Modelling cost-effectiveness of Helicobacter pylori screening to prevent gastric cancer: a mandate for clinical trials
The LancetPublished 1 July 1996
Julie Parsonnet, Ryan A. Harris, Howard M. Hack, Douglas K Owens
Citations332
SJR quartileQ1
SJR score12.11
SNIP22.72
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
A cost-effectiveness analysis to estimate the costs and benefits associated with screening for H pylori at age 50 and treating those individuals infected with antibiotics found it potentially cost-effective in the prevention of gastric cancer, particularly in high-risk populations.
Abstract
Screening and treatment for H pylori infection is potentially cost-effective in the prevention of gastric cancer, particularly in high-risk populations. Cancer prevention trials are strongly recommended.
Keywords
Medicine
New England Journal of Medicine<i>Helicobacter pylori</i> Infection and the Risk of Gastric Carcinoma
3,878 Citations1991Julie Parsonnet, Gary Friedman +5 more
Infection with H. pylori is associated with an increased risk of gastric adenocarcinoma and may be a cofactor in the pathogenesis of this malignant condition.
Medical Decision MakingMarkov Models in Medical Decision Making
2,421 Citations1993Frank A. Sonnenberg, J. Robert Beck
The ability of the Markov model to represent repetitive events and the time dependence of both probabilities and utilities allows for more accurate representation of clinical settings that involve these issues.
BMJAssociation between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.
1,392 Citations1991D Forman, D. G. Newell +5 more
H pylori infection may be an important cause of gastric cancer; between 35% and 55% of all cases may be associated with such an infection.
PubMedHelicobacter pylori in peptic ulcer disease.
1,309 Citations2004van Rensburg O
Infection with Helicobacter pylori is very common throughout the world; causes chronic gastritis; predisposes to gastric and duodenal ulcers and is recognised as a class 1 gastric carcinogen.
JAMAHelicobacter pylori in Peptic Ulcer Disease
1,028 Citations1994Tadataka Yamada
It is concluded that ulcer patients with H. pylori infection require treatment with antimicrobial agents in addition to antisecretory drugs whether on first presentation with the illness or on recurrence.
GastroenterologyEpidemiology of Helicobacter pylori in an asymptomatic population in the United States
969 Citations1991David Y. Graham, Hoda M. Malaty +4 more
The prevalence of H. pylori infection among 485 healthy asymptomatic volunteers between the ages of 15 and 80 residing in the Houston metropolitan area was investigated and it was found that having pets was associated with a lower frequency, but this was highly associated with higher socioeconomic status.
New England Journal of MedicinePrevalence of <i>Helicobacter pylori</i> Infection and Histologic Gastritis in Asymptomatic Persons
762 Citations1989Cornelius P. Dooley, Hartley Cohen +5 more
GastroenterologyRelationship of Helicobacter pylori to serum pepsinogens in an asymptomatic Japanese population
629 Citations1992Masahiro Asaka, Toshio Kimura +6 more
The apparent decrease in prevalence of H. pylori accompanying the Westernization of Japan may eventually be accompanied by a reduction in the frequency of atrophic gastritis, the precursor lesion of the epidemic form of gastric carcinoma, and ultimately result in a decrease in the incidence of gastRIC carcinoma in Japan.
PubMedThe incidence of Helicobacter pylori infection.
384 Citations1995Julie Parsonnet
In adults of industrialized countries, an estimated 0.5% of the susceptible population becomes infected each year, and adults who currently harbour the organism are more likely to have been infected in childhood than adulthood.
Gastroenterology Clinics of North AmericaHELICOBACTER PYLORI AND GASTRIC CANCER
348 Citations1993Julie Parsonnet
Because gastric cancer is unusual in the United States, screening and treatment of H. pylori in the general population are unwarranted; Chemoprevention in high-risk populations, however, could potentially be used to decrease risk for adenocarcinomas distal to the cardia.
The LancetDouble-blind placebo-controlled study of the hyperventilation provocation test and the validity of the hyperventilation syndrome
166 Citations1996HK Hornsveld, Bert Garssen +3 more
The HVPT is invalid as a diagnostic test forHyperventilation seems a negligible factor in the experience of spontaneous symptoms, and the term HVS should be avoided.
