Nonsteroidal anti-inflammatory drug-associated gastropathy: Incidence and risk factor models
The American Journal of MedicinePublished 1 September 1991
James F. Fries, Catherine A. Williams, D. Blöch, Beat A. Michel
Citations357
SJR quartileQ1
SJR score1.00
SNIP1.04
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Knowledge of the risk factors for NSAID-associated gastropathy and their inter-relationships provides a tool for identification of the patient at high risk and for initiation of appropriate therapeutic action.
Abstract
Knowledge of the risk factors for NSAID-associated gastropathy and their inter-relationships provides a tool for identification of the patient at high risk and for initiation of appropriate therapeutic action.
Keywords
MedicinePharmacology, Toxicology and Pharmaceutics
BiometricsClassification and Regression Trees.
23,841 Citations1984Alexander Gordon, Leo Breiman +3 more
Annals of Internal MedicineNonsteroidal Anti-inflammatory Drug Use and Increased Risk for Peptic Ulcer Disease in Elderly Persons
764 Citations1991Marie R. Griffin, Joyce M. Piper +3 more
The data support other findings indicating that a clinically significant risk for serious ulcer disease is associated with the use of nonaspirin nonsteroidal anti-inflammatory drugs and that use of these drugs may be responsible for a large proportion of peptic ulcers among elderly persons.
GutNon-steroidal anti-inflammatory drugs and life threatening complications of peptic ulceration.
631 Citations1987C P Armstrong, A L Blower
There appears to be a relationship between the development of a life threatening complication of peptic ulceration and NSAID ingestion and much of the associated mortality and morbidity may be potentially avoidable.
The LancetNON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND BLEEDING PEPTIC ULCER
545 Citations1986K W Somerville, Gail Faulkner +1 more
Differences in drug intake were evident for both gastric and duodenal ulcer, and are likely to be important in view of the widespread use of these drugs in elderly people.
Arthritis & RheumatismSurvival, prognosis, and causes of death in rheumatoid arthritis
439 Citations1986Donald M. Mitchell, Patricia W. Spitz +4 more
It is indicated that rheumatoid arthritis, a chronic disabling disease, is also associated with a major decrease in survivorship, and treatment with gold or prednisone did not seem to affect survivorship or cause of death.
Annals of Internal MedicineNonsteroidal Anti-inflammatory Drugs and Peptic Ulcer Disease
401 Citations1991Andrew H. Soll, Wilfred M. Weinstein +2 more
Nonsteroidal anti-inflammatory drugs thus appear both to exacerbate an underlying peptic diathesis and to cause de novo ulcers.
GastroenterologyToward an Epidemiology of Gastropathy Associated With Nonsteroidal Antiinflammatory Drug Use
391 Citations1989James F. Fries, Stephen R. Miller +4 more
It is estimated that the syndrome of NSAID-associated gastropathy can be estimated to account for at least 2600 deaths and 20,000 hospitalizations each year in patients with rheumatoid arthritis alone.
Archives of Internal MedicineThe Association of Nonsteroidal Anti-inflammatory Drugs With Upper Gastrointestinal Tract Bleeding
298 Citations1987Jeffrey L. Carson
Non-steroidal anti-inflammatory drugs are associated with UGI bleeding, although the magnitude of the increased risk is reassuringly small, and a linear dose-response relationship and a quadratic duration- response relationship were demonstrated.
Arthritis & RheumatismThe beneficial outcomes of the arthritis self‐management course are not adequately explained by behavior change
230 Citations1989Kate Lorig, Mitchel J. Seleznick +4 more
Evaluation of the Arthritis Self-Management Course revealed significant positive changes in the practice of behaviors that were taught and in health outcomes, but only weak associations between changes in behavior and changes in health status were demonstrated.
Archives of Internal MedicineThe Relative Gastrointestinal Toxicity of the Nonsteroidal Anti-inflammatory Drugs
218 Citations1987Jeffrey L. Carson
It is concluded that there are significant and consistent differences in the incidence of UGI tract bleeding associated with the use of NSAIDs in this population of Medicaid patients in the states of Michigan and Minnesota.
Archives of Internal MedicineNonsteroidal Anti-inflammatory Drug Gastropathy
190 Citations1987Sanford H. Roth
Since endoscopy is an expensive, not always utilized procedure, it is important to identify the population most at risk for appropriate cytoprotective management as well as modification of the anti-inflammatory therapy program.
