The calcium channel
Trends in NeurosciencesPublished 1 January 1983
Susumu Hagiwara, L Byerly
Citations104
SJR quartileQ1
SJR score4.73
SNIP3.68
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TL;DR
The application of intracellular perfusion and patch clamp techniques to the somal membranes of excitable cells has recently allowed rapid advancement in understanding of the biophysical properties of the Ca 2+ channel, and detection of outward current through Ca + channels and instantaneous current measurements have provided information on the selectivity and current-voltage properties of open Ca 2- channels.
Abstract
The application of intracellular perfusion and patch clamp techniques to the somal membranes of excitable cells has recently allowed rapid advancement in our understanding of the biophysical properties of the Ca2+ channel. The activation of the Ca2+ channel involves a series of slow and fast steps, while Ca2+ current inactivation can result from a number of distinct processes. Recent detection of outward current through Ca+ channels and instantaneous current measurements have provided information on the selectivity and current-voltage properties of open Ca2+ channels. The ability of Ca2+ channels to carry current appears to require as yet unidentified intracellular factors.
Keywords
NeuroscienceBiochemistry, Genetics and Molecular Biology
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