Evidence for prescribing exercise as therapy in chronic disease
Scandinavian Journal of Medicine and Science in SportsPublished 1 February 2006Open access
Bente Klarlund Pedersen, Bengt Saltin
Citations1,382
SJR quartileQ1
SJR score1.49
SNIP1.55
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TL;DR
The evidence for prescribing exercise therapy in the treatment of metabolic syndrome‐related disorders (insulin resistance, type 2 diabetes, dyslipidemia, hypertension, obesity), heart and pulmonary diseases, muscle, bone and joint diseases, and cancer, depression, asthma and type 1 diabetes is presented.
Abstract
Considerable knowledge has accumulated in recent decades concerning the significance of physical activity in the treatment of a number of diseases, including diseases that do not primarily manifest as disorders of the locomotive apparatus. In this review we present the evidence for prescribing exercise therapy in the treatment of metabolic syndrome-related disorders (insulin resistance, type 2 diabetes, dyslipidemia, hypertension, obesity), heart and pulmonary diseases (chronic obstructive pulmonary disease, coronary heart disease, chronic heart failure, intermittent claudication), muscle, bone and joint diseases (osteoarthritis, rheumatoid arthritis, osteoporosis, fibromyalgia, chronic fatigue syndrome) and cancer, depression, asthma and type 1 diabetes. For each disease, we review the effect of exercise therapy on disease pathogenesis, on symptoms specific to the diagnosis, on physical fitness or strength and on quality of life. The possible mechanisms of action are briefly examined and the principles for prescribing exercise therapy are discussed, focusing on the type and amount of exercise and possible contraindications.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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The LancetBlood pressure, stroke, and coronary heart disease
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A sufficiently high risk of stroke (perhaps because of age, blood pressure, or, in particular, history of cerebrovascular disease) may be the clearest indication for antihypertensive treatment.
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The effectiveness of a range of interventions that include diet or physical activity components, or both, designed to prevent obesity in children is evaluated to determine overall certainty of the evidence.
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The benefits of exercise-based cardiac rehabilitation within the context of today's cardiovascular service provision are confirmed, independent of coronary heart disease diagnosis, type of cardiac rehabilitation, dose of exercise intervention, length of follow-up, trial quality, and trial publication date.
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Exercise remains a cornerstone therapy for the primary prevention, treatment, and control of HTN and angiotensin converting enzyme (ACE) inhibitors and calcium channel blockers are currently the drugs of choice for recreational exercisers and athletes who have HTN.
Diabetes CareThe Finnish Diabetes Prevention Study (DPS)
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Physiological ReviewsExercise and the Immune System: Regulation, Integration, and Adaptation
1,685 Citations2000Bente Klarlund Pedersen, Laurie Hoffman‐Goetz
Con considerations of the clinical ramifications of exercise in the prevention of diseases for which the immune system has a role is of importance, and the interactions between exercise and infectious diseases as well as exercise and neoplasia within the context of both aging and nutrition are addressed.
New England Journal of MedicineEffects of the Amount and Intensity of Exercise on Plasma Lipoproteins
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Current Atherosclerosis ReportsDiabetes and cardiovascular disease
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CirculationRegular physical exercise and low-fat diet. Effects on progression of coronary artery disease.
1,344 Citations1992Gerhard Schüler, Rainer Hambrecht +8 more
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Arthritis & RheumatismThe mortality of rheumatoid arthritis
1,324 Citations1994Frederick Wolfe, Donald M. Mitchell +8 more
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CirculationImpaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus.
1,115 Citations1993Michael T. Johnstone, Shelly J. Creager +4 more
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CirculationRandomized, Controlled Trial of Long-Term Moderate Exercise Training in Chronic Heart Failure
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Journal of the Royal Society of MedicineA Report–Chronic Fatigue Syndrome: Guidelines for Research
1,029 Citations1991Michael Sharpe
Clinical DiabetesClinical Practice Recommendations
997 Citations2011Michael J. Fowler
This final article will focus on summarizing recommendations from the American Diabetes Association and integrating them as a set of clinical practice guidelines for prevention of diabetes itself and of the complications of diabetes and diabetes treatments.
The LancetResults at 1 year of outpatient multidisciplinary pulmonary rehabilitation: a randomised controlled trial
939 Citations2000Timothy Griffiths, M L Burr +10 more
For patients chronically disabled by obstructive pulmonary disease, an intensive, multidisciplinary, outpatient programme of rehabilitation is an effective intervention, in the short term and the long term, that decreases use of health services.
