Effects of physical activity on insulin action and glucose tolerance in obesity
Medicine & Science in Sports & ExercisePublished 1 November 1999
DAVID E. KELLEY, Bret H. Goodpaster
Citations177
SJR quartileQ1
SJR score1.44
SNIP1.48
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TL;DR
A review of currently published clinical trial data supports the conclusion that physical activity can reduce insulin resistance and improve glucose intolerance in obesity.
Abstract
A review of currently published clinical trial data supports the conclusion that physical activity can reduce insulin resistance and improve glucose intolerance in obesity.
Keywords
Medicine
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1,634 Citations1991Susan P. Helmrich, David R. Ragland +2 more
The protective effect of physical activity was strongest in persons at highest risk for NIDDM, defined as those with a high body-mass index, a history of hypertension, or a parental history of diabetes.
The LancetPhysical activity and incidence of non-insulin-dependent diabetes mellitus in women
1,164 Citations1991JoAnn E. Manson, Meir J. Stampfer +7 more
The results indicate that physical activity may be a promising approach to the primary prevention of NIDDM, and risk reduction with exercise was evident among both obese and nonobese women.
DiabetesSkeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action
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New England Journal of MedicineIncreased Glucose Transport–Phosphorylation and Muscle Glycogen Synthesis after Exercise Training in Insulin-Resistant Subjects
692 Citations1996Gianluca Perseghin, Thomas B. Price +6 more
Exercise increases insulin sensitivity in both normal subjects and the insulin-resistant offspring of diabetic parents because of a twofold increase in insulin-stimulated glycogen synthesis in muscle, due to an increase in Diabetes mellitus-related glucose transport-phosphorylation.
JAMAEffects of Lifestyle Activity vs Structured AerobicExercise in Obese Women
622 Citations1999Ross E. Andersen, Thomas A. Wadden +4 more
A program of diet plus lifestyle activity may offer similar health benefits and be a suitable alternative to diet plus structured aerobic activity for obese women.
JAMAIntensity and Amount of Physical Activity in Relation to Insulin Sensitivity
598 Citations1998Elizabeth J. Mayer-Davis
Increased participation in nonvigorous as well as overall and vigorous physical activity was associated with significantly higher insulin sensitivity, and these findings lend further support to current public health recommendations for increased moderate-intensity physical activity on most days.
JAMAA prospective study of exercise and incidence of diabetes among US male physicians
597 Citations1992JoAnn E. Manson
JAMAA Prospective Study of Exercise and Incidence of Diabetes Among US Male Physicians
564 Citations1992JoAnn E. Manson
Exercise appears to reduce the development of non-insulin-dependent diabetes mellitus even after adjusting for body-mass index, and increased physical activity may be a promising approach to the primary prevention of NIDDM.
Journal of Applied PhysiologyMuscle triglyceride utilization during exercise: effect of training
525 Citations1986B. F. Hurley, P. M. Nemeth +4 more
The results suggest that the greater utilization of FFA in the trained state is fueled by increased lipolysis of muscle triglyceride, suggesting reduced availability of plasma FFA.
Medicine & Science in Sports & ExerciseACSM Position Stand: The Female Athlete Triad
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The Female Athlete Triad is a syndrome occurring in physically active girls and women whose interrelated components are disordered eating, amenorrhea, and osteoporosis.
Journal of Clinical InvestigationImpaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitus.
483 Citations1994David E. Kelley, J. A. Simoneau
During postabsorptive conditions, there is reduced utilization of FFA by muscle, while during postprandial conditions there is impaired suppression of F FA uptake across the leg in NIDDM.
Sports MedicineRole of Exercise Training in the Prevention and Treatment of Insulin Resistance and Non-Insulin-Dependent Diabetes Mellitus
370 Citations1997John L. Ivy
Exercise training has been found to help alleviate the problem of insulin resistance, and substantially improve the control of insulin over blood glucose, and to help prevent muscle atrophy and stimulate muscle development.
Diabetes CareDaily Walking Combined With Diet Therapy Is a Useful Means for Obese NIDDM Patients Not Only to Reduce Body Weight But Also to Improve Insulin Sensitivity
332 Citations1995Kunio Yamanouchi, Takashi Shinozaki +10 more
Walking, which can be safely performed and easily incorporated into daily life, can be recommended as an adjunct therapy to diet treatment in obese NIDDM patients, not only for BW reduction, but also for improvement of insulin sensitivity.
JAMAEffects of Weight Loss vs Aerobic Exercise Training on Risk Factors for Coronary Disease in Healthy, Obese, Middle-aged and Older Men
295 Citations1995Leslie I. Katzel
The results suggest that weight loss is the preferred treatment to improve coronary artery disease risk factors in overweight, middle-aged and older men.
