Treatment of Breast Cancer with Medroxyprogesterone Acetate
Annals of Internal MedicinePublished 1 February 1968
Franco M. Muggia, PETER A. CASSILETH, MANUEL OCHOA, FREDERICK A. FLATOW, ALFRED GELLHORN, GEORGE A. HYMAN
Citations78
SJR quartileQ1
SJR score3.38
SNIP3.27
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TL;DR
The prolonged administration of large doses of medroxyprogesterone acetate (MPA) in the treatment of patients with disseminated breast cancer was studied and 3 of the 7 patients continued in remission at writing, 2 had succumbed to the disease, and 2 were receiving other agents.
Abstract
Thirty-four postmenopausal women and two men disseminated breast cancer were treated with medroxyprogesterone acetate, a synthetic steroid with potent and specific progestational activity. Seven women demonstrated objective tumor regression. The mean duration of the response was 12 months. Tumor regression occurred in an additional five patients when the medroxyprogesterone acetate was combined with estrogens. A long "free interval" (from initial therapy to the appearance of distant metastases) and prior response to other hormones appeared to correlate with responsiveness to the progestogen. No serious drug toxicity was encountered.
Keywords
Biochemistry, Genetics and Molecular Biology
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