Serum Uric Acid as an Independent Predictor of Early Death After Acute Stroke
Circulation JournalPublished 1 January 2007Open access
Asterios Karagiannis, Dimitri P. Mikhailidis, Κωνσταντίνος Τζιόμαλος, Maria Sileli, Savvas Savvatianos, Anna I. Kakafika
Citations127
SJR quartileQ1
SJR score1.10
SNIP1.33
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Elevated levels of SUA are independently associated with an increased risk of early death in acute stroke and are confirmed on multiple logistic regression analysis.
Abstract
Elevated levels of SUA are independently associated with an increased risk of early death in acute stroke.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
JAMASummary of the Second Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)
27,886 Citations1993Scott M. Grundy
Dairy therapy remains the first line of treatment of high blood cholesterol, and drug therapy is reserved for patients who are considered to be at high risk for CHD, and the fundamental approach to treatment is comparable.
JAMAExecutive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
25,992 Citations2001Evaluation Expert Panel on Detection
The LancetAge-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies
10,121 Citations2002Sarah Lewington, Robert Clarke +3 more
Throughout middle and old age, usual blood pressure is strongly and directly related to vascular (and overall) mortality, without any evidence of a threshold down to at least 115/75 mm Hg.
JAMAPrevalence of the Metabolic Syndrome Among US Adults
6,698 Citations2002Earl S. Ford, Wayne H. Giles +1 more
These results from a representative sample of US adults show that the metabolic syndrome is highly prevalent and the large numbers of US residents with the metabolic Syndrome may have important implications for the health care sector.
New England Journal of MedicineHigh-Dose Atorvastatin after Stroke or Transient Ischemic Attack
2,887 Citations2006The Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Investigators
In patients with recent stroke or TIA and without known coronary heart disease, 80 mg of atorvastatin per day reduced the overall incidence of strokes and of cardiovascular events, despite a small increase in the incidence of hemorrhagic stroke.
Molecular CellAbsence of Monocyte Chemoattractant Protein-1 Reduces Atherosclerosis in Low Density Lipoprotein Receptor–Deficient Mice
1,566 Citations1998Long Gu, Yoshikatsu Okada +5 more
Monocyte chemoattractant protein-1 plays a unique and crucial role in the initiation of atherosclerosis and may provide a new therapeutic target in this disorder.
JAMASerum Uric Acid and Cardiovascular Mortality
1,507 Citations2000Jing Fang, Michael H. Alderman
Increased serum uric acid levels had a positive relationship to cardiovascular mortality in men and women and in black and white persons and stratifying by cardiovascular risk status, diuretic use, and menopausal status confirmed this relationship.
HypertensionElevated Uric Acid Increases Blood Pressure in the Rat by a Novel Crystal-Independent Mechanism
1,298 Citations2001Marilda Mazzali, Jeremy Hughes +7 more
Mild hyperuricemia causes hypertension and renal injury in the rat via a crystal-independent mechanism, with stimulation of the renin-angiotensin system and inhibition of neuronal NO synthase.
Journal of the American Society of NephrologyA Role for Uric Acid in the Progression of Renal Disease
1,295 Citations2002Duk‐Hee Kang, Takahiko Nakagawa +7 more
Hyperuricemia accelerates renal progression in the RK model via a mechanism linked to high systemic BP and COX-2-mediated, thromboxane-induced vascular disease and provides direct evidence that uric acid may be a true mediator of renal disease and progression.
Annals of Internal MedicineSerum Uric Acid and Risk for Cardiovascular Disease and Death: The Framingham Heart Study
1,294 Citations1999Bruce F. Culleton, Martin G. Larson +2 more
The relation of baseline serum uric acid level to incident coronary heart disease events is described and a growing body of laboratory and clinical evidence suggests that uric Acid plays a role in platelet adhesiveness, formation of free radicals, and oxidative stress.
American Journal of Physiology-Renal PhysiologyA causal role for uric acid in fructose-induced metabolic syndrome
1,099 Citations2005Takahiko Nakagawa, Hanbo Hu +10 more
The first evidence that uric acid may be a cause of metabolic syndrome is provided, possibly due to its ability to inhibit endothelial function, as well as a reduced vasodilatory response of aortic artery rings to acetylcholine.
