Dendritic spines do not split during hippocampal LTP or maturation
Nature NeurosciencePublished 18 March 2002
John C. Fiala, Brenda A. Allwardt, Kristen M. Harris
Citations124
SJR quartileQ1
SJR score11.20
SNIP4.70
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TL;DR
Reconstruction of dendrites, axons and synapses from hippocampus during long-term potentiation (LTP) and maturation shows long, mature axons passed between neighboring dendritic spine synapses, precluding their formation by splitting.
Abstract
Synapse splitting is considered a viable mechanism for increasing synaptic coupling between neurons1,2,3,4,5. We investigated this issue by reconstructing dendrites, axons and synapses from hippocampus during long-term potentiation (LTP) and maturation. Long, mature axons passed between neighboring dendritic spine synapses, precluding their formation by splitting.
Keywords
Neuroscience
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