Obesity and the risk of myocardial infarction in 27 000 participants from 52 countries: a case-control study
The LancetPublished 1 November 2005
Salim Yusuf, Steven Hawken, Stephanie Ôunpuu, Leonelo E. Bautista, Maria Grazia Franzosi, Patrick Commerford
Citations2,897
SJR quartileQ1
SJR score12.11
SNIP22.72
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Redefinition of obesity based on waist-to-hip ratio instead of BMI increases the estimate of myocardial infarction attributable to obesity in most ethnic groups.
Abstract
Waist-to-hip ratio shows a graded and highly significant association with myocardial infarction risk worldwide. Redefinition of obesity based on waist-to-hip ratio instead of BMI increases the estimate of myocardial infarction attributable to obesity in most ethnic groups.
Keywords
Medicine
BiometricsComparing the Areas under Two or More Correlated Receiver Operating Characteristic Curves: A Nonparametric Approach
22,316 Citations1988Elizabeth R. DeLong, David M. DeLong +1 more
A nonparametric approach to the analysis of areas under correlated ROC curves is presented, by using the theory on generalized U-statistics to generate an estimated covariance matrix.
PubMedObesity: preventing and managing the global epidemic. Report of a WHO consultation.
13,241 Citations2000
The fundamental causes of the obesity epidemic are sedentary lifestyles and high-fat energy-dense diets, both resulting from the profound changes taking place in society and the behavioural patterns of communities as a consequence of increased urbanization and industrialization and the disappearance of traditional lifestyles.
The LancetAppropriate body-mass index for Asian populations and its implications for policy and intervention strategies
12,655 Citations2004
The proportion of Asian people with a high risk of type 2 diabetes and cardiovascular disease is substantial at BMIs lower than the existing WHO cut-off point for overweight (> or =25 kg/m2), but available data do not necessarily indicate a clear BMI cut-offs point for all Asians for overweight or obesity.
The LancetEffect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study
11,970 Citations2004Salim Yusuf, Steven Hawken +9 more
Abnormal lipids, smoking, hypertension, diabetes, abdominal obesity, psychosocial factors, consumption of fruits, vegetables, and alcohol, and regular physical activity account for most of the risk of myocardial infarction worldwide in both sexes and at all ages in all regions.
CirculationGlobal Burden of Cardiovascular Diseases
2,988 Citations2001Salim Yusuf, Srinath Reddy +2 more
An overview of the global burden of atherothrombotic cardiovascular disease is provided and overarching factors influencing variations in CVD by ethnicity and region and the influence of urbanization are described.
Food and Chemical ToxicologyStatistical methods in cancer research. Vol. 1. The analysis of case-control studies
1,725 Citations1983
International Journal of ObesityBody mass index and percent body fat: a meta analysis among different ethnic groups
1,403 Citations1998Paul Deurenberg, Mabel Yap +1 more
The results show that the relationship between percent body fat and BMI is different among different ethnic groups, which should have public health implications for the definitions of BMI cut-off points for obesity, which would need to be population-specific.
JAMAAbdominal Adiposity and Coronary Heart Disease in Women
1,225 Citations1998Kathryn M. Rexrode
The WHR and waist circumference are independently associated with risk ofCHD in women and were independently strongly associated with increased risk of CHD also among women with a BMI of 25 kg/m2 or less.
New England Journal of MedicineAbsence of an Effect of Liposuction on Insulin Action and Risk Factors for Coronary Heart Disease
901 Citations2004Samuel Klein, Luigi Fontana +5 more
JNCI Journal of the National Cancer InstitutePopulation Attributable Risks of Esophageal and Gastric Cancers
791 Citations2003Lawrence S. Engel, W.-H. Chow +13 more
In this population, a few known risk factors account for a majority of esophageal and gastric cancers, and results suggest that the incidence of these cancers may be decreased by reducing the prevalence of smoking, gastric reflux, and being overweight and by increasing the consumption of fruits and vegetables.