The LancetEffects of cholesterol-lowering with simvastatin on stroke and other major vascular events in 20 536 people with cerebrovascular disease or other high-risk conditions
1,064 Citations2004Rory Collins, Jane Armitage +3 more
The results demonstrate that statin therapy rapidly reduces the incidence not only of coronary events but also of ischaemic strokes, with no apparent effect on cerebral haemorrhage, even among individuals who do not have high cholesterol concentrations.
HypertensionUric Acid Stimulates Monocyte Chemoattractant Protein-1 Production in Vascular Smooth Muscle Cells Via Mitogen-Activated Protein Kinase and Cyclooxygenase-2
790 Citations2003John Kanellis, Susumu Watanabe +9 more
Uric acid regulates critical proinflammatory pathways in VSMCs, suggesting it may have a role in the vascular changes associated with hypertension and vascular disease.
StrokeStatins in Stroke Prevention and Carotid Atherosclerosis
740 Citations2004Pierre Amarenco, Julien Labreuche +2 more
It is found that statins may reduce the incidence of all strokes without any increase in hemorrhagic strokes, and this effect is mainly driven by the extent of between-group LDL-C reduction.
Brain PathologyOxidative Stress in Brain Ischemia
685 Citations1999Seth Love
The findings in recent animal studies are likely to lead to a range of further pharmacological strategies to limit brain injury in stroke patients and to prevent oxidative damage and its consequences after brain ischemia in man.
Archives of Internal MedicineUric Acid Level as a Risk Factor for Cardiovascular and All-Cause Mortality in Middle-aged Men
663 Citations2004Leo Niskanen, David E. Laaksonen +5 more
Serum uric acid levels are a strong predictor of cardiovascular disease mortality in healthy middle-aged men, independent of variables commonly associated with gout or the metabolic syndrome.
StrokeUric Acid Is a Risk Factor for Myocardial Infarction and Stroke
612 Citations2006Michiel J. Bos, Peter J. Koudstaal +3 more
High serum uric acid levels were associated with risk of myocardial infarction and stroke, and associations were stronger in persons without hypertension than in those with hypertension.
HypertensionRelation Between Serum Uric Acid and Risk of Cardiovascular Disease in Essential Hypertension
561 Citations2000Paolo Verdecchia, Giuseppe Schillaci +4 more
In untreated subjects with essential hypertension, raised uric acid is a powerful risk marker for subsequent cardiovascular disease and all-cause mortality.
HypertensionUric Acid, Hominoid Evolution, and the Pathogenesis of Salt-Sensitivity
559 Citations2002Susumu Watanabe, Duk‐Hee Kang +6 more
It is hypothesized that the mutation provided a survival advantage to early hominoids because of the ability of hyperuricemia to maintain blood pressure under low-salt dietary conditions, such as prevailed during the Miocene.
HypertensionSerum Uric Acid and Plasma Norepinephrine Concentrations Predict Subsequent Weight Gain and Blood Pressure Elevation
517 Citations2003Kazuko Masuo, Hideki Kawaguchi +3 more
It is demonstrated that serum uric acid and plasma norepinephrine concentrations predict subsequent weight gain and blood pressure elevation.
New England Journal of MedicineHyperuricemia in Primary and Renal Hypertension
504 Citations1966Paul J. Cannon, William B. Stason +3 more
The present investigation of the population of the Hypertension-Nephritis Clinic of the Presbyterian Hospital in New York City confirms the observation that there is an increased incidence of hyperuricemia among patients with either primary or renal hypertension, treated and untreated.
HypertensionRelations of Serum Uric Acid to Longitudinal Blood Pressure Tracking and Hypertension Incidence
491 Citations2004Johan Sundström, Lisa Sullivan +4 more
Serum UA level was an independent predictor of hypertension incidence and longitudinal BP progression at short-term follow-up in the Framingham Study, and was positively associated with changes in systolic pressure 4 years later.
