Diffusion–collision model for protein folding
BiopolymersPublished 1 June 1979
Martin Karplus, D. L. Weaver
Citations183
SJR quartileQ2
SJR score0.55
SNIP0.57
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TL;DR
Refinements and biological implications of the mechanism are considered; included are detailed discussions of the parameters of the model, the possibilities of rotational diffusion and surface diffusion in one or two dimensions, the nature of the microdomains, and the application of themodel to protein unfolding.
Abstract
Abstract The basic equations for the elementary step in the diffusion–collision–coalescence model of protein folding are derived for the case of two radially diffusing spherical microdomains. Refinements and biological implications of the mechanism are considered; included are detailed discussions of the parameters of the model, the possibilities of rotational diffusion and surface diffusion in one or two dimensions, the nature of the microdomains, and the application of the model to protein unfolding.
Keywords
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