Paroxetine does not improve symptoms and impairs cognition in frontotemporal dementia: a double-blind randomized controlled trial
PsychopharmacologyPublished 19 March 2004
S. Rahman, Peter J. Nestor, J. R. Hodges, Barbara J. Sahakian, Julia Deakin
Citations224
SJR quartileQ1
SJR score1.16
SNIP0.97
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TL;DR
It is suggested that a chronic course of paroxetine may selectively impair paired associates learning, reversal learning and delayed pattern recognition, which closely resembles that seen after tryptophan depletion.
Abstract
This study finds no evidence for the efficacy of paroxetine in the treatment of fvFTD. The results suggest that a chronic course of paroxetine may selectively impair paired associates learning, reversal learning and delayed pattern recognition. This pattern of deficits closely resembles that seen after tryptophan depletion. Results are discussed with respect to current theories on serotonergic modulation of orbitofrontal/ventromedial prefrontal cortex.
Keywords
Medicine
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