AtherosclerosisUric acid and serum antioxidant capacity: a reaction to atherosclerosis?
481 Citations2000F. Javier Nieto, Carlos Iribarren +3 more
Kidney InternationalThe impact of serum uric acid on cardiovascular outcomes in the LIFE study
476 Citations2004Aud Høieggen, Michael H. Alderman +16 more
The increase in SUA over 4.8years in the LIFE study was attenuated by losartan compared with atenolol treatment, appearing to explain 29% of the treatment effect on the primary composite end point.
Annals of Internal MedicineSerum Uric Acid in Essential Hypertension: An Indicator of Renal Vascular Involvement
464 Citations1980Franz H. Messerli, EDWARD D. FROHLICH +3 more
The data suggest that heretofore unexplained hyperuricemia in patients with essential hypertension most likely reflects early renal vascular involvement, specially, nephrosclerosis.
American Journal of Kidney DiseasesSignificance of hyperuricemia as a risk factor for developing ESRD in a screened cohort
458 Citations2004Kunitoshi Iseki, Yoshiharu Ikemiya +4 more
Screenees with hyperuricemia were associated with a greater incidence of end-stage renal disease (ESRD), and strategies to control serum uric acid levels in the normal range may reduce the population burden of ESRD.
The LancetCholesterol and all-cause mortality in elderly people from the Honolulu Heart Program: a cohort study
427 Citations2001Irwin J. Schatz, Kamal Masaki +4 more
Data cast doubt on the scientific justification for lowering cholesterol to very low concentrations (<4.65 mmol/L) in elderly people.
StrokeSerum Uric Acid Is a Strong Predictor of Stroke in Patients With Non–Insulin-Dependent Diabetes Mellitus
417 Citations1998Seppo Lehto, Leo Niskanen +2 more
The results indicate that hyperuricemia is a strong predictor of stroke events in middle-aged patients with NIDDM independently of other cardiovascular risk factors.
Circulation JournalRelationship Between Serum Uric Acid Concentration and Insulin Resistance and Metabolic Syndrome
408 Citations2005Tae Yoo, Ki‐Chul Sung +12 more
Serum uric acid concentration was found to be independently correlated with hypertension, insulin resistance and the risk factors of metabolic syndrome, and even those with a serum uric Acid concentration in the normal range showed an increased risk of metabolic Syndrome as serum uri acid concentration increased.
EpidemiologyPrenatal Methylmercury Exposure as a Cardiovascular Risk Factor at Seven Years of Age
388 Citations1999Nicolina Sørensen, Katsuyuki Murata +3 more
It is suggested that prenatal exposure to methylmercury may affect the development of cardiovascular homeostasis, with the mercury effect being stronger in children with lower birth weights.
International Journal of EpidemiologyCholesterol, coronary heart disease, and stroke in the Asia Pacific region
384 Citations2003Asia Pacific Cohort Studies Collaboration
In both Asian and non-Asian populations in the Asia-Pacific region, total cholesterol is similarly strongly associated with the risk of CHD and ischaemic, but not haemorrhagic, stroke.
American Journal of Kidney DiseasesSignificance of hyperuricemia as a risk factor for developing ESRD in a screened cohort
375 Citations2004Kunitoshi Iseki, Yoshiharu Ikemiya +4 more
Journal of Clinical PathologyThe effect of statins versus untreated dyslipidaemia on renal function in patients with coronary heart disease. A subgroup analysis of the Greek atorvastatin and coronary heart disease evaluation (GREACE) study
355 Citations2004Vasilios G. Athyros, D. P. Mikhailidis +5 more
In untreated dyslipidaemic patients with CHD and normal renal function at baseline, CrCl declines over a period of three years and statin treatment prevents this decline and significantly improves renal function, potentially offsetting an additional factor associated withCHD risk.
