Plasma acth and cortisol levels in benzodiazepine treated rats
Pharmacological Research CommunicationsPublished 1 February 1980
G Bruni, P. Dal Pra, Maria Teresa Dotti, G Segré
Citations41
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TL;DR
In rat a single i.p. administration of various benzodiazepines at doses equivalent to those employed in humans brings about a clear-cut decrease of ACTH levels in plasma, without changes in plasma cortisol levels.
Abstract
In rat a single i.p. administration of various benzodiazepines (bromazepam, chlordiazepoxide, clonazepam, diazepam, flunitrazepam, flurazepam, medazepam, nitrazepam) at doses equivalent to those employed in humans brings about a clear-cut decrease of ACTH levels in plasma, without changes in plasma cortisol levels. The repeated administration (0.5 mg/kg every 24 hours for 4 days) of diazepam, in addition to a decrease of plasma ACTH levels, brings about a decrease in plasma cortisol levels. © 1980 The Italian Pharmacological Society.
Keywords
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