JAMAA Randomized Trial Comparing Aerobic Exercise and Resistance Exercise With a Health Education Program in Older Adults With Knee Osteoarthritis
936 Citations1997Walter H. Ettinger
The data suggest that exercise should be prescribed as part of the treatment for knee osteoarthritis, and modest improvements in measures of disability, physical performance, and pain from participating in either an aerobic or a resistance exercise program.
DiabetologiaImpaired endothelium-dependent and independent vasodilation in patients with Type 2 (non-insulin-dependent) diabetes mellitus
917 Citations1992Gary E. McVeigh, G. Brennan +6 more
Evidence is provided for endothelial and smooth muscle dysfunction in diabetes which may have important therapeutic implications in patients with Type 2 (non-insulin-dependent) diabetes mellitus and in control subjects, using venous occlusion plethysmography.
CirculationEffects of intensive multiple risk factor reduction on coronary atherosclerosis and clinical cardiac events in men and women with coronary artery disease. The Stanford Coronary Risk Intervention Project (SCRIP).
883 Citations1994William L. Haskell, Edwin L. Alderman +8 more
Intensive multifactor risk reduction conducted over 4 years favorably altered the rate of luminal narrowing in coronary arteries of men and women with coronary artery disease and decreased hospitalizations for clinical cardiac events.
The FASEB JournalMuscle‐derived interleukin‐6: mechanisms for activation and possible biological roles
872 Citations2002Mark A. Febbraio, Bente Klarlund Pedersen
It appears that intramuscular IL‐6 is stimulated by complex signaling cascades initiated by both calcium (Ca2+) ‐dependent and ‐independent stimuli, and it also seems likely that skeletal muscle produces IL‐ 6 to aid in maintaining metabolic homeostasis during periods of altered metabolic demand such as muscular exercise or insulin stimulation.
New England Journal of MedicineDrug Treatment of Lipid Disorders
847 Citations1999Robert H. Knopp
Arteriosclerosis of the coronary and peripheral vasculature is the leading cause of death among men and women in the United States and worldwide and nationwide; nationwide, the mortality rate for cardiovascular disease is approximately 50 percent.
Archives of Internal MedicineImplications of Small Reductions in Diastolic Blood Pressure for Primary Prevention
805 Citations1995Nancy R. Cook
A small reduction of 2 mm Hg in DBP in the mean of the population distribution, in addition to medical treatment, could have a great public health impact on the number of CHD and stroke events prevented.
Obesity ResearchExercise‐Induced Reduction in Obesity and Insulin Resistance in Women: a Randomized Controlled Trial
696 Citations2004Robert Ross, Ian Janssen +8 more
Daily exercise without caloric restriction was associated with substantial reductions in total fat, abdominal fat, visceral fat, and insulin resistance in women and exercise without weight loss was also associated with a substantial reduction in total and abdominal obesity.
New England Journal of MedicineChanges in Plasma Lipids and Lipoproteins in Overweight Men during Weight Loss through Dieting as Compared with Exercise
684 Citations1988Peter D. Wood, Marcia L. Stefanick +11 more
It is concluded that fat loss through dieting or exercising produces comparable and favorable changes in plasma lipoprotein concentrations, and none of these changes were significantly different between dieters and exercisers.
JAMAEffects of Exercise Training on Left Ventricular Function and Peripheral Resistance in Patients With Chronic Heart Failure
678 Citations2000Rainer Hambrecht
In patients with stable chronic heart failure, exercise training is associated with reduction of peripheral resistance and results in small but significant improvements in stroke volume and reduction in cardiomegaly.
Archives of Internal MedicineEffects of the Amount of Exercise on Body Weight, Body Composition, and Measures of Central Obesity
641 Citations2004Cris A. Slentz, Brian D. Duscha +7 more
Findings strongly suggest that, absent changes in diet, a higher amount of activity is necessary for weight maintenance and that the positive caloric imbalance observed in the overweight controls is small and can be reversed by a modest amount of exercise.
Acquire (CQUniversity)ACSM's resource manual for Guidelines for exercise testing and prescription
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Exercise training significantly reduced the local expression of TNF-alpha, IL-1-beta,IL-6, and iNOS in the skeletal muscle of CHF patients, suggesting that the local anti-inflammatory effects of exercise may attenuate the catabolic wasting process associated with the progression ofCHF.
Obesity ReviewsDoes physical activity prevent weight gain – a systematic review
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Before new methods to improve exercise adherence are found, the role of prescribed physical activity in prevention of weight gain remains modest.
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Interventions designed to encourage adoption of an exercise regimen must be responsive to the individual's current stage of readiness and focus efforts on moving the individual through the various "stages of change."