Archives of Biochemistry and BiophysicsReaction of Uric Acid with Peroxynitrite and Implications for the Mechanism of Neuroprotection by Uric Acid
354 Citations2000Giuseppe L. Squadrito, Rafael Cueto +5 more
The therapeutic effects of uric acid may be related to the scavenging of the radicals CO(*-)(3) and NO(*)(2) that are formed from the reaction of peroxynitrite with CO(2) and may represent a new and viable approach for ameliorating the adverse effects associated with peroxlynitrite in many diseases.
Annals of Internal MedicineSERUM URIC ACID IN RELATION TO AGE AND PHYSIQUE IN HEALTH AND IN CORONARY HEART DISEASE
354 Citations1951Menard M. Gertler, Stanley M. Garn +1 more
The disease most frequently associated with an abnormal uric acid metabolism is gout, and this association is based upon deposits of uric Acid in the joints and connective tissue of gouty pa...
StrokeSerum Urate as an Independent Predictor of Poor Outcome and Future Vascular Events After Acute Stroke
334 Citations2003Christopher J. Weir, Scott Muir +2 more
Higher serum urate levels predicted poor outcome and higher vascular event rates and the role of urate in stroke pathophysiology remains uncertain, but intervention to lower urate may be worth considering.
Arteriosclerosis Thrombosis and Vascular BiologyAssociation Between Serum Uric Acid, Metabolic Syndrome, and Carotid Atherosclerosis in Japanese Individuals
309 Citations2005Nobukazu Ishizaka, Yuko Ishizaka +3 more
The prevalence of metabolic syndrome showed a graded increase according to serum uric acid values in both genders, andUric acid was found to be an independent risk factor for incidence of carotid plaque in men who did not have metabolic syndrome.
European Heart JournalUric acid in chronic heart failure: a marker of chronic inflammation
287 Citations1998Francisco Leyva
Serum uric acid is strongly related to circulating markers of inflammation in patients with chronic heart failure, consistent with a role for increased xanthine oxidase activity in the inflammatory response in Patients with chronicheart failure.
Annals of EpidemiologyRelations of Hyperuricemia with the Various Components of the Insulin Resistance Syndrome in Young Black and White Adults: The CARDIA Study
270 Citations1998Wolfgang Rathmann, Ellen Funkhouser +2 more
The association of hyperuricemia with most aspects of the Insulin Resistance Syndrome may result predominantly from their covariation with adiposity and secondarily with insulin level.
DiabetologiaElevated serum uric acid ? a facet of hyperinsulinaemia
267 Citations1987Michaela Modan, Hillel Halkin +2 more
It is concluded that elevated serum uric acid is a feature of hyperinsulinaemia/insulin resistance.
StrokePrognostic Significance of Uric Acid Serum Concentration in Patients With Acute Ischemic Stroke
260 Citations2002Ángel Chamorro, Vı́ctor Obach +4 more
In patients with acute ischemic stroke, there is a 12% increase in the odds of good clinical outcome for each milligram per deciliter increase of serum uric acid, which reinforces the relevance of oxidative damage in isChemic stroke.
MetabolismElevated serum uric acid levels in metabolic syndrome: an active component or an innocent bystander?
254 Citations2006Sofia Tsouli, Evangelos Liberopoulos +3 more
Lifestyle measures together with the judicious selection of drugs for the treatment of hypertension, dyslipidemia, and insulin resistance associated with MetS may result in a reduction of SUA levels and possibly cardiovascular disease risk.
StrokeAntioxidant Profile and Early Outcome in Stroke Patients
246 Citations2000Antonio Cherubini, Maria Cristina Polidori +7 more
It is suggested that the majority of antioxidants are reduced immediately after an acute ischemic stroke, possibly as a consequence of increased oxidative stress.
American Journal of HypertensionSerum Uric Acid Is a Determinant of Metabolic Syndrome in a Population-Based Study
243 Citations2006Altan Onat, Hüseyin Uyarel +6 more
Abdominal obesity is the main determinant of uric acid variance and an increment of 1 SD in serum uric Acid levels are associated in both sexes with a 35% higher MS likelihood, independent of 10 risk factors related to MS.
