Adamantyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1
Bioorganic & Medicinal Chemistry LettersPublished 22 July 2005
Steven H. Olson, Susan D. Aster, Kai Brown, Linda Carbin, Donald W. Graham, Anne Hermanowski‐Vosatka
Citations95
SJR quartileQ2
SJR score0.47
SNIP0.60
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TL;DR
Adamantyl triazoles were identified as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) and the synthesis and structure-activity relationships are presented.
Abstract
Adamantyl triazoles were identified as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1). They are active both in in vitro and in in vivo pharmacodynamic models. The synthesis and structure-activity relationships of these inhibitors are presented.
Keywords
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