Diabetes CareResistance Training Improves Insulin Sensitivity in NIDDM Subjects Without Altering Maximal Oxygen Uptake
278 Citations1998Tomofusa Ishii, Tetsuya Yamakita +3 more
Moderate-intensity, high-volume resistance training improves insulin sensitivity in nonobese NIDDM without altering VO2max and body composition.
DiabetologiaStudies on the mechanism of improved glucose control during regular exercise in Type 2 (non-insulin-dependent) diabetes
261 Citations1984Steven H. Schneider, Louis F. Amorosa +2 more
It is suggested that an exercise programme can produce a significant decrease in glycosylated haemoglobin levels in Type 2 diabetic males probably due, in great measure, to the cumulative effect of transient improvements in glucose tolerance which follow each individual period of exercise.
Diabetes CareImprovement in Glucose Tolerance After 1 Wk of Exercise in Patients With Mild NIDDM
204 Citations1988Marc A. Rogers, Chikashi Yamamoto +4 more
Evidence is provided that regularly performed, vigorous exercise can be effective in decreasing insulin resistance and improving glucose tolerance within 7 days in some patients with mild NIDDM.
Journal of Applied PhysiologyDistinct effects of aerobic exercise training and weight loss on glucose homeostasis in obese sedentary men
188 Citations1996Donald R. Dengel, Richard E. Pratley +3 more
It is suggested that AEX and WL improve glucose metabolism through different mechanisms and that the combined intervention of AEX+WL is necessary to improve both glucose tolerance and insulin sensitivity in older men.
Journal of Applied PhysiologyTime course for exercise-induced alterations in insulin action and glucose tolerance in middle-aged people
186 Citations1995D. S. King, P. J. Baldus +4 more
The purposes of this study were to investigate glucose tolerance and insulin action immediately after exercise and to determine how long the improved glucose homeostatic mechanisms observed 12-16 h after exercise persist.
DiabetologiaNo excess 12-year mortality in men with impaired glucose tolerance who participated in the Malm� Preventive Trial with diet and exercise
182 Citations1998Karl‐Fredrik Eriksson, F. Lindg�rde
The findings suggest that a long-term intervention programme, with an emphasis on lifestyle changes, including dietary counselling and physical exercise, will reduce mortality in subjects with IGT who are at an increased risk of both developing NIDDM and of premature death due to IHD and other causes.
Diabetes CareEffect of Exercise Intensity on Glucose and Insulin Metabolism in Obese Individuals and Obese NIDDM Patients
180 Citations1996Jie Kang, Robert J. Robertson +6 more
It is concluded that the exercise-induced improvement in insulin sensitivity is influenced by exercise intensity in obese individuals and may be related to greater muscle glycogen utilization during exercise.
Hormone and Metabolic ResearchAerobic Endurance Exercise or Circuit-Type Resistance Training for Individuals with Impaired Glucose Tolerance?
161 Citations1998Johan G. Eriksson, J. A. Tuominen +6 more
By improving insulin sensitivity, circuit-type resistance training may postpone the manifestations of NIDDM in these high-risk individuals and should therefore be included in an exercise program for IGT subjects.
International Journal of BiometeorologyShinrin-yoku (forest-air bathing and walking) effectively decreases blood glucose levels in diabetic patients
156 Citations1998Yoshinori Ohtsuka, Noriyuki Yabunaka +1 more
It is presumed that, in addition to the increased calorie consumption and improved insulin sensitivity, walking in a forest environment has other beneficial effects in decreasing blood glucose levels.
Journal of Applied PhysiologyEffects of exercise intensity on insulin sensitivity in women with non-insulin-dependent diabetes mellitus
128 Citations1995Barry Braun, Michael Zimmermann +1 more
Under these conditions LO is as effective as HI in enhancing insulin sensitivity in people with NIDDM, and plasma insulin response was lower for HI and LO compared with NX.
Sports MedicineExercise in the Management of Non???Insulin-Dependent Diabetes Mellitus
127 Citations1998Harriet Wallberg‐Henriksson, Jorge Rincón +1 more
It is important to diagnose proliferative retinopathy, microalbuminuria, peripheral and/or autonomic neuropathy in patients with NIDDM before they participate in an exercise programme, and to establish a testing programme which includes VO2max determinations for individuals who are at risk of developing NID DM.
