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The Effect of Nisoldipine as Compared with Enalapril on Cardiovascular Outcomes in Patients with Non-Insulin-Dependent Diabetes and Hypertension

New England Journal of MedicinePublished 5 March 1998Open access
Raymond O. Estacio, Barrett W. Jeffers, William R. Hiatt, Stacy L. Biggerstaff, Nancy Gifford, Robert W. Schrier
Citations1,175
SJR quartileQ1
SJR score19.08
SNIP13.47
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TL;DR

In this population of patients with diabetes and hypertension, a significantly higher incidence of fatal and nonfatal myocardial infarction is found among those assigned to therapy with the calcium-channel blocker nisoldipine than among those assign to receive enalapril.

Abstract

In this population of patients with diabetes and hypertension, we found a significantly higher incidence of fatal and nonfatal myocardial infarction among those assigned to therapy with the calcium-channel blocker nisoldipine than among those assigned to receive enalapril. Since our findings are based on a secondary end point, they will require confirmation.

Keywords

Medicine