Genotype Score in Addition to Common Risk Factors for Prediction of Type 2 Diabetes
New England Journal of MedicinePublished 19 November 2008Open access
James B. Meigs, Peter Shrader, Lisa Sullivan, Jarred B. McAteer, Caroline S. Fox, Josée Dupuis
Citations757
SJR quartileQ1
SJR score19.08
SNIP13.47
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
A genotype score based on 18 risk alleles predicted new cases of diabetes in the community but provided only a slightly better prediction of risk than knowledge of common risk factors alone.
Abstract
A genotype score based on 18 risk alleles predicted new cases of diabetes in the community but provided only a slightly better prediction of risk than knowledge of common risk factors alone.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
BiometricsComparing the Areas under Two or More Correlated Receiver Operating Characteristic Curves: A Nonparametric Approach
22,316 Citations1988Elizabeth R. DeLong, David M. DeLong +1 more
A nonparametric approach to the analysis of areas under correlated ROC curves is presented, by using the theory on generalized U-statistics to generate an estimated covariance matrix.
BiometricsLongitudinal Data Analysis for Discrete and Continuous Outcomes
7,834 Citations1986Scott L. Zeger, Kung‐Yee Liang
A class of generalized estimating equations (GEEs) for the regression parameters is proposed, extensions of those used in quasi-likelihood methods which have solutions which are consistent and asymptotically Gaussian even when the time dependence is misspecified as the authors often expect.
Diabetes CareGlobal Burden of Diabetes, 1995–2025: Prevalence, numerical estimates, and projections
6,342 Citations1998Hilary King, Ronald E. Aubert +1 more
This report supports earlier predictions of the epidemic nature of diabetes in the world during the first quarter of the 21st century and provides a provisional picture of the characteristics of the diabetes epidemic.
Statistics in MedicineEvaluating the added predictive ability of a new marker: From area under the ROC curve to reclassification and beyond
6,328 Citations2007Michael J. Pencina, Ralph B. D' Agostino +2 more
Two new measures, one based on integrated sensitivity and specificity and the other on reclassification tables, are introduced that offer incremental information over the AUC and are proposed to be considered in addition to the A UC when assessing the performance of newer biomarkers.
ScienceThe Structure of Haplotype Blocks in the Human Genome
5,921 Citations2002Stacey Gabriel, S. F. Schaffner +16 more
It is shown that the human genome can be parsed objectively into haplotype blocks: sizable regions over which there is little evidence for historical recombination and within which only a few common haplotypes are observed.
Annals of Internal MedicineClinical Epidemiology: A Basic Science for Clinical Medicine.
3,508 Citations1991
Clinical Epidemiology is a book dedicated to H.L. Mencken, Kurt Vonnegut, Jr., Douglas Adams, and the Emperor's New Clothes and Physicians and others who wish to recognize key clinical epidemiologic features of the diagnosis and management of patients will benefit from reading.
NatureA genome-wide association study identifies novel risk loci for type 2 diabetes
3,007 Citations2007Robert Sladek, Ghislain Rocheleau +20 more
Four loci containing variants that confer type 2 diabetes risk are identified and constitute proof of principle for the genome-wide approach to the elucidation of complex genetic traits.
New England Journal of MedicineDiet, Lifestyle, and the Risk of Type 2 Diabetes Mellitus in Women
2,907 Citations2001Frank B. Hu, JoAnn E. Manson +5 more
ScienceGenome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels
2,888 Citations2007Richa Saxena, Benjamin F. Voight +65 more
The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases.
ScienceA Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants
2,774 Citations2007Laura J. Scott, Karen L. Mohlke +39 more
American Journal of NephrologyDialysis Dose and Intradialytic Hypotension: Results from the HEMO Study
2,699 Citations2013Finnian R. Mc Causland, Steven M. Brunelli +1 more
Nature GeneticsVariant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
2,248 Citations2006Struan F.A. Grant, Guðmar Þorleifsson +27 more
A microsatellite within intron 3 of the transcription factor 7–like 2 gene (TCF7L2; formerly TCF4) was associated with type 2 diabetes mellitus and is thought to act through regulation of proglucagon gene expression in enteroendocrine cells via the Wnt signaling pathway.
ScienceReplication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes
2,204 Citations2007Eleftheria Zeggini, Michael N. Weedon +24 more
These findings provide insight into the genetic architecture of type 2 diabetes, emphasizing the contribution of multiple variants of modest effect and underscore the importance of pathways influencing pancreatic beta cell development and function in the etiology of type 1 diabetes.
