Corticosterone regulates behavioral effects of lipopolysaccharide and interleukin-1 beta in mice
American Journal of Physiology-Regulatory, Integrative and Comparative PhysiologyPublished 1 July 1995
Emmanuelle Goujon, Patricia Parnet, Arnaud Aubert, Glyn Goodall, Robert Dantzer
Citations48
SJR quartileQ2
SJR score0.94
SNIP0.90
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TL;DR
The results suggest that the pituitary-adrenal response to cytokines exerts an inhibitory feedback on the cell targets that mediate the behavioral effects of LPS and IL-1 beta.
Abstract
The modulatory role of endogenous corticoids in the behavioral effects of lipopolysaccharide (LPS) and recombinant human interleukin-1 beta (IL-1 beta) was studied in mice. Adrenalectomy enhanced the depression of social exploration induced by subcutaneous injection of 200 ng of IL-1 beta or 2 micrograms of LPS. This effect was mimicked by an acute injection of the progesterone antagonist RU-38486 (0.25-1 mg). Chronic replacement with a 15-mg corticosterone pellet abrogated the enhanced susceptibility of adrenalectomized animals to 200 ng of IL-1 beta but had only partial protective effects on their response to 400 ng of IL-1 beta and LPS. These results suggest that the pituitary-adrenal response to cytokines exerts an inhibitory feedback on the cell targets that mediate the behavioral effects of LPS and IL-1 beta.
Keywords
Immunology and MicrobiologyPsychologyNeuroscience
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