Slit and robo: expression patterns in lung development
Gene Expression PatternsPublished 1 March 2003
Mark Anselmo, Sussie Dalvin, Parthak Prodhan, Katsumi Komatsuzaki, Jeremy T. Aidlen, Jay J. Schnitzer
Citations46
SJR quartileQ4
SJR score0.34
SNIP0.37
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TL;DR
Slit/Robo are expressed in temporo-spatially adjacent domains suggesting interactive roles in pulmonary bronchiolar development.
Abstract
First described as an axonal guidance cue through its repulsive effect on neurons expressing its receptor Roundabout (Robo), the Slit ligand has effects on cell migration, axon branching and elongation. Indirect evidence implicates Slit and Robo in lung development. We now demonstrate that Slit-2 and Slit-3 are developmentally regulated in embryonic murine lung. Immunohistochemistry demonstrates Slit-2 and Slit-3 expression by the pulmonary mesenchyme and airway epithelium. Robo-1 and Robo-2 are also expressed by the developing mesenchyme and airway epithelium. As lung development progresses, Robo-1 and Robo-2 expression localizes to only the airway epithelium. We conclude Slit/Robo are expressed in temporo-spatially adjacent domains suggesting interactive roles in pulmonary bronchiolar development.
Keywords
NeuroscienceBiochemistry, Genetics and Molecular Biology
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