Journal of Biomedical ScienceOxidative stress and neurodegenerative disorders
210 Citations1998Albert Y. Sun, Yongmei Chen
StrokeMetabolic Syndrome and the Risk of Stroke in Middle-Aged Men
210 Citations2006Sudhir Kurl, Jari A. Laukkanen +5 more
The risk of any stroke is increased in men with metabolic syndrome, in the absence of stroke, diabetes and cardiovascular disease at baseline, in this population-based cohort study from eastern Finland.
American Journal of Kidney DiseasesEffect of statins versus untreated dyslipidemia on serum uric acid levels in patients with coronary heart disease: a subgroup analysis of the greek atorvastatin and coronary-heart-disease evaluation (GREACE) study
208 Citations2004Vasilios G. Athyros, Moses Elisaf +6 more
Data suggest that SUA level is an independent predictor of CHD recurrent events, thus offsetting an additional factor associated with CHD risk.
StrokePredictors of Stroke in Middle-Aged Patients With Non–Insulin-Dependent Diabetes
205 Citations1996Seppo Lehto, Tapani Rönnemaa +2 more
Evidence is given that previous history of stroke, hypertension, hyperglycemia, and dyslipidemia are strong predictors of stroke in middle-aged patients with NIDDM.
British Journal of Clinical PharmacologyFree radicals and antioxidants in cardiovascular disease
195 Citations1997Simon Maxwell, Gregory Y.H. Lip
Prospective randomized controlled trials of antioxidants in high risk groups are underway to test whether the theoretical promise of a beneficial role for antioxidants in coronary heart disease prevention will be fufilled.
Current Medical Research and OpinionThe prevalence of the metabolic syndrome using the National Cholesterol Educational Program and International Diabetes Federation definitions
188 Citations2005Vasilios G. Athyros, Emmanuel S. Ganotakis +2 more
MetS could be considered as a ‘normal’ variant if it was present in the majority of the population and the vascular risk associated with IDF-defined MetS may be low, raising cost-effectiveness issues.
StrokePredictors of Stroke in Middle-Aged Patients With Non–Insulin-Dependent Diabetes
187 Citations1996SeppoLehto, TapaniRönnemaa +2 more
Evaluated the significance of different cardiovascular risk factors with respect to the incidence of stroke in middle-aged NIDDM patients in eastern and western Finland to find out if they contribute to the risk of stroke.
Nephrology Dialysis TransplantationEffect of statin treatment on renal function and serum uric acid levels and their relation to vascular events in patients with coronary heart disease and metabolic syndrome: A subgroup analysis of the GREek Atorvastatin and Coronary heart disease Evaluation (GREACE) Study
184 Citations2006Vasilios G. Athyros, D. P. Mikhailidis +7 more
StrokeLow Plasma Antioxidant Activity Is Associated With High Lesion Volume and Neurological Impairment in Stroke
178 Citations2000Janne Leinonen, Jukka-Pekka Ahonen +5 more
Assessment of the role of antioxidant activity in cerebral ischemic stroke suggests that the antioxidant activity of plasma may be an important factor providing protection from neurological damage caused by stroke-associated oxidative stress.
Biochemical JournalWhen and why a water-soluble antioxidant becomes pro-oxidant during copper-induced low-density lipoprotein oxidation: a study using uric acid
174 Citations1999Marco Bagnati, C. Perugini +4 more
Results suggest, irrespective of the levels of endogenous alpha-tocopherol, that uric acid may enhance LDL oxidation by reducing Cu(II) to Cu(I), thus making more Cu( I) available for subsequent radical decomposition of lipid peroxides and propagation reactions.
StrokeRelation Between the Metabolic Syndrome and Ischemic Stroke or Transient Ischemic Attack
172 Citations2005Nira Koren‐Morag, Uri Goldbourt +1 more
The presence of the metabolic syndrome, even without diabetes, in patients with pre-existing atherosclerotic vascular disease identifies patients at increased risk for ischemic stroke or TIA.
NeurologyBetter outcome after stroke with higher serum cholesterol levels
168 Citations2000C. Vauthey, Gabriel R. de Freitas +3 more
The authors’ findings suggest that higher levels of cholesterol are associated with a better outcome in the early phase after ischemic stroke.
