Modeling the Heart
PhysiologyPublished 22 July 2004
Denis Noble
Citations79
SJR quartileQ1
SJR score1.87
SNIP1.73
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TL;DR
Models of the heart have been developed since 1960, starting with the discovery and modeling of potassium channels, and have now reached a high degree of physiological detail.
Abstract
Models of the heart have been developed since 1960, starting with the discovery and modeling of potassium channels. The first models of calcium balance were made in the 1980s and have now reached a high degree of physiological detail. During the 1990s, these cell models were incorporated into anatomically detailed tissue and organ models.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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Three–dimensional computer models of ventricular conduction that combine physiological membrane kinetics with realistic descriptions of myocardial structure and geometry will become more feasible and should illuminate the complex mechanisms underlying the initiation and maintenance of Torsade de Pointes and other arrhythmias.
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25 Citations2002Denis Noble
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