NADP+ phosphatase: A novel mitochondrial enzyme
Biochemical and Biophysical Research CommunicationsPublished 1 July 1987
Christoph Richter
Citations18
SJR quartileQ2
SJR score0.75
SNIP0.56
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TL;DR
Mitochondria contain a NADP+ phosphatase in the matrix space and this enzyme may be important for modulation of posttranslational modification of macromolecules in mitochondria.
Abstract
Mitochondria contain a NADP+ phosphatase in the matrix space. This is shown by both incubation of mitochondria and subfractions derived thereof with added NADP+ and by analysis of endogenous pyridine nucleotides after enzymatic oxidation in Ca2+-loaded mitochondria. The apparent KM for NADP+ is about 1.2 mM. NADPH is not a substrate. The enzyme may be important for modulation of posttranslational modification of macromolecules in mitochondria.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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