HypertensionBlood Pressure Indices and Cardiovascular Disease in the Asia Pacific Region
160 Citations2003Carlene M.M. Lawes, Derrick Bennett +6 more
The data suggest that if time or resources are highly constrained, such as in much-needed epidemiologic surveys in developing countries, very little is lost from only measuring SBP.
StrokeInfluence of Metabolic Syndrome and General Obesity on the Risk of Ischemic Stroke
158 Citations2006Hsin‐Jen Chen, Chyi‐Huey Bai +3 more
MS predicted IS and the 2005 NCEP definition showed a stronger dose-response relationship with IS, and adding GOB to the existing MS definition had limited benefit.
High-Dose Atorvastatin after Stroke or Transient Ischemic Attack The Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Investigators*
146 Citations2006Pierre Amarenco, Julien Bogousslavsky +9 more
CirculationLow Serum Cholesterol and Mortality
143 Citations1995Carlos Iribarren, Dwayne Reed +3 more
Results add strength to the reverse-causality proposition that catabolic diseases cause TC to decrease and to the question of whether low TC is a true risk factor or alternatively a consequence of occult disease at the time of TC measurement.
StrokeSuperoxide Dismutase Activity in Serum of Patients With Acute Cerebral Ischemic Injury
134 Citations1997Matthias Spranger, Sebastian Krempien +3 more
The data suggest that the SOD activity in serum is reduced in stroke patients, and replacement of antioxidative activity could be beneficial in the acute treatment of cerebral ischemia.
FEBS LettersAscorbate prevents prooxidant effects of urate in oxidation of human low density lipoprotein
129 Citations1999Peter M. Abuja
Ascorbate appears to have the same anti‐prooxidant effect with other aqueous reductants, which, besides their antioxidant properties, were reported to be conditionally prooxidants.
StrokeComponents of the Metabolic Syndrome and Risk for First-Ever Acute Ischemic Nonembolic Stroke in Elderly Subjects
123 Citations2005Haralampos Milionis, Evangelos C. Rizos +4 more
Stroke patients with the MetSyn showed higher concentrations of triglycerides, lipoprotein(a), uric acid, and fibrinogen, and lower high-density lipop Protein (HDL) cholesterol and apolipoprotein A-I levels, and in the presence of MetSyn, HDL cholesterol loses its protective role against ischemic stroke.
Diabetes CareA Metabolic Syndrome in Whites and African-Americans: The Atherosclerosis Risk in Communities baseline study
115 Citations1996María Inês Schmidt, Bruce Bartholow Duncan +5 more
Clustering of abnormalities consistent with the concept of a metabolic syndrome is present in both white and African-American subjects, with notably large odds of clustering in white women.
StrokeCholesterol Predicts Stroke Mortality in the Women’s Pooling Project
113 Citations2002Richard B. Horenstein, Dean E. Smith +1 more
The results show that cholesterol is a risk factor for nonhemorrhagic stroke death in women <55 years of age and is more strongly associated with mortality in black women < 55 years ofAge than in white women.
QJMAntioxidant capacity after acute ischaemic stroke
108 Citations2002Salah Gariballa
There was some evidence of reduction in TAC, despite increased uric acid concentrations, and deterioration in serum vitamin C levels in ischaemic stroke patients compared with controls.
Current Pharmaceutical DesignEffect on Serum Uric Acid Levels of Drugs Prescribed for Indications other than Treating Hyperuricaemia
107 Citations2005S. Daskalopoulou, V. Tzovaras +2 more
The effect on SUA levels of drugs that are prescribed for indications other than treating hyperuricaemia are considered, to obviate the need for specific treatment (e.g. allopurinol) aimed at loweringSUA levels.
BMJInfluence of cholesterol on survival after stroke: retrospective study
104 Citations1997Alexander Dyker, Christopher J. Weir +1 more
Higher serum total cholesterol concentrations were associated with a reduction in long term mortality after stroke, independent of the type or extent of the stroke, vascular territory, age, and hyperglycaemia–all factors known to influence survival independently after stroke.
