Thiourea-Catalyzed Enantioselective Cyanosilylation of Ketones
Journal of the American Chemical SocietyPublished 1 June 2005
Douglas E. Fuerst, Eric N. Jacobsen
Citations322
SJR quartileQ1
SJR score5.55
SNIP2.61
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TL;DR
The new chiral amino thiourea catalyst 3d promotes the highly enantioselective cyanosilylation of a wide variety of ketones, suggesting a cooperative mechanism involving electrophile activation by thiOUrea and nucleophile activation by the amine.
Abstract
The new chiral amino thiourea catalyst 3d promotes the highly enantioselective cyanosilylation of a wide variety of ketones. The hindered tertiary amine substituent plays a crucial role with regard to both stereoinduction and reactivity, suggesting a cooperative mechanism involving electrophile activation by thiourea and nucleophile activation by the amine.
Keywords
Chemistry
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