Cochrane Database of Systematic ReviewsExercise for treating fibromyalgia syndrome
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Supervised aerobic exercise training has beneficial effects on physical capacity and FMS symptoms and research on the long-term benefit of exercise for FMS is needed.
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593 Citations1999Ingmar Wolff, J.J. van Croonenborg +3 more
The weighted OTs for the RCTs showed very consistently that the exercise training programs prevented or reversed almost 1% of bone loss per year in both LS and FN for both pre- and postmenopausal women, which gives an indication of the confounding introduced by the nonrandom allocation of the subjects to groups.
The Journal of PhysiologyMuscle‐derived interleukin‐6: possible biological effects
592 Citations2001Bente Klarlund Pedersen, Adam Steensberg +1 more
Muscle‐derived IL‐6 is released into the circulation during exercise in high amounts and is likely to work in a hormone‐like fashion, exerting an effect on the liver and adipose tissue, thereby contributing to the maintenance of glucose homeostasis during exercise and mediating exercise‐induced lipolysis.
British Medical BulletinBlood pressure, antihypertensive drug treatment and the risks of stroke and of coronary heart disease
589 Citations1994Rory Collins, Stephen MacMahon
Evidence from observational studies and randomised trials of antihypertensive drug treatment are more relevant to assessing how rapidly, and to what extent, the epidemiologically expected reductions in stroke or in coronary heart disease are produced by suddenly lowering blood pressure in middle and old age.
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559 Citations2004Christian K. Roberts, R. James Barnard
The effects of exercise and diet in the prevention of chronic disease are discussed, the effects of lifestyle modification for both mitigating disease progression and reversing existing disease are highlighted, and potential mechanisms for beneficial effects are suggested.
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Training from three to five times per week during 30--60 min per session at an intensity of about 40--50% of net maximal exercise performance appears to be effective with regard to blood pressure reduction, and the evidence that higher intensity exercise would be less effective is at present inconsistent.
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553 Citations2000George A. Kelley, Kristi S. Kelley
It was concluded that progressive resistance exercise is efficacious for reducing resting systolic and diastolic blood pressure in adults, however, a need exists for additional studies that limit enrollment to hypertensive subjects as well as analysis of data with an intention-to-treat approach before the effectiveness ofgressive resistance exercise as a nonpharmacological intervention can be determined.
Arthritis & RheumatismEfficacy of physical conditioning exercise in patients with rheumatoid arthritis and osteoarthritis
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The aquatics and walking exercise groups showed significant improvement over the control group in aerobic capacity, 50-foot walking time, depression, anxiety, and physical activity after the 12-week exercise program.
Journal of Clinical InvestigationInhibition and stimulation of nitric oxide synthesis in the human forearm arterial bed of patients with insulin-dependent diabetes.
527 Citations1992Alison Calver, Joe Collier +1 more
Evidence is provided for an abnormality of basal nitric oxide-mediated dilatation in the forearm arterial bed of patients with insulin-dependent diabetes mellitus, and it is suggested that the vascular smooth muscle is less sensitive toNitric oxide.
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There is evidence of beneficial effects of exercise therapy in patients with OA of the hip or knee, however, the small number of good studies restricts drawing firm conclusions.
American Journal of Clinical NutritionAging, body composition, and lifestyle: the Fels Longitudinal Study
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413 Citations1994Bess H. Marcus, Laurey R. Simkin
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404 Citations1992Jun Wei, Haimin Xu +2 more
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Journal of the American College of CardiologySkeletal Muscle Function and Its Relation to Exercise Tolerance in Chronic Heart Failure
396 Citations1997Derek Harrington, Stefan D. Anker +5 more
In patients with chronic HF, quadriceps maximal isometric strength is reduced and muscular atrophy becomes a major determinant of exercise capacity and is an independent predictor of peak absolute VO2.
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390 Citations2005Edmund Cauza, Ursula Hanusch‐Enserer +10 more
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Journal of the American College of CardiologyPhysical training improves skeletal muscle metabolism in patients with chronic heart failure
384 Citations1993Stamatis Adamopoulos, Andrew J.S. Coats +9 more
European Journal of Cancer CareA randomized trial of exercise and quality of life in colorectal cancer survivors
379 Citations2003Kerry S. Courneya, Christine M. Friedenreich +4 more
The data suggest that increased cardiovascular fitness is associated with improvements in QOL in colorectal cancer survivors but better controlled trials are needed.
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361 Citations2000Robert Ross, Damon Dagnone +5 more
Clinical ScienceVertebral Bone Loss: An Unheeded Side Effect of Therapeutic Bed Rest
359 Citations1983B. Krølner, B Toft
It is suggested that the simple therapeutic bed-rest regimen leads to excessive vertebral bone loss and recurrent bed- rest periods may predispose to spinal osteoporosis.