European Journal of EpidemiologyPredictors of stroke mortality in elderly people from the general population
104 Citations2001Alberto Mazza, A. C. Pessina +4 more
Some independent predictors usually unrelated to stroke mortality (namely pulse pressure, pre-diabetic IGT, UA and blood electrolytes disorders) have been identified.
Epidemiology and InfectionCohort study of serum total cholesterol and in-hospital incidence of infectious diseases
99 Citations1998Carlos Iribarren, David R. Jacobs +3 more
Data are suggestive of an inverse association, although not entirely consistent, between total cholesterol and incidence of infections either requiring hospitalization or acquired in the hospital.
Diabetes/Metabolism Research and ReviewsElevated serum urate concentration independently predicts poor outcome following stroke in patients with diabetes
87 Citations2005Edward Newman, Fariel S. Rahman +3 more
Investigation of the prognostic significance of elevated serum urate concentration in diabetic subjects following stroke found it to be a predictor of outcome following stroke.
Circulation JournalSerum Level of Uric Acid, Partly Secreted From the Failing Heart, is a Prognostic Marker in Patients With Congestive Heart Failure
86 Citations2006Hiroshi Sakai, Takayoshi Tsutamoto +4 more
High plasma UA level, partly secreted from the failing heart, is a prognostic predictor independent of BNP in patients with CHF, and monitoring a combination of B NP and UA may be useful for the management of patients withCHF.
Journal of the American Geriatrics SocietyLow Total Cholesterol and Increased Risk of Dying: Are Low Levels Clinical Warning Signs in the Elderly? Results from the Italian Longitudinal Study on Aging
74 Citations2003Sonia Brescianini, Stefania Maggi +6 more
The relationship between serum total cholesterol and all‐cause mortality and all-cause mortality is analyzed, taking into account various potential confounders.
Journal of Internal MedicineSerum uric acid levels and risk for acute ischaemic nonembolic stroke in elderly subjects
74 Citations2005Haralampos J. Milionis, Kallirroi Kalantzi +4 more
This data indicates that treatment with a hypouricaemic action has a favourable effect on CV event prevention and elevated serum uric acid levels should be considered as a risk factor for cardiovascular morbidity and mortality.
Circulation JournalC-Reactive Protein Concentration is More Strongly Related to Metabolic Syndrome in Women Than in Men-The Minoh Study-
68 Citations2005Noriyuki Nakanishi, T. Shiraishi +1 more
CRP concentrations are closely related to the MS-like state in both sexes, but an increase in CRP concentration associated with risk factor-clustering is more pronounced in women, particularly non-smokers.
Biochemical JournalWhen and why a water-soluble antioxidant becomes pro-oxidant during copper-induced low-density lipoprotein oxidation: a study using uric acid
66 Citations1999Marco Bagnati, C. Perugini +4 more
StrokeAcute and long-term changes in serum lipids after acute stroke.
66 Citations1990Jean Woo, Christopher Wai Kei Lam +4 more
CirculationEpidemiology of low cholesterol levels in older adults. The Cardiovascular Health Study.
66 Citations1993Teri A. Manolio, Walter H. Ettinger +5 more
Cross-sectional associations with low cholesterol levels differ by sex and suggest poorer health by some measures, and the observed relations with treated diabetes and impaired hepatic synthetic function should be examined for risk of mortality in longitudinal data.
The Journals of Gerontology Series ALow Cholesterol Levels Are Associated With Short-Term Mortality in Older Patients With Ischemic Stroke
63 Citations2004Giovanni Zuliani, Antonio Cherubini +9 more
Short-term mortality following ischemic stroke is higher in older participants with low TC levels, independent of a large number of factors, which might be useful in identifying frail older participants at high risk of stroke short- term mortality.
Annals of EpidemiologyCross-sectional and longitudinal changes in total and high-density-lipoprotein cholesterol levels over a 20-year period in elderly men: The Honolulu heart program
63 Citations1997Robert D. Abbott, Dan S. Sharp +5 more
Differences between men with recent and earlier disease were not statistically significant, although men without coronary disease experienced a significantly smaller decrease in total cholesterol than either of these groups (P < 0.05).
