Production onf matrix metalloproteinase-2 and metalloproteinase-3 related to malignant behavior of esophageal carcinoma. A clinicopathologic study
CancerPublished 15 December 1992Open access
Ichiro Shima, Yasuyuki Sasaguri, Jingo Kusukawa, Hideaki Yamana, Hiromasa Fujita, Teruo Kakegawa
Citations129
SJR quartileQ1
SJR score2.95
SNIP1.90
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
It is suggested that MMP, especially MMP-2 and -3, play an important role in tumor invasion and metastasis and that analysis of MMP-2 and -3 production is useful for evaluation of malignant potential in esophageal carcinoma.
Abstract
These results suggest that MMP, especially MMP-2 and -3, play an important role in tumor invasion and metastasis and that analysis of MMP-2 and -3 production is useful for evaluation of malignant potential in esophageal carcinoma.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
Journal of Histochemistry & CytochemistryUse of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.
14,259 Citations1981S M Hsu, Laurence Raine +1 more
The ABC method, which involves an application of biotin-labeled secondary antibody followed by the addition of avidin-biotin-peroxidase complex, gives a superior result when compared to the unlabeled antibody method.
Proceedings of the National Academy of SciencesCOLLAGENOLYTIC ACTIVITY IN AMPHIBIAN TISSUES: A TISSUE CULTURE ASSAY
1,301 Citations1962Jerome Gross, Charles M. Lapière
The model suggests that lipid plays an essential role and show that even substances which are not intrinsically surface active can have profound effects when the composition of the interfacial phase is suitably chosen, and further studies of its changes of physical state under narcotics may be very informative.
Journal of Biological ChemistryA metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. Purification and characterization.
513 Citations1986Yasunori Okada, Hideaki Nagase +1 more
The identical digestion patterns of reduced, carboxymethylated protein substrates indicated that both active forms of the enzyme have the same substrate specificity, which may play a role in the normal turnover of the connective tissue matrix as well as in the joint destruction of chronic synovitis.
Journal of Biological ChemistryStromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates.
496 Citations1985Jennie R. Chin, Gillian Murphy +1 more
Purified stromelysin degraded casein, cartilage proteoglycans, fibronectin, alpha 1-proteinase inhibitor, and immunoglobulin G2a and had limited activity on laminin, elastin, type IV collagen, and gelatin, but did not degrade type I collagen.
Biochemical JournalStromelysin is an activator of procollagenase. A study with natural and recombinant enzymes
465 Citations1987Gillian Murphy, Mark I. Cockett +3 more
A cascade mechanism is proposed in which collagenase is activated by stromelysin, which causes a further apparent decrease in the Mr of procollagenase.
Annals of SurgeryPrinciples of Surgical Treatment for Carcinoma of the Esophagus
393 Citations1981Hiroshi Akiyama, Masahiko Tsurumaru +2 more
Analysis of lymph nodes demonstrated a widespread distribution of positive lymph nodes regardless of the location of the tumor, particularly in the region of the lesser curvature of the stomach.
PubMedHigh incidence of amplification of the epidermal growth factor receptor gene in human squamous carcinoma cell lines.
368 Citations1986Tadashi Yamamoto, Nobuyuki Kamata +8 more
The results show that amplification of the EGF receptor gene is commonly found in various tumors and suggest that primary squamous cell carcinomas with amplified EGFceptor gene may readily adapt to growth in tissue culture.
Cancer and Metastasis ReviewsRole of collagenases in tumor cell invasion
337 Citations1982Lance A. Liotta, Unnur P. Thorgeirsson +1 more
Collagenases are a family of metalloproteinases which may play a role in facilitating tumor cell invasion of the extracellular matrix and immunologic studies using antibodies specific for collagenase have demonstrated that in vivo, tumor cells can produce collagenase.
Molecular and Cellular BiologyIsolation of the oncogene and epidermal growth factor-induced transin gene: complex control in rat fibroblasts.
331 Citations1986L M Matrisian, Pierre Leroy +3 more
ScienceGrowth Factors Regulate Transin Gene Expression by c- <i>fos</i> -Dependent and c- <i>fos</i> -Independent Pathways
283 Citations1988Lawrence D. Kerr, Jeffrey T. Holt +1 more
Both Fos-dependent and FOS-independent pathways exist for growth factor regulation of gene expression, and both effects may be mediated through the same cis-acting transcription element.
PubMedGrowth-inhibitory effects of epidermal growth factor and overexpression of its receptors on human squamous cell carcinomas in culture.
253 Citations1986Nobuyuki Kamata, Kazuhiro Chida +4 more
It is suggested that EGF and EGF receptors play a role in the development of SCCs because EGF did not inhibit and in some cases slightly stimulated the growth of other tumor cells, such as adenocarcinomas of the stomach, cervix, and breast and sarcomas.
