Polymorphisms of α-adducin and salt sensitivity in patients with essential hypertension
The LancetPublished 1 May 1997
Daniele Cusi, Cristina Barlassina, Tiziana Azzani, Giorgio Casari, Lorena Citterio, Marcella Devoto
Citations526
SJR quartileQ1
SJR score12.11
SNIP22.72
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TL;DR
The findings of significant linkage of the alpha-adducin locus to essential hypertension and greater sensitivity to changes in sodium balance among patients with the mutant allele suggest that alpha- adducin is associated with a salt-sensitive form of essential hypertension.
Abstract
Our findings of significant linkage of the alpha-adducin locus to essential hypertension and greater sensitivity to changes in sodium balance among patients with the mutant allele suggest that alpha-adducin is associated with a salt-sensitive form of essential hypertension. We suggest the alpha-adducin polymorphism may identify hypertensive patients who will benefit from diuretic treatment or manoeuvres to reduce total body sodium.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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