The American Journal of CardiologyEffect of exercise training in 60- to 69-year-old persons with essential hypertension
348 Citations1989James M. Hagberg, Scott J. Montain +2 more
Low- intensity training may lower BP as much or more than moderate-intensity training in older persons with essential hypertension, but the underlying mechanisms are unclear.
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346 Citations1995Kathleen Potempa, Martita A. Lopez +4 more
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Journal of Bone and Mineral ResearchThe effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women
339 Citations1995Richard L. Prince, Amanda Devine +6 more
The implementation of a simple public health regimen to prevent age‐related bone loss with calcium supplementation either by calcium tablet or by milk powder is supported and suggests a site‐specific effect of physical activity on bone density in addition to its possible effect to prevent fracture by maintenance of muscle strength and coordination.
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339 Citations1992K Simpson, K. J. Killian +3 more
Weightlifting training may be successfully used in patients with chronic airflow limitation, with benefits in muscle strength, exercise endurance, and subjective responses to some of the demands of daily living.
Scandinavian Journal of RheumatologyEffects of Aerobic Exercise Versus Stress Management Treatment in Fibromyalgia
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AE was the overall most effective treatment, despite being subject to the most sceptical patient attitude prior to the study, and there were no obvious group differences in symptom severity.
PubMedRecreational physical activity and ten-year weight change in a US national cohort.
329 Citations1993D F Williamson, J H Madans +4 more
Data from the NHANES-I Epidemiologic Follow-up Study suggest that low physical activity may be both a cause and a consequence of weight gain
Journal of the American College of CardiologyLow intensity exercise training in patients with chronic heart failure
312 Citations1995Romualdo Belardinelli, Demetrios Georgiou +3 more
Patients with stable chronic heart failure can achieve significant improvement in functional capacity from a low intensity exercise training regimen that involves an increase in mitochondrial density, which reflects an improvement in oxidative capacity of trained skeletal muscles.
International Journal of EpidemiologyAssociation of leisure time physical activity with the risk of coronary heart disease, hypertension and diabetes in middle-aged men and women
311 Citations1997N. Haapanen, Seppo Miilunpalo +3 more
A preventive effect of leisure time physical activity on CHD, hypertension and diabetes is suggested and this effect may differ among middle-aged men and women and the relative importance of the total amount and the intensity may vary depending on the outcome measure.
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308 Citations2001Robert Ross, Ian Janssen
Limited evidence suggests that exercise-induced weight loss is associated with reductions in abdominal obesity as measured by waist circumference or imaging methods; however, at present there is insufficient evidence to determine a dose-response relationship between physical activity, and abdominal or visceral fat.
Journal of Consulting and Clinical PsychologyEffects of four maintenance programs on the long-term management of obesity.
306 Citations1988Michael G. Perri, David McAllister +4 more
All four conditions that combined behavior therapy with a posttreatment maintenance program yielded significantly greater long-term weight losses than behavior therapy alone.
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Aerobics, weight bearing and resistance exercises are all effective in increasing the BMD of the spine in postmenopausal women and walking is also effective on the hip.
Journal of the American Geriatrics SocietyExercise and Weight Loss in Obese Older Adults with Knee Osteoarthritis: A Preliminary Study
291 Citations2000Stephen P. Messier, Richard F. Loeser +5 more
If a combined dietary and exercise intervention would result in significant weight loss in older obese adults with knee osteoarthritis and to compare the effects of exercise plus dietary therapy with exercise alone on gait, strength, knee pain, biomarkers of cartilage degradation, and physical function.
BMJEffects of aerobic exercise on depression: a controlled study.
287 Citations1985Egil W. Martinsen, Asgeir Medhus +1 more
Long term catheterisation should be considered only when other methods to promote continence and provide comfort have failed, and expensive "long life" silicon catheters are inappropriate in most long stay patients.
Journal of Applied PhysiologyRandomized trial of progressive resistance training to counteract the myopathy of chronic heart failure
286 Citations2001Charles T. Pu, Meredith T. Johnson +6 more
High-intensity progressive resistance training improves impaired skeletal muscle characteristics and overall exercise performance in older women with CHF and is largely explained by skeletal muscle and not resting cardiac adaptations.
JAMAVitamins for Chronic Disease Prevention in Adults
273 Citations2002Robert H. Fletcher, Kathleen M. Fairfield
Doctors should make specific efforts to learn about their patients' use of vitamins to ensure that they are taking vitamins they should, and avoiding dangerous practices such as high doses of vitamin A during pregnancy or massive doses of fat-soluble vitamins at any age.