CirculationUse and Misuse of the Receiver Operating Characteristic Curve in Risk Prediction
2,094 Citations2007Nancy R. Cook
The c statistic, or area under the receiver operating characteristic (ROC) curve, achieved popularity in diagnostic testing, in which the test characteristics of sensitivity and specificity are relevant to discriminating diseased versus nondiseased patients, may not be optimal in assessing models that predict future risk or stratify individuals into risk categories.
Nature GeneticsMeta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
1,861 Citations2008Eleftheria Zeggini, Laura J. Scott +96 more
The results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D, and detect at least six previously unknown loci with robust evidence for association.
American Journal of EpidemiologyAN INVESTIGATION OF CORONARY HEART DISEASE IN FAMILIES
1,656 Citations1979William B. Kannel, Manning Feinleib +3 more
There is little evidence that coronary heart disease (CHD) experience and CHD risk factors differ in parents of those who volunteered for this study and the parents ofThose who did not volunteer.
BMJPharmacological and lifestyle interventions to prevent or delay type 2 diabetes in people with impaired glucose tolerance: systematic review and meta-analysis
1,179 Citations2007Clare Gillies, Keith R. Abrams +5 more
Lifestyle and pharmacological interventions reduce the rate of progression to type 2 diabetes in people with impaired glucose tolerance and seem to be at least as effective as drug treatment.
BiometricsBest Subsets Logistic Regression
1,158 Citations1989David W. Hosmer, Borko Jovanovic +1 more
The purpose of this note is to illustrate that for one of the more frequently used nonnormal regression models, logistic regression, one may perform the Lawless-Singhal analysis with any best subsets linear regression program that allows for case weights.
PubMedPrediction of incident diabetes mellitus in middle-aged adults: the Framingham Offspring Study.
979 Citations2007Peter W.F. Wilson, James B Meigs +4 more
Parental diabetes, obesity, and metabolic syndrome traits effectively predict type 2 diabetes mellitus risk in a middle-aged white population sample and were used to develop a simple T2DM prediction algorithm to estimate risk of new T2 DM during a 7-year follow-up interval.
New England Journal of Medicine<i>TCF7L2</i> Polymorphisms and Progression to Diabetes in the Diabetes Prevention Program
837 Citations2006José C. Florez, Kathleen A. Jablonski +7 more
The risk-conferring genotypes in TCF7L2 are associated with impaired beta-cell function but not with insulin resistance, and seem to be associated with an increased risk of diabetes among persons with impaired glucose tolerance.
Statistics in MedicineRelation of pooled logistic regression to time dependent cox regression analysis: The framingham heart study
792 Citations1990Ralph B. D’Agostino, Mei‐Ling Ting Lee +4 more
Numerical examples covering a variety of sample sizes and proportions of events display the closeness of this relationship in situations typical of the Framingham Study.
Genome ResearchPrediction of individual genetic risk to disease from genome-wide association studies
770 Citations2007Naomi R. Wray, Michael E. Goddard +1 more
The number and effect size of risk loci that underlie complex disease constrained by the disease parameters of prevalence and heritability are investigated and an approach to assess the genetic risk of a disease in healthy individuals is proposed, based on dense genome-wide SNP panels.
DiabetesParental transmission of type 2 diabetes: the Framingham Offspring Study.
665 Citations2000James B. Meigs, L. Adrienne Cupples +1 more
Risk ratios for offspring type 2 diabetes are consistent with a simple additive risk model, where risk when both parents are affected equals the sum of risk when either parent is affected.
Annals of Internal MedicineIdentification of Persons at High Risk for Type 2 Diabetes Mellitus: Do We Need the Oral Glucose Tolerance Test?
512 Citations2002Michael P. Stern, Ken Williams +1 more
A need has arisen to identify persons at high risk for diabetes so that physicians can offer them preventive interventions and develop multivariable models that use readily available clinical variables to predict the development of diabetes.
New England Journal of MedicineThe Limitations of Risk Factors as Prognostic Tools
468 Citations2006James H. Ware
Research has shown that a risk factor must have a much stronger association with the disease outcome than the authors ordinarily see in etiologic research if it is to provide a basis for early diagnosis or prediction in individual patients.
Diabetes CareIdentifying Individuals at High Risk for Diabetes
443 Citations2005María Inês Schmidt, Bruce Bartholow Duncan +7 more
Rules derived from clinical information, alone or combined with simple laboratory measures, can characterize degrees of diabetes risk in middle-aged adults, permitting preventive actions of appropriate intensity.
New England Journal of MedicineLetting the Genome out of the Bottle — Will We Get Our Wish?
357 Citations2008David J. Hunter, Muin J. Khoury +1 more
The technology behind the personal genomics testing services that are being offered directly to consumers and the limitations in the information they provide are discussed.