Journal of Pediatric Gastroenterology and NutritionHelicobacter pylori Infection in Children
125 Citations1993Hazel M. Mitchell, T. D. Bohane +6 more
Although antral nodularity occurs more frequently in children it is not exclusive to childhood, the polymorphonuclear response in children is less than that reported in adults, and peptic ulcer disease is rare in children and the present study would suggest that inChildren it is less frequently associated with H. pylori infection than in adults.
Journal of Gastroenterology and HepatologyThe Sydney System: Epidemiology and natural history of chronic gastritis
114 Citations1991P. Sipponen, M. Kekki +1 more
Both antral and corpus gastritis with coexistent severe atrophic changes have been shown to be associated with an increased risk of gastric cancer, and gastritis seems to also play an important role in the pathogenesis of peptic ulcer.
Alimentary Pharmacology & Therapeutics<i>Metronidazole, omeprazole and clarithromycin: an effective combination therapy for</i> Helicobacter pylori <i>infection</i>
92 Citations1995Mahmoud M. Yousfi, H. M. T. EL‐ZIMAITY +4 more
The effectiveness and side effect profile of two antibiotics active against Helicobacter pylori, metronidazole and clarithromycin, combined with omeprazole are studied.
QJM<italic>Helicobacter pylori eradication</italic>: efficacy and side effect profile of a combination of omeprazole, amoxycillin and metronidazole compared with four alternative regimens
90 Citations1993G. D. Bell, K. POWELL +10 more
Omeprazole/amoxycillin/metronidazole (OAM) therapy was better tolerated than STT (course completion 98.1% vs. 81.4%, p < 0.001) and BTT and LTT were also better toleratedthan STT.
CancerThe time trend and age—period—cohort effects on incidence of adenocarcinoma of the stomach in connecticut from 1955–1989
85 Citations1993Tongzhang Zheng, Susan T. Mayne +6 more
Examination of the incidence pattern of adenocarcinoma of the gastric cardia and distal stomach in Connecticut during the past decades identified components of birth cohort, period, and age as determinants of the observed time trends by regression modeling.
Scandinavian Journal of GastroenterologyEfficacy and Side Effects of a Triple Drug Regimen for the Eradication of Helicobacter pylori
68 Citations1993J C Thijs, Anton A. van Zwet +1 more
This treatment regimen is well tolerated and very effective for the eradication of metronidazole-sensitive H. pylori strains and non-ulcer dyspepsia patients reported significantly more side effects than patients with peptic ulcer disease.
PubMedAccuracy of diagnostic methods used for epidemiological studies of Helicobacter pylori.
53 Citations1995R. A. Feldman, Stephen Evans
The use of multiple tests to augment positive culture as a 'gold standard', has been aided by use of polymerase chain reactions and other molecular biological methods, but this augmentation has its limitations, since each of the additional methods may produce false positives.
Statistics in MedicineDesigning a cost‐effective clinical trial
48 Citations1995John Hornberger, Byron Wm. Brown +1 more
This work calculated sample size considering the costs of implementing the results of the trial and the trial costs using Neyman-Pearson methods and a Bayesian cost-benefit method and illustrates these methods in a clinical trial sponsored by the National Institutes of Health.
EpidemiologyLife Expectancy in Four U.S. Racial/Ethnic Populations
43 Citations1995Robert A. Hahn, Steven C. Eberhardt
Correcting for undercounts by race/ethnicity in the census and on misclassification of race/ ethnicity on death certificates to calculate life expectancy in the United States in 1990 had little effect on life expectancy estimates for whites, but it substantially decreased estimates for American Indians and Asians.
International Journal of EpidemiologyIncreased Risk of <i>Helicobacter pylori</i> Associated with Birth in Wartime and Post-War Japan
39 Citations1996Marilyn L. Replogle, WILLIAM KASUMI +6 more
ScienceSome of the Tough Decisions Required by a National Health Plan
37 Citations1989Louise B. Russell
Studies of the health effects of several major interventions in relation to their costs--Pap smears, mammography, coronary care units, bypass surgery, and cholesterol reduction--indicate the kinds of choices to be made.