Social Science & MedicineLong-term outcomes of an arthritis self-management study: Effects of reinforcement efforts
154 Citations1989Kate Lorig, Halsted R. Holman
The findings indicate that the effects of a self-care intervention were sustained over 20 months and that the tested forms of reinforcement did not alter those effects.
Archives of Internal MedicineMisoprostol Heals Gastroduodenal Injury in Patients With Rheumatoid Arthritis Receiving Aspirin
130 Citations1989S. Roth
Misoprostol, coadministered with aspirin, is well tolerated and highly effective in healing aspirin-associated gastroduodenal lesions in patients with rheumatoid arthritis without altering the therapeutic benefits of aspirin.
The American Journal of MedicineFrom experiment to experience: Side effects of nonsteroidal anti-inflammatory drugs
127 Citations1983L. Stephen Coles, James F. Fries +2 more
The American Journal of MedicineSucralfate treatment of nonsteroidal anti-inflammatory drug-induced gastrointestinal symptoms and mucosal damage
111 Citations1987Jacques R. Caldwell, Sanford H. Roth +5 more
GutRandomised study of the influence of non-steroidal anti-inflammatory drugs on the treatment of peptic ulcer in patients with rheumatic disease.
89 Citations1987Claus Manniche, A Malchow-Møller +8 more
The outcome of ulcer treatment did not differ in patients with rheumatoid arthritis and patients suffering from osteoarthritis and the influence of continued NSAID administration during peptic ulcer therapy was observed.
Journal of Clinical GastroenterologyCurrent Peptic Ulcer Time Trends
80 Citations1988John H. Kurata, Edward D. Corboy
Current time trends for peptic ulcers are examined, finding that duodenal and gastric ulcer death rates have remained fairly constant since 1979 and hospitalizations for uncomplicated cases continue to decline, but there has been no decrease in cases with complications.
PubMedARAMIS (the American Rheumatism Association Medical Information System). A prototypical national chronic-disease data bank.
53 Citations1986James F. Fries, Dennis J. McShane
ARAMIS is a prototype of a national chronic-disease data-bank system consisting of parallel, longitudinal, clinical data sets from 17 diverse locations; the data describe the courses of thousands of patients with rheumatic disease followed over many years.
PubMedCimetidine in the treatment of gastric ulcer induced by steroidal and nonsteroidal anti-inflammatory agents.
45 Citations1981LoIudice Ta, Tahia H. Saleem +1 more
It is concluded that a regimen of cimetidine plus intensified antacid therapy is far superior to the same dose of antacid alone in the treatment of gastric ulcer induced by anti-inflammatory agents.
Pharmacotherapy The Journal of Human Pharmacology and Drug TherapyCertain Nonsteroidal Antiinflammatory Drugs and Hospitalization for Upper Gastrointestinal Bleeding
40 Citations1985Hershel Jick, Andrew D. Feld +1 more
It is suggested that NSAIDs (excluding aspirin) rarely cause gastrointestinal bleeding from the stomach that requires hospitalization in people below the age of 65 years, and formal analysis is unnecessary.
Drug Information JournalThe ARAMIS (American Rheumatism Association Medical Information System) Post-Marketing Surveillance Program
21 Citations1985James F. Fries
Differences found in specific toxicity, both clinical and laboratory, between different drugs and with drug combinations are important, and these differences had not been discoverable from pre-marketing studies.
PubMedInfluence of age and disease state in nonsteroidal antiinflammatory drug associated gastric bleeding.
18 Citations1988Llewellyn Jg, Pritchard Mh
It is found that patients with chronic inflammatory disease had 2-3 times the expected bleeding incidence, but while there was a definite trend towards an age related risk in older patients, this was not statistically significant.
PubMedPostmarketing surveillance in rheumatology: analysis of purpura and upper abdominal pain.
11 Citations1988James F. Fries, D. Blöch +4 more
A system of postmarketing surveillance of antirheumatic drugs employing prospective protocol based consecutive patient cohorts using recursive partitioning techniques for statistical adjustment for potentially confounding variables and an analysis of 2 side effects (purpura and upper abdominal pain) is presented.