Community-Acquired Methicillin-Resistant <i>Staphylococcus aureus</i> Infections: A New Source for Nosocomial Outbreaks
Annals of Internal MedicinePublished 1 September 1982
Louis D. Saravolatz, DONALD J. POHLOD, LUCILLE M. ARKING
Citations300
SJR quartileQ1
SJR score3.38
SNIP3.27
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Over a 19-month period, 165 patients with 183 infections caused by community-acquired, methicillin-resistant Staphylococcus aureus were seen at Henry Ford Hospital in Detroit, Michigan.
Abstract
Over a 19-month period, 165 patients with 183 infections caused by community-acquired, methicillin-resistant Staphylococcus aureus were seen at Henry Ford Hospital in Detroit, Michigan. The proportion of community-acquired staphylococcal infections resistant to methicillin rose from 3 % in March 1980 to 38% in September 1981. Drug abuse, serious underlying illness, previous antimicrobial therapy, and previous hospitalization were all associated with the development of this infection. Concurrent with the community epidemic was a nosocomial epidemic of methicillin-resistant S. aureus infection, which accounted for 30.6% of all nosocomial staphylococcal infections in January 1981. Control measures that included isolation, discharge precautions for carriers, and eradication of employee carriage were effective in preventing nosocomial transmission. The prevalence of methicillin-resistant S. aureus carriage among employees was 0.7%. Methicillin-resistant S. aureus may originate in the community as well as in the hospital, and presents a threat to patients in both settings.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
BiometricsAnalysis of Categorical Data by Linear Models
1,522 Citations1969James E. Grizzle, C F Starmer +1 more
The special cases of linear functions and logarithmic functions of the 7rin are developed in detail, and some examples of how the general approach can be used to analyze various types of categorical data are presented.
New England Journal of MedicineMethicillin-Resistant<i>Staphylococcus aureus</i>at Boston City Hospital
519 Citations1968Fred F. Barrett, R. F. McGehee +1 more
Twenty-two isolates of methicillin-resistant Staphylococcus aureus were obtained from 18 patients; 21 of the strains were phage nontypable, exhibited methiillin resistance to other penicillins and cephalosporins tested, and had characteristics similar to those of previously reported methicillus-resistant strains.
Annals of Internal MedicineMethicillin-Resistant <i>Staphylococcus aureus:</i> Introduction and Spread Within a Hospital
409 Citations1980James E. Peacock, FREDERIC J. MARSIK +1 more
Patients acquiring methicillin-resistant S. aureus in the intensive care unit had a longer mean stay, had higher overall mortality, and received nafcillin and aminoglycosides more frequently than did cohorted control subjects.
The Journal of Infectious DiseasesAn Outbreak of Infections Caused by Strains of Staphylococcus aureus Resistant to Methicillin and Aminoglycosides. I. Clinical Studies
395 Citations1979Kay M. Crossley, Danuta Z. Loesch +4 more
Stains of Staphylococcus aureus resistant to methicillin and multiple aminoglycosides, (designated MARS) were recovered from 108 inpatients with nosocomial infections at a hospital in the midwestern United States, and recovered from the burn wounds of 64%; 32% of the patients with burns had MARS bacteremia.
Annals of Internal MedicineMethicillin-Resistant <i>Staphylococcus aureus</i>
362 Citations1982Louis D. Saravolatz, NORMAN MARKOWITZ +3 more
Infection with strains of methicillin-resistant Staphylococcus aureus occurred in 40 patients at time of admission to a large urban hospital from March to December 1980 and has the potential to disseminate in both settings.
The American Journal of MedicineClinical, epidemiologic and bacteriologic observations of an outbreak of methicillin-resistant staphylococcus aureus at a large community hospital
244 Citations1976Joseph J. Klimek, Frederick J. Marsik +4 more
This outbreak demonstrates the ability of MR-SA not only to colonize many patients in a relatively brief period of time, but also to produce serious disease.
Infection ControlEpidemiologie Studies of an Outbreak of Nosocomial Methicillin-Resistant<i>Staphylococcus aureus</i>Infections
209 Citations1981John M. Boyce, Martha N. Landry +2 more
Patients with burns acquired MRSA more frequently than did other acutely ill surgical patients, and often remained colonized for 30 days or more, and the interval between admission and acquisition of S. aureus, number of antibiotics received, duration of antibiotic therapy before becoming colonized, and cost of hospitalization, were significantly greater in patients with MRSA infection.
The American Journal of MedicineA large outbreak of infections caused by a strain of staphylococcus aureus resistant to oxacillin and aminoglycosides
161 Citations1981Donald E. Craven, Candace C. Reed +5 more
Elderly patients with significant underlying disease, a history of previous surgery or of prior antimicrobial therapy appeared to be at increased risk for OARSA infections, and epidemiologic intervention was effective in controlling this outbreak.
The LancetOUTBREAK OF HOSPITAL INFECTION WITH A STRAIN OF STAPHYLOCOCCUS AUREUS RESISTANT TO GENTAMICIN AND METHICILLIN
153 Citations1976D.C. Shanson, J. G. Kensit +1 more
A previously unreported strain of Staphylococcus aureus, resistant to both gentamicin and methicillin, as well as other antibiotics, caused an outbreak of hospital infection involving 17 patinets and 8 staff.
JAMAAn Outbreak of Methicillin-Resistant Staphylococcus aureus Infection
153 Citations1970Richard D. O'Toole
Spread of staphylococci among patients appeared to have occurred primarily by way of temporary hand carriage by personnel, and the organisms exhibited limited capacity for colonization of patients not receiving antimicrobial agents.
Annals of Internal MedicineStaphylococcal Endocarditis in Parenteral Drug Abusers: Source of the Organism
110 Citations1975Carmelita U. Tuazon, JOHN N. SHEAGREN
Because approximately one third of persons injecting illicit drugs carry Staphylococcus aureus in their nose and throat or on the skin, it was wondered if the carrier was the person in the drug-injecting population at risk of developing endocarditis.
The American Journal of MedicineEradication of epidemic methicillin-gentamicin-resistant staphylococcus aureus in an intensive care nursery
88 Citations1981Lisa M. Dunkle, Shehla H. Naqvi +2 more
With the elimination of the reservoir, no further colonization occurred and antibiotic resistance did not reappear, and standard infection control measures can eliminate epidemics of multiple antibiotic-resistant Staph.
Infection ControlMethicillin-Resistant Staphylococcus Aureus: Interstate Spread of Nosocomial Infections with Emergence of Gentamicin-Methicillin Resistant Strains
86 Citations1980George Saroglou, Margaret Cromer +1 more
The outbreak described here exemplifies a number of potential problems associated with control of nosocomial staphylococcal infections: interhospital spread of methicillin-resistant strains; secondary patient-to-patient intrahospital spread; and emergence of even more resistant strains, possibly associated with selective pressures exerted by widespread use of broad-spectrum antimicrobial agents.
Military MedicineEpidemiologic Investigation of Methicillin Resistant Staphylococcus Aureus in a Burn Unit
53 Citations1978E. Dale Everett, Adolf E. Rahm +3 more
Journal of Antimicrobial ChemotherapyAntibiotic resistance of <i>Staphylococcus aureus</i> in a burns unit after stopping routine prophylaxis with erythromycin
51 Citations1978H. A. Lilly, E. J. L. Lowbury