Anaphylactoid reactions to intravenous N-acetylcysteine: a prospective case controlled study
Accident and Emergency NursingPublished 11 October 2003
Richard Lynch, Robert Robertson
Citations73
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TL;DR
It appears that anaphylactoid reactions to intravenous N-acetylcysteine are more likely to occur in high-risk patients, when plasma paracetamol concentrations were found to be below the treatment lines and in late presenters.
Abstract
We report a substantially higher incidence of anaphylactoid reactions to intravenous N-acetylcysteine than has previously been documented. It appears that these reactions are more likely to occur in high-risk patients, when plasma paracetamol concentrations were found to be below the treatment lines and in late presenters. Perhaps, giving the loading dose of N-acetylcysteine over 60 min could reduce the incidence of adverse reactions.
Keywords
MedicineNursingPharmacology, Toxicology and Pharmaceutics
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Intravenous acetylcysteine was more effective than cysteamine and methionine and noticeably free of adverse effects and is the treatment of choice for paracetamol poisoning.
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67 Citations1984D. Nicholas Bateman, K.W. Woodhouse +1 more
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