Regulation of the Mammalian Pineal by Non-rod, Non-cone, Ocular Photoreceptors
SciencePublished 16 April 1999
Robert J. Lucas, Melanie S. Freedman, M. Muñoz, José M. García‐Fernández, F. Foster
Citations519
SJR quartileQ1
SJR score10.42
SNIP6.62
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TL;DR
Despite the loss of all known retinal photoreceptors, rd/rd cl mice showed normal suppression of pineal melatonin in response to monochromatic light of wavelength 509 nanometers, indicating that mammals have additional ocular photoreceptorors that they use in the regulation of temporal physiology.
Abstract
In mammals, ocular photoreceptors mediate an acute inhibition of pineal melatonin by light. The effect of rod and cone loss on this response was assessed by combining the rd mutation with a transgenic ablation of cones (cl) to produce mice lacking both photoreceptor classes. Despite the loss of all known retinal photoreceptors, rd/rd cl mice showed normal suppression of pineal melatonin in response to monochromatic light of wavelength 509 nanometers. These data indicate that mammals have additional ocular photoreceptors that they use in the regulation of temporal physiology.
Keywords
Agricultural and Biological SciencesNeuroscience
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