CancerKi-67 immunostaining in human breast tumors and its relationship to prognosis
251 Citations1991Hanns-Olof Wintzer, Irmgard Zipfel +3 more
Ki‐67 labeling was quantified in 37 nonmalignant breast tissues and in 63 breast carcinomas by counting ten random high‐power fields each in three section planes or by evaluation of the area with the highest labeling density, both of which proved to be highly correlated.
Journal of Biological ChemistryPurification and characterization of a murine basement membrane collagen-degrading enzyme secreted by metastatic tumor cells.
243 Citations1983Tuula Salo, Lance A. Liotta +1 more
A type IV collagen-degrading enzyme activity secreted by a highly metastatic mouse tumor was purified by concanavalin A- and typeIV collagen-agarose affinity chromatographies followed by gel filtration on Bio-Gel A-0.5 m, indicating that the enzyme is a hydrophobic protein.
PubMedAugmentation of type IV collagenase, laminin receptor, and Ki67 proliferation antigen associated with human colon, gastric, and breast carcinoma progression.
207 Citations1991Antonietta D’Errico, Spiridione Garbisa +4 more
The proportion of neoplastic cells immunocytochemically positive for type IV collagenase, laminin receptor, and Ki67 proliferation-associated antigen increased during the progression of human colon, gastric, and breast carcinomas.
Biochemical JournalPurification and characterization of matrix metalloproteinase 9 from U937 monocytic leukaemia and HT1080 fibrosarcoma cells
192 Citations1992T. Morodomi, Y. Ogata +3 more
Comparative studies on digestion of gelatin and collagen types IV and V by M MP-9 and MMP-2 indicated that both enzymes degrade these substrates into similar fragments, but the susceptibilities of laminin, fibronectin and reduced carboxymethylated transferrin to these two MMPs were sufficiently different to indicate differences in substrate specificities between these two closely related proteinases.
Biochemical JournalNeutral metallo-proteinases of rabbit bone. Separation in latent forms of distinct enzymes that when activated degrade collagen, gelatin and proteoglycans
145 Citations1978Anthony Sellers, John J. Reynolds +1 more
Rabbit bones in culture produce specific collagenase and neutral metallo-proteinase activity in latent forms that can be activated by either 4-aminophenylmercuric acetate or trypsin, which resolves by gel filtration into two enzymes, distinct from collagenase, that degrade gelatin and cartilage proteoglycans.
International Journal of CancerHigh incidence of egf receptor hyperproduction in esophageal squamous‐cell carcinomas
143 Citations1987Soji Ozawa, Masakazu Ueda +3 more
Unlike previous reports on breast and bladder cancers, this study showed no obvious correlation between these pathological characteristics and the EGF receptor levels in esophageal carcinomas.
Cancer and Metastasis ReviewsCollagenolytic mechanisms in tumor cell invasion
142 Citations1984David E. Woolley
It has been proposed that collagenolytic enzymes are required to facilitate the spread and invasion of tumor cells into host tissues and that local host:tumor cell interactions are important in modulating collagenolysis.
Proceedings of the National Academy of SciencesCoordinate regulation of stromelysin and collagenase genes determined with cDNA probes.
125 Citations1987Steven M. Frisch, E J Clark +1 more
Stromelysin and collagenase mRNA were both induced by phorbol 12-myristate 13-acetate and cytochalasin B at a constant ratio of the two gene products; this suggests coordinate regulation.
CancerSuperficial esophageal carcinoma: Surgical treatment and the results
120 Citations1990Hoichi Kato, Yuji Tachimori +4 more
An esophagectomy with wide lymphadenectomy is necessary to provide a better prognosis for SEC invading the submucosa, whereas a less extensive treatment may be considered for SEC limited to the mucosa.
Biochemical and Biophysical Research CommunicationsGelatinases of metastatic cell lines of murine colonic carcinoma as detected by substrate-gel electrophoresis
116 Citations1988Sadako Yamagata, Yoshika Ito +2 more
Gelatinases were detected in the conditioned medium of murine colonic carcinoma cells by SDS-polyacrylamide gel electrophoresis using gels copolymerized with gelatin and the former activity was markedly increased in highly metastatic cell lines as compared with its activity in poorly metastatic cells.
PubMedStages of neoplastic transformation of human breast tissue as monitored by dissolution of basement membrane components. An immunoperoxidase study.
105 Citations1981Siegal Gp, Barsky Sh +2 more
Results support the concept of basement membrane degradation associated with invasion and suggest that at least some metastatic tumor cells retain the ability to synthesize laminin and type IV collagen, but do not exhibit an extracellular basement membrane.
