Comments on review by coleman and flood ‘neuron numbers and dendritic extent in normal aging and alzheimer's disease.’ density measures: Parameters to avoid
Neurobiology of AgingPublished 1 November 1987
Dick F. Swaab, H.B.M. Uylings
Citations49
SJR quartileQ1
SJR score1.45
SNIP0.92
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TL;DR
Alterations in cell numbers in human brain structures of more than a factor or two may be missed when only cell density is measured.
Abstract
Alterations in cell numbers in human brain structures of more than a factor or two may be missed when only cell density is measured.
Keywords
Mathematics
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838 Citations1985Dick F. Swaab, Eric Fliers +1 more
In both sexes a decrease in SCN volume and cell number was observed in senescence (80-100 years) and the latter change was especially pronounced in patients with senile dementia of the Alzheimer type (SDAT), which suggests the presence of a structural defect in the SCN which underlies the general disturbance of biological rhythms insenescence and SDAT.
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Comparison of the different approximation equations and procedures to estimate the volume of a brain region with an irregular shape contained in parallel sections indicates that the 'basic volume estimator' using systematic section is very efficient and sufficiently accurate.
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102 Citations1986Willem A. van Gool, Majid Mirmiran
This chapter summarizes the current knowledge about the circadian system and its organization and provides an overview of chronobiological studies in which age or dementia has been treated as independent variable and indicates possible fruitful future directions of the research related to aging and circadian rhythms.
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