Getting connected: analysis and principles of biological networks

Systematic approaches to study large numbers of proteins, metabolites, and their modification have revealed complex molecular networks which provide novel insights in understanding basic mechanisms controlling normal cellular processes and disease pathologies.

Abstract

The execution of complex biological processes requires the precise interaction and regulation of thousands of molecules. Systematic approaches to study large numbers of proteins, metabolites, and their modification have revealed complex molecular networks. These biological networks are significantly different from random networks and often exhibit ubiquitous properties in terms of their structure and organization. Analyzing these networks provides novel insights in understanding basic mechanisms controlling normal cellular processes and disease pathologies.