Brain mechanisms of pain affect and pain modulation
Current Opinion in NeurobiologyPublished 1 April 2002
Pierre Rainville
Citations626
SJR quartileQ1
SJR score2.54
SNIP1.27
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TL;DR
Activity within the anterior cingulate cortex and possibly in other classical limbic structures, appears to be closely related to the subjective experience of pain unpleasantness and may reflect the regulation of endogenous mechanisms of pain modulation.
Abstract
Recent animal studies reveal ascending nociceptive and descending modulatory pathways that may contribute to the affective-motivational aspects of pain and play a critical role in the modulation of pain. In humans, a reliable pattern of cerebral activity occurs during the subjective experience of pain. Activity within the anterior cingulate cortex and possibly in other classical limbic structures, appears to be closely related to the subjective experience of pain unpleasantness and may reflect the regulation of endogenous mechanisms of pain modulation.
Keywords
PsychologyMedicineNeuroscience
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69 Citations1997Juri D. Kropotov, Helen J. Crawford +1 more
The present study is the first to demonstrate the involvement of the anterior cingulate cortex and the anterior temporal cortex in the control of pain with hypnotically suggested analgesia.
NeuroscienceThe organization of lateral ventromedial thalamic connections in the rat: a link for the distribution of nociceptive signals to widespread cortical regions
64 Citations2001Christèle Desbois‐Mouthon, Luis Villanueva
The findings suggest that lateral ventromedial thalamic neurons could be part of a spino-reticulo-thalamo-cortical network that allows signals of pain from any part of the body surface to spread across widespread cortical areas.
NeuropsychobiologySubjective Ratings of Pain Correlate with Subcortical-Limbic Blood Flow: An fMRI Study
62 Citations2001Frank Schneider, Ute Habel +5 more
Functional magnetic resonance imaging was used to measure pain-related changes in cerebral activity during painful stimulation with a strong affective component, and indicated signal increases in subcortical-limbic regions, particularly in the amygdala.
NeuroscienceMu and kappa1 opioid-stimulated [35S]guanylyl-5′-o-(γ-thio)-triphosphate binding in cynomolgus monkey brain
44 Citations1999Laura J. Sim‐Selley, James B. Daunais +2 more
The applicability of [35S]GTPgammaS autoradiography to examine receptor-activated G-proteins in the primate brain and reveal functional mu and kappa1 opioid receptor activity that may contribute to the reported central nervous system effects of opiates are demonstrated.
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