Circulation JournalAssociation of Inflammatory Marker and Highly Sensitive C-Reactive Protein With Aerobic Exercise Capacity, Maximum Oxygen Uptake and Insulin Resistance in Healthy Middle-Aged Volunteers
63 Citations2005Noriyasu Kondo, Masahiro Nomura +3 more
It is suggested that the development of exercising habits increases the maximum oxygen uptake and decreases HOMA-R and reduces the inflammatory marker CRP, suggesting that exercising habit plays an important role in the primary prevention of coronary heart disease.
Kidney InternationalThe impact of serum uric acid on cardiovascular outcomes in the LIFE study
58 Citations2004Stella S. Daskalopoulou, Vasilios G. Athyros +2 more
European Heart JournalUrate predicts subsequent cardiac death in stroke survivors
56 Citations2002Kenneth Wong
Elevated serum urate concentration may be used to stratify risk of future cardiac death after stroke, and appeared to be true even in stroke survivors who were not on diuretic therapy.
Thrombosis and HaemostasisMechanisms of Vascular Damage in Gout and Oxalosis: Crystal Induced, Granulocyte Mediated, Endothelial Injury
56 Citations1983M. A. Boogaerts, Dale E. Hammerschmidt +3 more
The modulation by mono- sodiumurate (MSU) crystals of PMN-endothelial interactions in vitro is studied to have relevance to the understanding of the accelerated atherogenesis of hyperuricemia and the fulminant vasculitis of oxalosis or ethylene glycol poisoning.
Current Medical Research and OpinionUric acid levels and vascular disease
52 Citations2004Stella S. Daskalopoulou, Vasilios G. Athyros +2 more
Evidence showing that serum uric acid (SUA) levels predict the risk for vascular events is extended to consider the SUA-lowering effect of other drugs commonly prescribed in patients with vascular disease (e.g. statins, fibrates and antihypertensive agents).
European Heart JournalPlasma lipids predict myocardial infarction, but not stroke, in patients with established cerebrovascular disease
46 Citations2005Anushka Patel, Mark Woodward +6 more
Lipid variables are associated with the risk of MI, but not recurrent stroke, in patients with established cerebrovascular disease.
The American Journal of MedicineSerum cholesterol levels and in-hospital mortality in the elderly
44 Citations2003Graziano Onder, Francesco Landi +5 more
Among older hospitalized adults, low serum cholesterol levels appear to be an independent predictor of short-term mortality.
PubMedThe fever of gout: urate crystals activate endogenous pyrogen production from human and rabbit mononuclear phagocytes.
43 Citations1983Gordon W. Duff, E Atkins +1 more
It is found that crystalline urate or silica stimulated macrophages but not PMNs to produce EP, without mediation by lymphocytes, suggesting that since EP and IL 1 are probably the same, the known inflammatory effects of IL 1 may contribute to the pathogenesis of acute gout and other crystal-associated human diseases.
Internal MedicineAssociation between Uric Acid and Carotid Atherosclerosis in Elderly Persons
36 Citations2005Ryuichi Kawamoto, Hitomi Tomita +4 more
It is suggested that SUA is a risk factor or marker for ultrasonographically determined IMT.
Acta Neurologica ScandinavicaPlasma lipids and lipoproteins in subtypes of stroke
32 Citations1992Arne Lindgren, Peter Nilsson‐Ehle +2 more
Patients with different subtypes of stroke showed significant differences when compared with each other by analysis of covariance (with adjustment for age, sex, smoking, hypertension and diabetes), whereas high density lipid concentrations were higher in patients with cardioembolic infarcts.
Journal of Biomedical ScienceOxidative Stress and Neurodegenerative Disorders
18 Citations1998Albert Y. Sun, Yongmei Chen
Recent findings indicate several polyphenols and antioxidant drugs are effective in protecting the cells from ROS attack, and further development of these antioxidant molecules may be of value in preventing the development of neurodegenerative diseases.
…
