Experimentally induced endometriosis in rats: effect on fertility and the effects of pregnancy and lactation on the ectopic endometrial tissue
Fertility and SterilityPublished 1 December 1992
Juan C. Barragán, Jaime Brotons, José Antonio Palacios Ruíz, Pedro Acién
Citations44
SJR quartileQ1
SJR score2.03
SNIP2.05
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TL;DR
It is not pregnancy, but the anestrus condition created by lactation that exerts a beneficial effect on experimentally induced endometriosis in rats, and this condition diminishes pregnancy rate in rats.
Abstract
Experimentally induced endometriosis diminishes pregnancy rate in rats. It is not pregnancy, but the anestrus condition created by lactation that exerts a beneficial effect on experimentally induced endometriosis in rats.
Keywords
Immunology and MicrobiologyPsychologyMedicine
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The successful growth and development of surgically transplanted endometrial tissue in the rat offers a research model that can be used to study those aspects of endometriosis that cannot be adequately investigated in women.
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It was suggested that estrogens might be eliminated in treatment of endometriosis since a decidua may be produced with progestins.
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The increased PGF in peritoneal fluid may alter follicular rupture, ovum transport, corpus luteum function, or implantation, thus representing a mechanism by which endometriosis may cause infertility.
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Pregnancy is suggested as the optimal prophylactic treatment for endometriosis since the symptoms and signs regress during gestation and for varying periods thereafter.
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The observed activity of steroidal and non-steroidal compounds in this study demonstrates the usefulness of a rat model in the study of endometriosis and suggests that inhibiting or eliminating ovarian steroid production alone will not produce a permanent regression of the endometrial explant.
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