MEASUREMENT OF THE LATERAL COMPRESSIBILITY OF SEVERAL PHOSPHOLIPID BILAYERS
Biophysical JournalPublished 1 March 1982Open access
L.J. Lis, M. McAlister, Nola Fuller, R.P. Rand, V. Adrian Parsegian
Citations162
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TL;DR
Lateral compressibilities of bilayers in multilayer lattices are given for 10 phospholipid preparation as well as cholesterol-containing bilayers of dipalmitoyl PC or of egg PC, finding that measurements do not correspond in any obvious way to lateral compressibilities in monolayers at the air-water interface.
Abstract
Lateral compressibilities of bilayers in multilayer lattices are given for 10 phospholipid preparation:dilauryl-, dimyristoyl-, dipalmitoyl-, distearoyl-, and dioleoylphosphatidylcholine (PC); egg phosphatidylethanolamine (PE); as well as cholesterol-containing bilayers of dipalmitoyl PC or of egg PC. Bilayer deformability is highly nonlinear and does not permit description in terms of a simple modulus. The presence of cholesterol or C=C bonds (dioleoyl PC) increases deformability, but freezing of acyl chains does not cause dramatic stiffening of the bilayer. Lateral compression of dilauryl PC an dimyristoyl PC causes a transition from "melted" to "frozen" acyl chains above the normal transition temperatures. Our measurements do not correspond in any obvious way to lateral compressibilities in monolayers at the air-water interface.
Keywords
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