Prostate Cancer: Screening, Diagnosis, and Management

The presence of positive staining for prostate-specific antigen (PSA) on paraffin-embedded or fresh tissue may provide a clinical and pathologic clue that the adenocarcinoma originated in the prostate.

Abstract

Despite the increase in prostate cancer incidence and detection, substantial controversy still exists about the advisability and effectiveness of screening programs, the most appropriate staging evaluation, and the optimal management of patients with all stages of prostate cancer. Although randomized, prospective studies attempt to address some of these issues, physicians must appreciate inherent ambiguities involved in recommending staging and treatment choices.