Carcinoembryonic Antigen and Prognosis in Patients with Colon Cancer
Annals of SurgeryPublished 1 January 1975Open access
Paul Lo Gerfo, Frederic P. Herter
Citations67
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
One-hundred and fifty patients with non-metastatic colo-rectal cancer were followed for a period of 24 to 36 months postoperatively to study the relationship between preoperative CEA values and the extent of the disease and the patient's prognosis.
Abstract
One-hundred and fifty patients with non-metastatic colo-rectal cancer were followed for a period of 24 to 36 months postoperatively. Preoperative CEA values have been shown to correlate with the extent of the disease and the patient's prognosis. The prognosis for recurrences is greater in patients with elevated pre-operative CEA values regardless of the stage of their disease. This tendency to have recurrences is 1.8 times higher in individuals with increased pre-operative CEA levels. This same relationship occurs to a greater or lesser extent at each stage of the disease.
Keywords
Medicine
The Journal of Experimental MedicineDEMONSTRATION OF TUMOR-SPECIFIC ANTIGENS IN HUMAN COLONIC CARCINOMATA BY IMMUNOLOGICAL TOLERANCE AND ABSORPTION TECHNIQUES
2,323 Citations1965Phil Gold, Samuel O. Freedman
It was shown that the tumor-specific antibodies were not directed against bacterial contaminants or against the unusually high concentrations of fibrin found in many neoplastic tissues.
The Journal of Experimental MedicineSPECIFIC CARCINOEMBRYONIC ANTIGENS OF THE HUMAN DIGESTIVE SYSTEM
1,876 Citations1965Phil Gold, Samuel O. Freedman
It was concluded that the carcinoembryonic antigens represent cellular constituents which are repressed during the course of differentiation of the normal digestive system epithelium and reappear in the corresponding malignant cells by a process of derepressive-dedifferentiation.
Proceedings of the National Academy of SciencesTHE RADIOIMMUNOASSAY OF CIRCULATING CARCINOEMBRYONIC ANTIGEN OF THE HUMAN DIGESTIVE SYSTEM
703 Citations1969David M. Thomson, John Krupey +2 more
The test detects a concentration of 2.5 ng of carcinoembryonic antigen per ml of serum and has provided the first demonstration of a circulating tumor-specific antigen in the sera of cancer patients.
New England Journal of MedicineDemonstration of an Antigen Common to Several Varieties of Neoplasia
457 Citations1971Paul Lo Gerfo, John Krupey +1 more
Serum specimens from 11 of 299 patients hospitalized for various illnesses other than neoplastic disease had elevated levels of antigen, and two patients were found to have previously undetected entodermally derived adenocarcinoma.
BMJRole of Plasma Carcinoembryonic Antigen in Diagnosis of Gastrointestinal, Mammary, and Bronchial Carcinoma
315 Citations1972D. J. R. Laurence, U. Stevens +7 more
Raised plasma levels of carcinoembryonic antigen (C.E.A.A.) occur with many but not all malignant tumours, particularly those of the gastrointestinal tract, breast, and bronchus, but it cannot serve yet as a routine screening test for cancer.
JAMACarcinoembryonic Antigen in Patients With Different Cancers
290 Citations1972Gustavo Reynoso
The plasma CEA levels measured in 346 patients using a new procedure which detects an ion-sensitive antigenic site in the carcinoembryonic molecule appear to be useful in the follow-up of patients with cancer and may eventually be of diagnostic value in the asymptomatic patient.
International Journal of CancerCarcinoembryonic antigen (CEA) in gastrointestinal and extragastrointestinal tumors and its relationship to tumor‐cell differentiation
181 Citations1972Helmut Denk, G Tappeiner +2 more
The localization of CEA on the surface (probably glycocalyx) of the cell, together with its dependence upon a certain degree of tumor cell differentiation, suggest that CEA is a secretion product rather than a constituent of the tumor cell membrane.
