Primary cutaneous CD30-positive large cell lymphoma: Definition of a new type of cutaneous lymphoma with a favorable prognosis.A European multicenter study of 47 patients
CancerPublished 15 March 1993
Rob C. Beljaards, Peter Kaudewitz, Emilio Berti, Raffaele Gianotti, Christine Neumann, R. Rosso
Citations318
SJR quartileQ1
SJR score2.95
SNIP1.90
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TL;DR
There is no consensus regarding the definition of these primary cutaneous CD30‐positive LCL, but recent studies indicate that these lymphomas, when confined to the skin, have a favorable prognosis.
Abstract
The results of this study indicate that primary cutaneous CD30-positive LCL, regardless of their morphologic classification (anaplastic or nonanaplastic) can be considered as a distinct type of cutaneous T-cell lymphoma. Recognition of this type of cutaneous lymphoma is important because it may prevent patients from unnecessary aggressive treatment.
Keywords
Medicine
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Results obtained indicate that Ki-1 antigen is an inducible lymphoid-associated molecule that identifies a group of hitherto poorly characterized normal and neoplastic large lymphoid cells in Hodgkin's disease and Disorders in which only a minority of cells express Ki- 1 antigen probably represent lesions in whichonly some of the abnormal cells have transformed into an "activation state.
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The American Journal of Surgical PathologyKi-1 Positive Large Cell Lymphoma
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It is concluded that a diagnosis of Ki-1 + large cell lymphoma should be considered in any pleomorphic tumor with the features described in this report.
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330 Citations1968Warren L. Macaulay
A 41-year-old woman has an asymptomatic eruption of three years' duration that shows an alarming infiltrate of anaplastic cells of disputatious origin, suggesting a diagnosis of malignant lymphoma.
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208 Citations1989Peter Kaudewitz, H Stein +5 more
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177 Citations1985Marshall E. Kadin, K Nasu +3 more
A distinctive immunologic phenotype was demonstrated for the characteristic large atypical cells in skin lesions of 9 patients with lymphomatoid papulosis and a possible transition between small, medium, and large cells expressing only T- cell antigens and large transformed RS-like cells expressing both T-cell and HD-associated antigen was shown by immunoelectron microscopy.
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155 Citations1989Rob C. Beljaards, Chris J.L.M. Meijer +6 more
The histologic and immunophenotypical features of 20 primary cutaneous large-cell lymphomas of T-cell origin were investigated and correlated with clinical data to obtain prognostically relevant criteria, and it was concluded that the clinical relevance of histologic subtyping is limited for this group of lymphomas.
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124 Citations1983GS Wood, JS Burke +4 more
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120 Citations1991Robert Penny, Janina A. Longtine +2 more
Ki‐1–positive large cell lymphomas are characterized by clinical, morphologic, and immunophenotypic heterogeneity, with a bimodal distribution and peaks in the third and seventh decades.
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110 Citations1982Kevin J. Flynn, Louis P. Dehner +4 more
Histopathologically, characteristic‐appearing atypical mononuclear and multinucleated “RAH” cells showed erythrophagocytosis as well as ultrastructural, surface marker, and enzyme cytochemical features indicating histiocytic differentiation.
HistopathologyCD30 expression in non‐Hodgkin's lymphoma
107 Citations1990Miguel Á. Piris, D C Brown +2 more
The present results suggest that in a general lymphoma clinic there is probably little justification for differentiating anaplastic large cell lymphomas or CD30+ lymphomas from other high‐grade non‐Hodgkin's lymphomas.
Journal of Investigative DermatologyAtypical Cells in Lymphomatoid Papulosis Express the Hodgkin Cell-Associated Antigen Ki-1
96 Citations1986Peter Kaudewitz, Harald Stein +3 more
Findings provide evidence that the Ki-1 positive cells in LyP represent activated T cells as RS cells do in many cases of Hodgkin's disease (HD).
Journal of Clinical PathologyTwelve cases of Ki-1 positive anaplastic large cell lymphoma of skin.
82 Citations1991Shiladitya Banerjee, J Heald +1 more
Three of the four patients with associated mycosis fungoides had prolonged survival, contrary to the findings of previous reports which suggest secondary Ki-1 ALCL behaves aggressively.
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38 Citations1989Jane S. Lindholm, David R. Barron +2 more
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38 Citations1986Elisabeth Ralfkiær, T. Al Saati +4 more
Investigation of cutaneous non-Hodgkin lymphomas showed similarities with nodal lymphomas in terms of expression of lymphoid subset markers and composition of the non-neoplastic white cell infiltrate, and immunophenotypic investigations form a useful supplement to their histogenetic characterisation and may provide a common conceptual basis for their classification.
Dermatologic ClinicsLymphomatoid Papulosis
38 Citations1985Rein Willemze
The recognition of two histologic types of lymphomatoid papulosis, which are not distinct entities but represent the ends of a spectrum, has provided an explanation for the clinical and histologic variation and many of the current controversies in this disorder.
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31 Citations1989Wolfram Sterry, B Korte +1 more
The characteristics of Pleomorphic T-cell lymphoma and large-cell anaplastic lymphoma are outlined and the clinical, histological, immunological, and ultrastructural features as seen in two typical case histories are described.
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27 Citations2009Emilio Berti, Raffaele Gianotti +1 more
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