Use of Flavor‐Amplified Foods to Improve Nutritional Status in Elderly Persons
Annals of the New York Academy of SciencesPublished 1 June 1989
Susan S. Schiffman, Zoe S. Warwick
Citations46
SJR quartileQ1
SJR score1.46
SNIP1.73
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Clinical studies suggest that the addition of odors to foods to compensate for diminished chemosensory functioning is often helpful in increasing intake of nutrient-dense foods in older persons.
Abstract
Impairment of taste and smell perception can lead to decreased food intake in the elderly. The losses in chemosensory functioning can result from normal aging, disease state, drugs, and environmental pollutants. Experimental investigations are underway to develop practical taste enhancers. Clinical studies suggest that the addition of odors to foods to compensate for diminished chemosensory functioning is often helpful in increasing intake of nutrient-dense foods in older persons.
Keywords
NeuroscienceNursingEngineering
The Journal of PhysiologyThe physiological activity of adenine compounds with especial reference to their action upon the mammalian heart1
1,481 Citations1929A. N. Drury, A. Szent-Györgyi
It seemed possible by using this transient disturbance of the heart beat as a biological test to isolate the responsible substance, and by enquiring into its chemical nature to obtain some idea of one of the chemical factors involved in cell function not only in the heart but in the body generally.
Journal of NeurochemistryADENOSINE REGULATES VIA TWO DIFFERENT TYPES OF RECEPTORS, THE ACCUMULATION OF CYCLIC AMP IN CULTURED BRAIN CELLS
1,372 Citations1979Dietrich van Calker, Margarete Müller +1 more
In cell cultures of glial character derived from perinatal mouse brain adenosine elicits two effects; at submicromolar concentrations it inhibits the increase in the intracellular level of cyclic AMP caused by β‐adrenoceptor agonists and at concentrations above micromolar it increases the level of CyclicAMP in the cultures.
American Journal of Physiology-Cell PhysiologyAmiloride: a molecular probe of sodium transport in tissues and cells
841 Citations1982Dale Benos
This drug is the most potent and specific inhibitor of Na+ entry found to date and thus affords the opportunity to be used as a label for the isolation of these transport moieties.
JAMAProtein Status of General Surgical Patients
813 Citations1974Bruce R. Bistrian
In a survey of the protein nutritional status of all patients on the surgical wards of an urban municipal hospital, accepted standards indicated moderate to severe protein-calorie malnutrition in one half of these patients as judged by triceps skin fold and arm muscle circumference measurements.
New England Journal of MedicineTaste and Smell in Disease
446 Citations1983Franklin H. Epstein, Susan S. Schiffman
Neurobiology of AgingAnorexia in the elderly
379 Citations1988John E. Morley, Andrew Silver
Animal studies have suggested that older rodents have an excessive satiety effect of cholecystokinin and a decreased opioid feeding drive, and in Alzheimer's disease, decreases in norepinephrine and neuropeptide Y may be involved in the anorexia seen in the patients.
ScienceAlterations in L-Glutamate Binding in Alzheimer's and Huntington's Diseases
333 Citations1985J. Timothy Greenamyre, John B. Penney +4 more
Brain sections from patients who had died with senile dementia of the Alzheimer's type (SDAT), Huntington's disease (HD), or no neurologic disease were studied by autoradiography to measure sodium-independent L-[3H]glutamate binding.
ScienceDrug and Neurotransmitter Receptors in the Brain
276 Citations1984Solomon H. Snyder
Biochemical investigation of receptors for neurotransmitters and drugs in the brain has been one of the most active areas of molecular neuroscience during the past decade and provided useful probes for drug discovery programs.
Proceedings of the National Academy of SciencesAmiloride reduces the taste intensity of Na+ and Li+ salts and sweeteners.
266 Citations1983Susan S. Schiffman, E Lockhead +1 more
Application of amiloride to the human tongue reduced the taste intensity of sodium and lithium salts and of sweeteners ranging widely in chemical structure, consistent with the position that an amILoride-sensitive transport mechanism is involved in taste perception of sodium, lithium, and saccharides.
