Lactobacillus acidophilus Autolysins Inhibit Helicobacter pylori In Vitro
Current MicrobiologyPublished 1 January 2001Open access
Graciela L. Lorca, Torkel Wadström, Graciela Font de Valdez, Åsa Ljungh
Citations126
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TL;DR
The bactericidal effect of L. acidophilus CRL 639 in mixed cultures is related to a proteinaceous compound released after cell lysis, and the inhibition observed was related to the acid production and the low pH attained.
Abstract
Antibacterial activity of 17 strains of lactobacilli was tested against 10 strains of H. pylori. The inhibition observed was related to the acid production and the low pH attained. No relationship between CagA phenotype of H. pylori strains and tolerance to lactic acid was observed. In mixed cultures, L. acidophilus CRL 639 showed an autolytic behavior after 24 h of culture. At this moment, H. pylori CCUG17874 showed a decrease of 2 log-cycle, and no viable count was detected after 48 h. The bactericidal effect of L. acidophilus CRL 639 in mixed cultures is related to a proteinaceous compound released after cell lysis.
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MedicineAgricultural and Biological SciencesNursing
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