PubMedThe regulation of adipose tissue distribution in humans.
647 Citations1996P Björntorp
Results of studies in vitro indicate that this difference is diminished at the menopause, and restored by estrogen substitution, suggesting that the functional effects of estrogens in women are similar to those of T in men, and fits well with physiological, and clinical conditions with increased visceral fat mass.
International Journal of ObesityA pilot study of long-term effects of a novel obesity treatment: omentectomy in connection with adjustable gastric banding
459 Citations2002A. Thörne, Fredrik Lönnqvist +3 more
Omentectomy, when performed together with AGB, has significant positive and long-term effects on the glucose and insulin metabolic profiles in obese subjects.
DiabetologiaLow subcutaneous thigh fat is a risk factor for unfavourable glucose and lipid levels, independently of high abdominal fat. The Health ABC Study
415 Citations2005for the Health ABC Study, Marieke B. Snijder +10 more
Larger subcutaneous thigh fat is independently associated with more favourable glucose (in men) and lipid levels (in both sexes) after accounting for abdominal fat depots, which are associated with unfavourable glucose and lipid Levels.
American Heart JournalPrognostic impact of body weight and abdominal obesity in women and men with cardiovascular disease
349 Citations2005Gilles R. Dagenais, Qilong Yi +4 more
Obesity, particularly abdominal adiposity, worsens the prognosis of patients with CVD; weight reduction program should be integrated in the active management of these patients.
International Journal of ObesityIndependent and opposite associations of waist and hip circumferences with diabetes, hypertension and dyslipidemia: the AusDiab Study
335 Citations2004MB Snijder, Paul Zimmet +4 more
Independent and opposite associations of waist and hip circumference with diabetes, dyslipidemia and less strongly with hypertension in a large population-based survey emphasize that waist and hips circumference are important predictors for the metabolic syndrome and should both be considered in epidemiological studies.
Obesity ResearchA Survey of Genes Differentially Expressed in Subcutaneous and Visceral Adipose Tissue in Men*
325 Citations2004Marie‐Claude Vohl, Robert Sladek +6 more
The identification of a consistent and rather uniform pattern of differentially expressed genes between the two fat depots using multiple array replicates generated new perspectives for future research on regional differences in adipose tissue biology.
The LancetRisk factors for acute myocardial infarction in Indians: a case-control study
322 Citations1996Prem Pais, Janice Pogue +6 more
Smoking cessation, treatment of hypertension, and reduction in blood glucose and central obesity (perhaps through dietary modification) may be important in preventing ischaemic heart disease in Asian Indians.
International Journal of ObesityAbdominal and total adiposity and risk of coronary heart disease in men
296 Citations2001Kathryn M. Rexrode, J. E. Buring +1 more
American Journal of EpidemiologyAdiposity and Mortality in Men
286 Citations2000Inkyung Baik
Findings indicated that the relation between body fat and mortality was influenced by reverse causation and varied by age.
Clinical ScienceSex steroids and insulin resistance
285 Citations2002Callum Livingstone, Mary Collison
Recognition and treatment of sex steroid-associated insulin resistance at an early stage in patients may reduce their risk of developing Type II (non-insulin-dependent) diabetes mellitus, hypertension and dyslipidaemia, and so may improve fertility and reduce cardiovascular risk.
Obesity ResearchLarger Hip Circumference Independently Predicts Health and Longevity in a Swedish Female Cohort
219 Citations2001Lauren Lissner, Cecilia Björkelund +3 more
The present results suggest that collection of hip measurements should not be discontinued in assessment of obesity-related risk status and health promotion, and the strength of the inverse association for large hips generally exceeded the positive association for waist.
Journal of Internal MedicineNarrow hips and broad waist circumferences independently contribute to increased risk of non‐insulin‐dependent diabetes mellitus
211 Citations1997Jacob C. Seidell, Thang S. Han +2 more
Narrow hips and broad waist circumferences independently contribute to increased risk of non‐insulin‐dependent diabetes mellitus.