Journal of GerontologyFood Recognition by the Elderly
181 Citations1977Susan S. Schiffman
The elderly subjects were significantly less able to identify the foods than young subjects and commented on the weakness of the smell or taste of the foods, indicating more discrimination among foods for young subjects compared with the elderly.
The Journal of General PhysiologyThe active ion transport properties of canine lingual epithelia in vitro. Implications for gustatory transduction.
152 Citations1984John A. DeSimone, Gerard L. Heck +2 more
Evidence is provided that the sodium taste receptor is most probably a sodium transport system, specifically adapted to the dorsal surface of the tongue, and that sodium is absorbed under symmetrical conditions.
Neurobiology of AgingAlzheimer's disease may begin in the nose and may be caused by aluminosilicates
135 Citations1986Eugene Roberts
A speculative sequence of events is suggested by which neuronally-contained aluminosilicates might cleave or otherwise alter a normal cellular protein in such a manner that aggregates would arise that could interfere with cellular function and which also could act in a pseudo-infective manner, relaxing translational and transcriptional controls in the synthesis of the native protein.
European Journal Of Oral SciencesLocation and variation in number of taste buds in human fungiform papillae
111 Citations1979Kristina Arvidson
Serial sections of 182 fungiform papillae, obtained at autopsy from 22 individuals aged 2 days to 90 years, were examined by light microscopy with regard to location and number of taste buds, and the taste buds were always found on the convex, dorsal surface of the papilla but otherwise failed to display any preferential location pattern.
PubMedQuantitative study of taste buds in fungiform and circumvallate papillae of young and aged rats.
75 Citations1984Charlotte M. Mistretta, Bruce J. Baum
Both anatomical investigations and human taste threshold studies indicate that age-related differences in the gustatory system are not as substantial as investigators have suggested in the past.
Neurobiology of AgingFlavor enhancement of foods for the elderly can reverse anorexia
73 Citations1988Susan S. Schiffman, Zoe S. Warwick
Impairment of the senses of taste and smell is one of the major factors contributing to anorexia in the elderly.
American Journal of Physiology-Cell PhysiologySalt and acid studies on canine lingual epithelium
73 Citations1985Sidney A. Simon, Jeffrey L. Garvin
Pharmacology Biochemistry and BehaviorMethyl xanthines enhance taste: Evidence for modulation of taste by adenosine receptor
56 Citations1985Susan S. Schiffman, James M. Gill +1 more
The results suggest that the inhibitory A1 adenosine receptor plays an important local role in taste perception.
The Anatomical RecordAge does not affect numbers of taste buds and papillae in adult rhesus monkeys
56 Citations1985Robert M. Bradley, Hazel M. Stedman +1 more
Since taste bud numbers and general morphology are maintained even in old age, any age‐related differences in taste behavior cannot be attributed to gross degenerative changes in lingual taste buds.
Pharmacology Biochemistry and BehaviorCaffeine intensities taste of certain sweeteners: Role of adenosine receptor
39 Citations1986Susan S. Schiffman, C. Vergara Díaz +1 more
The results suggest that the inhibitory A1 adenosine receptor plays an important local role in modulating the taste intensity of certain sweeteners and that several transduction mechanisms mediate sweet taste.
Pharmacology Biochemistry and BehaviorTransport pathways in rat lingual epithelium
35 Citations1988Sidney A. Simon, R. Robb +1 more
Measurements of ion transport across isolated lingual epithelium of rat were correlated with electrophysiological recordings from taste nerves, suggesting that events in taste transduction can be understood, in part, by measuring the epithelial responses of isolated rat tongue.
Physiology & BehaviorBretylium tosylate enhances salt taste
27 Citations1986Susan S. Schiffman, Sidney A. Simon +2 more
Bretylium tosylate (BT), an antifibrillary drug, was found to potentiate the taste of NaCl and LiCl in both humans and rats and amiloride became ineffective in inhibiting taste responses to NaCl in the presence of BT.
Neurobiology of AgingThe nose as a port of entry for aluminosilicates and other pollutants: possible role in Alzheimer's disease
2 Citations1986Susan S. Schiffman