A polygenic theory of schizophrenia.
Proceedings of the National Academy of SciencesPublished 1 July 1967
Irving I. Gottesman, James Shields
Citations642
SJR quartileQ1
SJR score3.41
SNIP2.38
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The mystery of the etiology of schizophrenia has been refractory to the analytical methods provided thus far by the biological and social sciences, but no rational therapy with preventative or curative powers, founded on etiological knowledge, has yet appeared.
Abstract
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
Journal of the American Medical AssociationDementia Praecox or the Group of Schizophrenias
4,407 Citations1951Eugen Bleuler
The British Journal of PsychiatryPsychiatric Disorders in Foster Home Reared Children of Schizophrenic Mothers
774 Citations1966Leonard L. Heston
The place of genetic factors in the aetiology of schizophrenia remains disputed, but several surveys have demonstrated a significantly higher incidence of the disorder in relatives of schizophrenic persons as compared to the general population.
The British Journal of PsychiatrySchizophrenia and Social Class
457 Citations1963E. Matilda Goldberg, Shannon L. Morrison
The findings suggest that gross socio-economic deprivation is unlikely to be of major aetiological significance in schizophrenia, and occupational factors appear to exert some influence on the course of the disease.
NatureSchizophrenia as a Genetic Morphism
225 Citations1965A. Hoffer
Huxley, Mayr, Osmond and Hoffer proposed the hypothesis that schizophrenia was a genetic morphism based on three main streams of evidence, but this hypothesis was criticized for being premature.
The British Journal of PsychiatrySchizophrenia in Twins: 16 Years' Consecutive Admissions to a Psychiatric Clinic
112 Citations1966Irving I. Gottesman, James Shields
American Sociological ReviewA Research Note on Diagnosed Mental Illness and Social Class
46 Citations1966H. Warren Dunham, Patricia Phillips +1 more
It is suggested that while schizophrenics in their developmental years are able to show fair educational achievement they are at a distinct disadvantage when they enter the job market.
Journal of Medical GeneticsGenetic factors in diabetes mellitus studied by the oral glucose tolerance test.
38 Citations1965G. S. Thompson
American Journal of PsychiatryGENETIC FACTORS IN SCHIZOPHRENIA
31 Citations1960Ian Gregory
Twin studies suggest that heredity may be slightly more important in predisposing to schizophrenia than in determining intelligence, but these studies are complicated by very serious methodological difficulties, some of which have been discussed.
