Evidence for a Pseudoautosomal Locus for Schizophrenia
The British Journal of PsychiatryPublished 1 July 1992
Philip Gorwood, Marion Leboyer, Thierry d’Amato, Melanie Jay, Dominique Campion, Dominique Hillaire
Citations33
SJR quartileQ1
SJR score2.47
SNIP2.17
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TL;DR
Sibship and pairwise analysis showed there to be an excess of same-sex pairs in paternally derived sibships, as predicted by the pseudoautosomal hypothesis.
Abstract
A locus for schizophrenia within the pseudoautosomal region of chromosomes X and Y has been suggested by Crow on the basis of epidemiological data. The present report replicates this finding in a sample of 38 French multiply affected families with schizophrenia. Sibship and pairwise analysis, with or without weighted-pair correction, with three different systems of family classifications, showed there to be an excess of same-sex pairs in paternally derived sibships, as predicted by the pseudoautosomal hypothesis.
Keywords
Biochemistry, Genetics and Molecular Biology
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