A polymorphism in the CYP17 gene is associated with male breast cancer
British Journal of CancerPublished 13 August 1999Open access
Irene Young, Kathreena M. Kurian, Chris E. Annink, I. Kunkler, Victoria Anderson, Brian Cohen
Citations95
SJR quartileQ1
SJR score3.14
SNIP1.83
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
Abstract
The CYP17 gene codes for the cytochrome P450c17alpha enzyme that is involved in the synthesis of oestrogens. This case-control study from the South East of Scotland shows that a polymorphism of the CYP17 gene is associated with an increased risk of male breast cancer.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
ScienceA Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene <i>BRCA1</i>
6,105 Citations1994Yoshio Miki, Jeffrey Swensen +43 more
A strong candidate for the 17q-linked BRCA1 gene, which influences susceptibility to breast and ovarian cancer, has been identified by positional cloning methods.
NatureIdentification of the breast cancer susceptibility gene BRCA2
3,655 Citations1995Richard Wooster, Graham R. Bignell +39 more
The identification of a gene in which six different germline mutations in breast cancer families that are likely to be due to BRCA2 are detected, and results indicate that this is the BRC a2 gene.
Nature GeneticsA single BRCA2 mutation in male and female breast cancer families from Iceland with varied cancer phenotypes
529 Citations1996Steinunn Thorlacius, Guðríður H. Ólafsdóttir +7 more
A five base-pair deletion in exon 9 of BRCA2 in an affected male from the male breast cancer family2 is described, indicating a founder effect in this population of males.
Human Molecular GeneticsPolycystic ovaries and premature male pattern baldness are associated with one allele of the steroid metabolism gene CYP17
463 Citations1994Adam Carey, Dawn Waterworth +6 more
Variation in the A2 allele of the CYP17 gene is a significant factor modifying the expression of PCO/MPB in families where it has been demonstrated to segregate as a single gene disorder, but it is excluded as the primary genetic defect.
DNACloning and Sequence of the Human Gene for P450cl7 (Steroid 17α-Hydroxylase/17,20 Lyase): Similarity with the Gene for P450c21
414 Citations1987J Picado-Leonard, Walter L. Miller
The human P450XVIIA1 gene lying on chromosome 10 is cloned and sequenced, which encodes P450c17, a single cytochrome P450 enzyme mediating both 17 alpha-hydroxylase and 17,20 lyase activities in the biosynthesis of steroid hormones.
PubMedMutation analysis of BRCA1 and BRCA2 in a male breast cancer population.
282 Citations1997Lori S. Friedman, Simon A. Gayther +6 more
A population-based series of 54 male breast cancer cases from Southern California were analyzed for germ-line mutations in the inherited breast/ovarian cancer genes, BRCA1 and BRC a2, finding only one of the twomale breast cancer patients carrying a BRCa2 mutation had a family history of cancer, with one case of ovarian cancer in a first-degree relative.
Nature GeneticsA germline mutation in the androgen receptor gene in two brothers with breast cancer and Reifenstein syndrome
251 Citations1992Richard Wooster, Jonathan Mangion +8 more
A family in which two brothers who both developed breast cancer had clinical and endocrinological evidence of androgen resistance is reported, the first report of a germline mutation in a member of the steroid/thyroid hormone receptor superfamily associated with the development of cancer.
PubMedA polymorphism in the CYP17 gene increases the risk of breast cancer.
248 Citations1997Heather Spencer Feigelson, Gerhard A. Coetzee +3 more
It is suggested that the CYP17 genotype may be a biomarker for the onset of ovulation and advanced breast cancer risk.
PubMedCytochrome P450c17alpha gene (CYP17) polymorphism is associated with serum estrogen and progesterone concentrations.
244 Citations1998Heather Spencer Feigelson, L S. Shames +4 more
It is shown that CYP17 genotype is associated with serum hormone levels among 83 young, nulliparous women, and direct evidence of genetic control of serum hormones levels is provided.
BMJCarcinoma of Male Breast in Association with the Klinefelter Syndrome
159 Citations1965Abigail Jackson, S. Muldal +2 more
Although in males there is a relation between gynaecomastia and some endocrine and hepatic disorders, no such relation has been established or noted in cancers of the male breast, in response to therapeutic oestrogen, usually administered for prostatic carcinoma.
Molecular EndocrinologyTissue-Specific, Cyclic Adenosine 3′,5′-Monophosphate-lnduced, and Phorbol Ester-Repressed Transcription from the Human P450c17 Promoter in Mouse Cells
121 Citations1990Steven T. Brentano, J Picado-Leonard +3 more
To study the transcriptional regulation of the human P450c17 gene, 11 plasmids containing serial deletions of its 5' nontranslated region driving expression of the chloramphenicol acetyltransferase (CAT) reporter gene were constructed.
British Journal of CancerNo association between a polymorphism in the steroid metabolism gene CYP17 and risk of breast cancer
115 Citations1998Alison M. Dunning, Catherine S. Healey +7 more
It is concluded that these alleles do not significantly alter breast cancer risk in the English population.
Journal of Cellular BiochemistryGenetic susceptibility to cancer from exogenous and endogenous exposures
75 Citations1996Heather Spencer Feigelson, Ronald K. Ross +4 more
Although prevention trials using antihormone agents are proving successful in some instances, the long‐term control of these cancers necessitates a clearer understanding of the metabolism and transport of the relevant hormone in vivo.
Journal of Cellular BiochemistryThe in vitro trypanocidal activity of N‐substituted <i>p</i>‐benzoquinone imines: Assessment of biochemical structure‐activity relationships using the Hansch approach
25 Citations1984Robert W. Grady, Steven H. Blobstein +5 more
The strong correlation between antineoplastic activity in vivo and trypanocidal activity in vitro suggests a similar mode of action in both cases, and two possible modes of action, which may in fact be related.