DiabetesAssessing the Combined Impact of 18 Common Genetic Variants of Modest Effect Sizes on Type 2 Diabetes Risk
296 Citations2008Hana Lango Allen, Colin N.A. Palmer +6 more
Currently, common risk variants for type 2 diabetes do not provide strong predictive value at a population level, however, the joint effect of risk variants identified subgroups of the population at substantially different risk of disease.
PLoS MedicineCombining Information from Common Type 2 Diabetes Risk Polymorphisms Improves Disease Prediction
265 Citations2006Michael N. Weedon, Mark I. McCarthy +9 more
Combining information from several known common risk polymorphisms allows the identification of population subgroups with markedly differing risks of developing type 2 diabetes compared to those obtained using single polymorphisms.
Statistics in MedicineComparison of baseline and repeated measure covariate techniques in the Framingham heart study
255 Citations1988L. Adrienne Cupples, Ralph B. D’Agostino +2 more
The technique is a generalized person-years approach in that it treats each observation interval as a mini-follow-up study in which the current risk factor measurements are employed to predict an event in the interval.
BiometricsA Comparison of Tests for Hardy-Weinberg Equilibrium
244 Citations1980Ted H. Emigh
The various tests for the goodness of fit of a population to Hardy-Weinberg equilibrium are compared with respect to their power and the accuracy of their distributional approximations.
Annals of Internal MedicineMetabolic Risk Factors Worsen Continuously across the Spectrum of Nondiabetic Glucose Tolerance: The Framingham Offspring Study
195 Citations1998James B. Meigs, David M. Nathan +3 more
The distribution of metabolic risk factors for type 2 diabetes or cardiovascular disease across the full spectrum of glucose tolerance in an unselected, well-characterized, community-based population sample suggests that elevated metabolic risk may not be confined to the discrete categories of impaired glucose tolerance and type 1 diabetes.
Annals of Internal MedicineAccuracy of Offspring Reports of Parental Cardiovascular Disease History: The Framingham Offspring Study
186 Citations2004Joanne M. Murabito, Byung‐Ho Nam +4 more
A better understanding of the magnitude of misreporting of family history information and the factors related to misreporting is needed to enhance physicians' ability to reliably use a patient's reported family history and identify those at increased risk for disease.
DiabetesImpact of Common Type 2 Diabetes Risk Polymorphisms in the DESIR Prospective Study
158 Citations2007Martine Vaxillaire, J Veslot +11 more
The data confirm several at-risk polymorphisms for type 2 diabetes in a general population and demonstrate that prospective studies are valuable designs to complement classical genetic approaches.
DiabetesAssociation Analysis in African Americans of European-Derived Type 2 Diabetes Single Nucleotide Polymorphisms From Whole-Genome Association Studies
152 Citations2008Joshua P. Lewis, Nicholette D. Palmer +6 more
Results suggest that types 2 diabetes genes identified in whole-genome association studies in a large African American case-control population do not significantly contribute to interindividual susceptibility to type 2 diabetes in African Americans.
PLoS MedicineGenetic Prediction of Future Type 2 Diabetes
142 Citations2005Valeriya Lyssenko, Peter Almgren +7 more
It is demonstrated in a large prospective study that variants in the PPARG and CAPN10 genes predict future T2D and genetic testing might become a future approach to identify individuals at risk of developing T1D.
Diabetic MedicineRisk of diabetes in siblings of index cases with Type 2 diabetes: implications for genetic studies
110 Citations2002Catherine F. Weijnen, Stephen S. Rich +3 more
The goal was to estimate the sibling recurrence‐risk ratio for Type 2 diabetes in families with diabetes occurring in middle age and to identify determinants of the recurrence risk.
The Journal of Clinical Endocrinology & MetabolismThe Insulin Gene Variable Number Tandem Repeat and Risk of Type 2 Diabetes in a Population-Based Sample of Families and Unrelated Men and Women
48 Citations2005James B. Meigs, Josée Dupuis +4 more
The hypothesis that the insulin gene variable number tandem repeat (INS VNTR) minisatellite is a genetic risk factor for type 2 diabetes is supported, with the TT genotype accounting for about 6.6% of cases in the FHS population.
PLoS MedicineDoes Genetic Testing Really Improve the Prediction of Future Type 2 Diabetes?
34 Citations2006A. Cecile J.W. Janssens, Marta Gwinn +2 more
Archives of Internal MedicineValidation of a Simple Clinical Diabetes Prediction Model in a Middle-aged, White, German Population
8 Citations2007Jiang Li, Stefan R. Bornstein +2 more