min perfusion interval.
ProstaglandinsPulmonary microcirculatory responses to leukotrienes B4, C4 and D4 in sheep
27 Citations1985Thomas C. Noonan, D. F. Kern +1 more
LTB4 induces a marked neutropenia, pulmonary hypertension, and may transiently increase lung vascular permeability, and both LTC4 and LTD4 cause a similar degree of pulmonary hypertension in awake sheep, but had different lymph flow responses which may be due to pulmonary vasoconstriction at different sites.
Journal of Applied PhysiologyAlterations of filtration coefficients in pulmonary edema of different pathogenesis
24 Citations1992T. Koch, H.P. Duncker +3 more
Capillary filtration coefficients were significantly higher in the proteinase edema, indicating an irreversibly damaged barrier function, and exemplify different pathophysiological characteristics due to the pathogenesis of interstitial edema formation.
Infusionstherapie und Transfusionsmedizin / Infusion Therapy and Transfusion MedicineModulation of Pulmonary Vascular Resistance and Edema Formation by Short-Term Infusion of a 10% Fish Oil Emulsion
21 Citations2009T. Koch, H.P. Duncker +5 more
The data demonstrate that omega-3 fatty acids seem to be incorporated into the phospholipid pool of the pulmonary tissue, even after short-term infusion, resulting in an attenuated pressure reaction and edema formation due to an altered spectrum of metabolites in the case of inflammatory stimulation.
ShockEFFECTS OF STROMA-FREE HEMOGLOBIN SOLUTIONS ON PULMONARY VASCULAR RESISTANCE AND MEDIATOR RELEASE IN THE ISOLATED PERFUSED RABBIT LUNG
12 Citations1994Thea Koch, HANS PHILIPP DUNCKER +4 more
The results point towards the crucial role of PAF in mediation of vasoconstrictor side effects due to SFH.