Age-dependent deficits in spatial memory are related to impaired hippocampal kindling.
Behavioral NeurosciencePublished 1 January 1984
Leyla de Toledo‐Morrell, Frank Morrell, Shirley Fleming
Citations112
SJR quartileQ2
SJR score0.87
SNIP0.61
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TL;DR
The results indicated that spatial memory was poorer and hippocampal kindling slower in aged rats than in young ones, and there was a striking positive relation between performance in the eight-arm spatial maze and speed of kindling.
Abstract
Fischer 344 rats, 3 and 26 months of age, were first tested in an eight-arm spatial maze to assess memory function behaviorally. The same animals were then subjected to hippocampal kindling to examine alterations in neuronal plasticity as a function of aging. The results indicated that spatial memory was poorer and hippocampal kindling slower in aged rats than in young ones. Furthermore, there was a striking positive relation between performance in the eight-arm spatial maze and speed of kindling. This finding suggests that age-related deficits in spatial memory and hippocampal kindling reflect decreased efficacy of synaptic transmission in a common neuroanatomical substrate.
Keywords
Neuroscience
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