Collagen and Related ResearchCharacterization of a Specific Antiserum to Rabbit Stromelysin and Demonstration of the Synthesis of Collagenase and Stromelysin by Stimulated Rabbit Articular Chondrocytes
102 Citations1986Gillian Murphy, Rosalind M. Hembry +1 more
An antiserum to rabbit bone stromelysin (proteoglycanase) was raised in sheep and characterized as specific, recognizing the enzyme from both different tissue sources and different species, and was used in the study of metalloproteinase production by rabbit articular chondrocytes stimulated with either interleukin 1 or mononuclear cell-conditioned medium.
AtherosclerosisProduction of tissue collagenase (matrix metalloproteinase 1) by human aortic smooth muscle cells in response to platelet-derived growth factor
91 Citations1991Hidetaka Yanagi, Yasuyuki SASAGURI +3 more
The ability of SMCs to synthesize and secrete proMMP-1 in response to PDGF suggests that this enzyme plays an important role in the migration of PDGF-stimulated SMCs from the media into the intima of aorta and the eventual formation of atherosclerotic plaques.
Journal of Cell ScienceGelatinase (type iv collagenase) immunolocalization in cells and tissues: Use of an antiserum to rabbit bone gelatinase that identifies high and low <i>M</i> <i>r</i> forms
84 Citations1989Gillian Murphy, Rosalind M. Hembry +3 more
The anti-gelatinase antiserum stained cells of the synovial tissue of rabbits at 14 days after induction of an antigen-induced arthritis, demonstrating its usefulness as a tool to assess the role of this enzyme in degradative events.
CancerAssessment of cell proliferation in colorectal carcinomas using the monoclonal antibody KI-67. Correlation with pathohistologic criteria and influence of irradiation
76 Citations1989Rainer Porschen, B Lohe +2 more
CancerCytophotometric dna analysis of mucosal and submucosal carcinoma of the esophagus
66 Citations1984Keizō Sugimachi, Takeshi Okamura +4 more
The results suggest the potential usefulness of cytophotometric DNA analysis for assessing the prognosis, even in the early stage of esophageal carcinoma.
European Journal of Cancer and Clinical OncologyPlasminogen activator and cancer
65 Citations1984Michael J. Duffy, P. O’Grady
Since plasminogen activator is an estradiol-inducible enzyme, its measurement in breast carcinomas might be a marker for a functional estrogen receptor.
British journal of surgeryMultivariate approach for assessing the prognosis of clinical oesophageal carcinoma
63 Citations1988K Sugimachi, H Matsuoka +3 more
Early detection and postoperative care play key roles in determining the survival of patients with oesophageal carcinoma, and three of fifteen variables were associated with the prognosis of patients who underwentOesophagectomy, which proved to be one of the most reliable prognostic factors.
PubMedRegulation by epidermal growth factor of human squamous cell carcinoma plasminogen activator-mediated proteolysis of extracellular matrix.
38 Citations1989Michael J. Niedbala, Alan C. Sartorelli
The observed increase in ECM degradation mediated by EGF in A431 tumor cells was dependent upon the presence of plasminogen and could be inhibited by an anticatalytic uPA monoclonal antibody.
CancerDNA image cytometry. A prognostic tool in squamous cell carcinoma of the esophagus?
35 Citations1991Thomas Boettger, Stefan Störkel +6 more
In 45 patients who underwent an esophagus resection due to a squamous cell carcinoma, in addition to the TNM classification and usual morphologic criteria, the paraffin‐embedded material underwent deparaffinization, was rehydrated, and was mechanically and enzymatically processed into a single‐cell solution.
International Journal of CancerThe relationship of collagenolytic activity to stage of human colorectal carcinoma
33 Citations1987Tatsuro Irimura, Takao Yamori +3 more
Deep and superficial areas of primary tumors released similar type‐IV collagenolytic activity levels, suggesting that there was little intratumoral heterogeneity in the release of this enzyme.
Virchows Archiv B Cell Pathology Including Molecular PathologyCollagenase production by immortalized human aortic endothelial cells infected with simian virus 40
28 Citations1991Yasuyuki Sasaguri, Hidetaka Yanagi +4 more
These immortalized human aortic endothelial cells, which have some characteristics of normal endothelium cells and, like capillary endothelial Cells, have the ability to produce collagenase, will probably prove useful for studies of atherosclerosis and angiogenesis.
PubMedDistribution of type IV collagen in benign and malignant epithelial proliferations. An indirect immunofluorescence study on the breasts, the lungs, and the skin.
24 Citations1984Y. Cam, Georges Bellon +3 more
It is concluded that the loss of type IV collagen seen in malignant proliferations in this study is related to overt or potential tumor cell infiltration and aggressiveness.
Surgery TodayExpression of human epidermal growth factor and its receptor in esophageal cancer
18 Citations1990Hidenori Mukaida, Tetsurou Yamamoto +7 more
The results suggest that hEGF and EGFR show increased production in squamous cell carcinomas and could to be useful prognostic factors in patients with esophageal cancer.
