Helicobacter pylori cagA gene and expression of cytokine messenger RNA in gastric mucosa
GastroenterologyPublished 1 June 1996Open access
Yoshio Yamaoka, Masaki Kita, Tadashi Kodama, N. Sawai, Jirô Imanishi
Citations335
SJR quartileQ1
SJR score7.20
SNIP5.04
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Investigation of the relationship between cagA gene and cytokine messenger RNA (mRNA) expression in gastric mucosa suggests that IL-8 may play important roles in the pathogenesis of gastroduodenal diseases associated with H. pylori infection.
Abstract
cagA-positive strains induce the expression of IL-8 mRNA, suggesting that IL-8 may play important roles in the pathogenesis of gastroduodenal diseases associated with H. pylori infection.
Keywords
Medicine
Proceedings of the National Academy of SciencesQuantitation of mRNA by the polymerase chain reaction.
1,638 Citations1989A M Wang, Michael Doyle +1 more
This quantitative PCR method provides a rapid and reliable way to quantify the amount of a specific mRNA in a sample of less than 0.1 ng of total RNA.
Scandinavian Journal of GastroenterologyExpression of Cytokine mRNA in Gastric Mucosa with<i>Helicobacter pylori</i>Infection
103 Citations1995Yoshio Yamaoka, Masaki Kita +4 more
These findings suggest that some cytokines, especially IL-7 and IL-8, play some roles in H. pylori-associated gastritis.