New England Journal of MedicineImmunologic Diagnosis and Prognosis of Human Digestive-Tract Cancer: Carcinoembryonic Antigens
175 Citations1972Norman Zamcheck, Terrence Moore +2 more
A large number of tumors form antigens thought to be "specific" — i.e., not present in nonmalignant tissues or present in lesser or inconsequential amounts, but detected in minute amounts by immunochemical methods.
Annals of SurgeryCarcinoembryonic Antigen (CEA) in Patients With Carcinoma of the Digestive Tract
121 Citations1972DOUGLAS HOLYOKE, Gustavo Reynoso +1 more
NatureDemonstration of Carcinoembryonic Antigen in Normal Human Plasma
82 Citations1972T. Ming Chu, Gustavo Reynoso +1 more
The results of the studies on the demonstration of CEA in plasma of normal healthy individuals by radioimmunoassay and column chromatography are reported.
The American Journal of SurgeryTumor-associated antigen in patients with carcinoma of the colon
77 Citations1972Paul Lo Gerfo, F.Lo Gerfo +3 more
The nature and significance of CEA as defined by Gold and Freedman are attempted, in the laboratory, using both their reagents and methods and a radioimmunoassay procedure developed by Thomson et al.
PubMedCarcinoembryonic antigen(s) in liver disease. II. Isolation from human cirrhotic liver and serum and from normal liver.
70 Citations1972Herbert Z. Kupchik, Norman Zamcheck
International Journal of CancerAbsence of circulating antibodies to carcinoembryonic antigen in patients with gastrointestinal malignancies
67 Citations1972Paul Lo Gerfo, Frederic P. Herter +1 more
The zirconyl phosphate gel assay was used to assay sera of 265 patients for humoral activity against carcinoembryonic antigen (CEA) and antibodies directed against CEA could not be detected with either technique.
International Journal of CancerFurther investigations of circulating antibodies in colon cancer patients: On the autoantigenicity of the carcinoembryonic antigen
64 Citations1971E. Collatz, S. von Kleist +1 more
Sera from 190 patients investigated for the presence of circulating antibodies directed against the carcinoembryonic antigen revealed no evidence for the autoantigenicity of this particular antigen, and titers demonstrated in patients' sera were due to antibodies directedagainst normal tissue proteins.
CancerResponse of lymphocytes from patients with gastrointestinal cancer to the carcinoembryonic antigen of the human digestive system
64 Citations1971M. Christine Lejtenyi, Samuel O. Freedman +1 more
No significant response was obtained with lymphocytes from patients with gastrointestinal cancer, pregnant women, or normal individuals with the test system employed, and no evidence for a cell‐mediated immune reaction to the CEA was observed.
New England Journal of MedicineTumor-Associated (CEA-Reacting) Antigen in Patients with Inflammatory Bowel Disease
59 Citations1972Allyn H. Rule, Eugene Straus +2 more
A large number of children with ulcerative colitis are diagnosed with atypical central giant cell granuloma, which is a type of bowel cancer that has a high mortality rate and high incidence of cancer.
Annals of SurgeryTumor Associated Antigen with Pulmonary Neoplasms
40 Citations1972Paul Lo Gerfo, Frederic P. Herter +2 more
European Journal of Cancer (1965)The specificity of carcino-foetal antigens of the human digestive-tract tumours
16 Citations1972Florian Martin, Miguel Martín +2 more
The carcino-embryonic antigen seems not to be cancer specific, although definite quantitative difference may be demonstrated between cancerous and non-cancerous intestine.
Surgical Clinics of North AmericaImmunologic Tests for the Detection of Gastrointestinal Cancers
10 Citations1972Paul Lo Gerfo, Frederic P. Herter +2 more
The four tests described hold promise of clinical usefulness in the near future for the detection and diagnosis of gastrointestinal tumors.
Journal of Surgical ResearchStudies on tumor-associated antigen: TAA
7 Citations1973Paul Lo Gerfo, Frederic P. Herter +2 more
Two antigens with common antigenic determinants that are separable by ion-exchange chromatography and electrophoresis are demonstrated and it is suggested that this antigen is identical to carcinoembryonic antigen (CEA).