Obesity ResearchLarger Thigh and Hip Circumferences Are Associated with Better Glucose Tolerance: The Hoorn Study
192 Citations2003Marieke B. Snijder, Joost Dekker +7 more
Thigh circumference in women and hip circumference in both sexes are negatively associated with markers of glucose metabolism independently of the waist circumference, BMI, and age; both fat and muscle tissues may contribute to these associations.
MetabolismRegional differences in triglyceride breakdown in human adipose tissue: Effects of catecholamines, insulin, and prostaglandin E2
178 Citations1991Bjørn Richelsen, Steen B. Pedersen +2 more
Great regional variation in the regulation of lipolysis is found in isolated adipocytes obtained from different fat depots in females, and in vitro data suggest that free fatty acids (FFA) are more readily mobilized from omental adipose tissue than from subcutaneous adiposes tissue.
BiometricsVariance Calculations and Confidence Intervals for Estimates of the Attributable Risk Based on Logistic Models
171 Citations1990Joseph Bénichou, Mitchell H. Gail
Simulations indicate that those asymptotic procedures yield reliable variance estimates and confidence intervals with near nominal coverage in selecting a logistic model that is neither so simplified as to exhibit systematic lack of fit nor so complicated as to inflate the variance of the estimate of AR.
PubMedRegional distribution of muscle and fat mass in men--new insight into the risk of abdominal obesity using computed tomography.
158 Citations1989Jacob C. Seidell, Per Björntorp +4 more
It is concluded that a higher BMI is associated with increased central and peripheral fat stores (but not visceral fat) and increased thigh muscle whereas waist/hip is primarily associated with decreased central fat stores, decreased thigh muscle and reduced physical fitness.
Annals of EpidemiologyBody mass index and mortality among US male physicians
145 Citations2004Umed A. Ajani, Paulo A. Lotufo +6 more
All-cause and cardiovascular mortality was directly related to BMI among middle-aged and elderly men and Advancing age did not attenuate the increased risk of death associated with obesity.
Arteriosclerosis Thrombosis and Vascular BiologyRegional Body Composition Changes Exhibit Opposing Effects on Coronary Heart Disease Risk Factors
142 Citations2004Tomohiro Okura, Yoshio Nakata +2 more
Regional body composition information is important for evaluating improvement of CHD risk factors during weight-reduction treatment for obesity; differential FTs had opposing effects on CHD Risk Factors during weight reduction in obese women.
American Heart JournalINTER-HEART: A global study of risk factors for acute myocardial infarction
140 Citations2001Stephanie Ôunpuu, Abdissa Negassa +1 more
This study has the potential to have a major impact in developing a worldwide strategy for cardiovascular disease prevention, especially in developing countries and nonwhite populations.
MetabolismComputed tomography—determined body composition in relation to cardiovascular risk factors in Indian and matched Swedish males
133 Citations1996Badrul A. Chowdhury, H Lantz +1 more
It is concluded that the metabolic disturbances of Indians are not necessarily dependent on a preponderance of visceral AT, and also that an upper-body muscle distribution-recognized as a new phenotypic companion to the metabolic syndrome-is statistically related to cardiovascular risk factors.
Clinical ScienceSex steroids and insulin resistance
116 Citations2002Callum LIVINGSTONE, Mary COLLISON
Archives of Internal MedicineBody Mass Index and Total and Cardiovascular Mortality in Men With a History of Cardiovascular Disease
52 Citations2004Michael E. Widlansky, Howard D. Sesso +3 more
Elevated BMI may not be strongly associated with total or cardiovascular mortality among men with previously manifested coronary artery disease, as indicated in this study.
Wiley series in probability and statisticsBuilding and Extending Loglinear/Logit Models
5 Citations2002Alan Agresti