Liver damage from cocaine in mice
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TL;DR
Massive liver damage and marked elevation of serum glutamic-oxaloacetic transaminase was observed after a single injection of 50 mg per kg cocaine-HC1, which led to increased sleep time after pentobarbital, and a decreased rate of pentobarBital metabolism in vivo.
Abstract
Four daily injections of 20 mg per kg cocaine hydrochloride into B6AF1/J mice produced focal necrosis of liver parenchymal cells in the midzonal region. Massive liver damage and marked elevation of serum glutamic-oxaloacetic transaminase was observed after a single injection of 50 mg per kg cocaine-HC1. This damage led to increased sleep time after pentobarbital, and a decreased rate of pentobarbital metabolism in vivo.