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118 Citations1994M. A. Smutok, Christine Reece +7 more
MetabolismImprovements in blood pressure, glucose metabolism, and lipoprotein lipids after aerobic exercise plus weight loss in obese, hypertensive middle-aged men
109 Citations1998Donald R. Dengel, James M. Hagberg +3 more
A 6-month AEX+WL intervention substantially lowers BP and improves glucose and lipid metabolism in obese, sedentary, hypertensive men, suggesting that hypertension and the metabolic risk factors for cardiovascular disease associated with it can be ameliorated by AEX-WL.
Annals of MedicineEarly Lifestyle Intervention in Patients with Non-insulin-dependent Diabetes Mellitus and Impaire Glucose Tolerance
90 Citations1996Matti Uusitupa
Pilot results show that glucose tolerance can be improved by lifestyle changes, and one-year dietary and exercise intervention on newly diagnosed NIDDM patients in Kuopio, Finland resulted in a better metabolic control and a moderate reduction in cardiovascular risk factors as compared to the conventional treatment group.
Journal of the American Geriatrics SocietyModerate‐Intensity Aerobic Training Improves Glucose Tolerance in Aging Independent of Abdominal Adiposity
88 Citations1998Loretta DiPietro, Teresa E. Seeman +3 more
The hypothesis that training‐related improvements in glucose and insulin responses to an oral glucose tolerance test (OGTT) are independent of changes in abdominal adiposity is tested.
Journal of Internal MedicineEffects on glucose tolerance, insulin secretion, insulin‐like growth factor 1 and its binding protein, IGFBP‐1, in a randomized controlled diet and exercise study in healthy, middle‐aged men
83 Citations1995Mai-Lis Hellénius, Kerstin Brismar +2 more
To study the effects of advice on diet, exercise and their combination on oral glucose tolerance (OGTT), insulin secretion, insulin‐like growth factor‐1 (IGF‐1) and its binding protein, IGFBP‐1.
Medicine & Science in Sports & ExerciseSubstrate utilization and glucose turnover during exercise of varying intensities in individuals with NIDDM
71 Citations1999Jie Kang, DAVID E. KELLEY +5 more
Exercise results in a greater increase in plasma glucose utilization in patients with NIDDM compared with that in normal individuals, and this increase mediates the decline in Plasma glucose concentrations in patientsWith NID DM, despite a greater glucose utilization, carbohydrate and fat oxidation are similar in the two groups and their relations to exercise intensity are not altered by NIDDL.
HypertensionImprovement of Insulin Sensitivity by Short-term Exercise Training in Hypertensive African American Women
68 Citations1997Michael D. Brown, Geoffrey E. Moore +3 more
It is indicated that short-term exercise can improve insulin resistance in hypertensive, obese, sedentary African American women and confirms previous reports that a portion of the exercise-induced improvements in glucose and insulin metabolism may be the result of recent exercise.
DiabetesGlucose production, utilization, and cycling in response to moderate exercise in obese subjects with type 2 diabetes and mild hyperglycemia.
67 Citations1998Adria Giacca, Yolanda Groenewoud +3 more
During moderate-intensity exercise in obese diabetic subjects with mild hyperglycemia, insulin secretory responses were normally regulated and glucose homeostasis was different from that in nondiabetic subjects because glucose levels decreased during exercise.
Diabetes CarePhysical Activity and NIDDM in African-Americans: The Pitt County Study
60 Citations1998Sherman A. James, Lama Said Jamjoum +4 more
Moderate physical activity was strongly associated with reduced risk for NIDDM in this sample and public health interventions designed to increase moderate (leisure-time) physical activity in black adults should be strongly encouraged.
American Journal of Clinical NutritionLong-term effects of a high-carbohydrate diet and exercise on insulin action in older subjects with impaired glucose tolerance
52 Citations1995VA Hughes, MA Fiatarone +4 more
The results do not support the recommendation to increase the dietary carbohydrate content for improving postprandial glucose metabolism or insulin action in glucose-intolerant adults unless combined with exercise training, which promotes muscle glycogen storage.
Preventive MedicineThe Protective Effect of Good Physical Fitness When Young on the Risk of Impaired Glucose Tolerance When Old
15 Citations1999Yousuke Takemura, Shogo Kikuchi +3 more
It is concluded that the occurrence of IGT, including diabetes, in men in their 50s can be reduced by maintaining a high level of physical fitness while in their 30s.
European Journal of Applied PhysiologySignificant changes in VLDL-Triacylglycerol and glucose tolerance in obese subjects following ten days of training
10 Citations1998Theodore J. Angelopoulos, Rebecca Lewis +2 more
It is suggested that short-term exercise, without concomitant loss of body mass, induces favorable changes in plasma triacylglycerol, and very lowdensity lipoprotein-triacyl glycerol and glucose tolerance but has no effect on high density lipoproteincholesterol.