Molecular Pharmacology of Cocaine: A Dopamine Hypothesis and its Implications
Novartis Foundation symposiumPublished 28 September 2007
Michael J. Kuhar
Citations74
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TL;DR
The reinforcing properties of cocaine have been related to cocaine binding at the dopamine transporter in mesolimbocortical neurons, which is strongly supported in animal studies of drug self-administration, but the extent of its involvement in human drug dependence has not been fully elucidated.
Abstract
The reinforcing properties of cocaine have been related to cocaine binding at the dopamine transporter in mesolimbocortical neurons. The molecular properties of the transporter have been studied in a number of laboratories. While this 'dopamine hypothesis' is strongly supported in animal studies of drug self-administration, the extent of its involvement in human drug dependence has not been fully elucidated.
Keywords
NeuroscienceBiochemistry, Genetics and Molecular Biology
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