THE FREQUENCY OF ANTIGEN-SENSITIVE CELLS IN TISSUE TRANSPLANTATION
The Journal of Experimental MedicinePublished 1 March 1969Open access
Norman W. Nisbet, Morten Simonsen, Marek Zaleski
Citations117
SJR quartileQ1
SJR score5.83
SNIP1.99
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
From the frequency of detectable signs of GVH reaction when low doses of donor cells were injected into hosts containing one foreign allele of the B locus it is concluded that 1–2% must be a minimum estimate for the frequencyof antigen-sensitive cells of a given specificity in this system.
Abstract
Graft-vs.-host (GVH) reactions were performed in chicken embryos by intravenous injection of adult chicken blood dilutions, and the result was scored by weighing the spleens as well as by karyological identification of host and donor metaphases. From the frequency of detectable signs of GVH reaction when low doses of donor cells were injected into hosts containing one foreign allele of the B locus it is concluded that 1-2% must be a minimum estimate for the frequency of antigen-sensitive cells of a given specificity in this system. It is not found possible to reconcile the findings with the strictest form of clonal selection which postulates a single receptor specificity per clone of antigen-sensitive cells.
Keywords
MedicineAgricultural and Biological SciencesBiochemistry, Genetics and Molecular Biology
Vanderbilt University Press eBooksThe clonal selection theory of acquired immunity
1,962 Citations1959Frank Macfarlane Burnet
The clonal selection theory of acquired immunity is studied as a theory of selection for immunity in the context of infectious disease.
The Medical Journal of AustraliaHISTOCOMPATIBILITY TESTING, 1972
1,179 Citations1974Ren Ee Chee
It is clear that a HLA typing laboratory will have to provide allele level resolution of HLA data using the most appropriate means available and this will have the greatest impact in terms of offering the best matched donor for the benefit of patients.
The Journal of Experimental MedicineTHE CARRIAGE OF IMMUNOLOGICAL MEMORY BY SMALL LYMPHOCYTES IN THE RAT
196 Citations1966J. L. Gowans, Jonathan W. Uhr
The cells in thoracic duct lymph which carried immunological memory were small lymphocytes, and it was concluded that they gave higher and more rapid antibody responses.
ChromosomaKaryotype studies on Gallus domesticus
85 Citations1965J. Owen
Karyotypes of both male and female avian cells have been prepared and clearly show that the sex chromosome constitution of the female is ZW and that the total chromosome number is at least 78.
Proceedings of the Royal Society of London. Series B, Biological sciencesPathways in the development of liver macrophages: alternative precursors contained in populations of lymphocytes and bone-marrow cells
71 Citations1968J L Boak, G. H. Christie +2 more
It is concluded that liver macrophages derived from either of two different precursors in populations of recirculating lymphocytes and bone marrow cells respectively can proliferate preferentially, according to the nature of the reticulo-endothelial stimulus.
Proceedings of the Royal Society of London. Series B, Biological sciencesQuantitative studies on tissue transplantation immunity. VII. The normal lymphocyte transfer reaction
71 Citations1966L Brent, Peter Medawar
It is reasoned that conventional immunosuppressive agents do not affect any distinctively immunological activity of lymphoid cells: they merely prevent the multiplication of the cells activated in the first episode of the NLT reaction, and therefore the transformation of a ‘normal’ into a sensitized population.
The LancetTHE THYMUS YESTERDAY, TODAY, AND TOMORROW
54 Citations1967J. F. A. P. Miller
It is suggested that the immediate precursor of the haemolysin-forming cell is a cell type, of bone-marrow origin, which is derived neither from thymus cells nor thoracic-duct cells.
The Journal of Experimental MedicinePRIMARY IMMUNE RESPONSE IN GRAFTED CELLS
35 Citations1967Norman W. Nisbet, Morten Simonsen
Physiological ReviewsCurrent Concepts of the Immunological Function of the Thymus
35 Citations1967J. F. A. P. Miller, David Osoba
Novartis Foundation symposiumThe Factor of Immunization: Clonal Selection Theory Investigated by Spleen Assays of Graft‐Versus‐Host Reaction
33 Citations1962Morten Simonsen
The Journal of Experimental MedicineALLOANTIBODY PRODUCTION MEASURED BY PLAQUE ASSAY IN RELATION TO STRONG AND WEAK HISTOINCOMPATIBILITY
26 Citations1966W. H. Hildemann, William Pinkerton
There appears to be no limitation in the weakness of histocompatibility antigens capable of evoking antibodies detectible by plaque assay, and the early 19S antibodies do not appear to be directly involved in allograft rejection.
Immunology and Cell BiologyTOLERANCE AS SHOWN BY THE SIMONSEN REACTION ON THE CHORIOALLANTOIC MEMBRANE
9 Citations1962Henry R. Hilgard, Deborah Burnet +1 more
Experimental Cell ResearchA sex difference in the splenomegaly syndrome in chick embryos injected with adult spleen cells or blood
8 Citations1962J. B. Solomon
Greater splenomegaly in female hosts was also observed when whole blood from Rhode Island Red (RIR) and Light Sussex (LS) donors was injected into WL hosts and when RIR blood was injecting into LS hosts and in allogeneic Brown Leghorn donor/host combinations.
TransplantationPrimary immune response in grafted cells. Dissociation between the proliferation of activity and the proliferation of cells
3 Citations1967N. W. Nisbet, M. Simonsen
The experiments cast doubt on the proposition that cellular proliferation is necessary for development of aPrimary immune response and suggest that there exists an alternative way in which a primary immune response may unfold from involving a few to involving a much larger number of cells.