Recovery of Human Immunodeficiency Virus From Serum

JAMAPublished 13 March 1987

Barbara Michaelis

DOI10.1001/jama.1987.03390100065011

Source URL

Citations37

SJR quartileQ1

SJR score5.35

SNIP10.71

TL;DR

The results of a survey of serum samples from 78 randomly selected, seropositive individuals were reported, of whom about 30% were asymptomatic, and infectious virus was recovered from the serum of 20 individuals and was generally present in low titers.

Abstract

To the Editor.— Our laboratory has reported the isolation of the human immunodeficiency virus (HIV) from peripheral mononuclear blood cells (PMCs) from over 300 individuals with the acquired immunodeficiency syndrome (AIDS) or AIDS-related conditions and from asymptomatic individuals from the risk groups.1,2We have also isolated the AIDS virus from a variety of body fluids, including serum, plasma, tears, urine, saliva, and genital secretions.3,4We now report the results of a survey of serum samples from 78 randomly selected, seropositive individuals, of whom about 30% were asymptomatic. Infectious virus was recovered from the serum of 20 (25.6%) of these individuals and was generally present in low titers. Only undiluted serum (not a tenfold dilution) yielded infectious virus as detected by assays on uninfected PMCs.2In one serum sample, 25000 infectious particles per milliliter were detected as measured by end dilution of the serum. This sample came from

Keywords

Immunology and MicrobiologyMedicine

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