Archives of Physical Medicine and RehabilitationThe effects of a physical training program on patients with osteoarthritis of the knees
272 Citations1998Henrik Røgind, Birgitte Bibow-Nielsen +4 more
General physical training appears to be beneficial to patients with OA of the knee, as shown by the high compliance and low dropout frequency, and such a program is feasible even in patients with severe OAof the knee.
DiabetesEffects of Physical Training and Diet Therapy on Carbohydrate Metabolism in Patients with Glucose Intolerance and Non-insulin-dependent Diabetes Mellitus
271 Citations1984Clifton Bogardus, Éric Ravussin +4 more
In both groups, the improvements in fasting plasma glucose and meal tolerance appeared to be attributable mostly to decreased BEGP, with increased hepatic sensitivity to insulin, however, glucose disposal was accomplished by different mechanisms in the two groups.
PubMedThe effect of aerobic exercise on self-esteem and depressive and anxiety symptoms among breast cancer survivors.
270 Citations1998Michelle Segar, Victor L. Katch +6 more
Mild to moderate aerobic exercise may be of therapeutic value to breast cancer survivors with respect to depressive and anxiety symptoms but not to self-esteem.
Journal of the American College of CardiologyPhysical training modulates proinflammatory cytokines and the soluble Fas/soluble Fasligand system in patients with chronic heart failure
269 Citations2002Stamatis Adamopoulos, John Parissis +8 more
Physical training reduces plasma levels of proinflammatory cytokines and the sFas/sFasL system in patients with CHF and these immunomodulatory effects may be related to the training-induced improvement in functional status of patients withCHF.
CirculationSkeletal muscle metabolism during exercise under ischemic conditions in congestive heart failure. Evidence for abnormalities unrelated to blood flow.
268 Citations1988Barry M. Massie, Michael Conway +6 more
The results indicate that in many patients with congestive heart failure exercising muscle exhibits increased glycolytic metabolism and appears to be metabolically less efficient in relation to external work performed, and cannot be explained by impaired blood flow or oxygen delivery alone.
BMJStrategies for prevention of osteoporosis and hip fracture.
264 Citations1991M R Law, Nicholas Wald +1 more
On the basis of the present incidence, almost one women in four living to the age of 90 in England can expect to have a hip fracture.
DiabetesInsulin-Stimulated Muscle Glucose Clearance in Patients With NIDDM: Effects of One-Legged Physical Training
259 Citations1995Flemming Dela, Jens Jørn Larsen +4 more
It is concluded that training increases insulin action in skeletal muscle in control subjects and NID DM patients, and in NIDDM patients normal values may be obtained, as the increase in trained muscle cannot fully account for the increase for whole-body GCR.
The American Journal of MedicineEffect of an energy-restrictive diet, with or without exercise, on lean tissue mass, resting metabolic rate, cardiovascular risk factors, and bone in overweight postmenopausal women
258 Citations1993Ole Lander Svendsen, Christian Hassager +1 more
Overweight postmenopausal women benefit from addition of combined aerobic and anaerobic exercise to an energy-restrictive diet, and the diet itself has a positive effect on cardiovascular risk factors.
Arthritis & RheumatismBiofeedback/relaxation training and exercise interventions for fibromyalgia: A prospective trial
258 Citations1998Susan P. Buckelew, Robert Conway +11 more
This study demonstrates that these 3 treatment interventions result in improved self-efficacy for physical function which was best maintained by the combination group.
Arthritis & RheumatismA randomized, controlled trial of exercise and education for individuals with fibromyalgia
252 Citations1999S. E. Gowans, A. deHueck +2 more
The program produced significant improvements in 6-minute walk distance, well-being, fatigue, self-efficacy (for controlling pain and other symptoms), and knowledge, but gains in fatigue and knowledge were lost.
JAMAExercise Training and the Cardiovascular Consequences of Type 2 Diabetes and Hypertension
251 Citations2002Kerry J. Stewart
The current evidence, albeit not fully confirmed in randomized trials, suggests that the benefits of exercise training go beyond the recognized benefits of glycemic control and blood pressure reduction and may improve endothelial vasodilator function.
Comprehensive PsychiatryComparing aerobic with nonaerobic forms of exercise in the treatment of clinical depression: A randomized trial
247 Citations1989Egil W. Martinsen, Asle Hoffart +1 more
The study indicates that the antidepressive effects associated with exercises are not restricted to aerobic forms of training, and the correlation between increase in physical fitness and reduction in depression scores was low.
Annals of SurgeryIntermittent Claudication—Surgical Reconstruction or Physical Training?
246 Citations1989Fredrik Lundgren, Ann‐Gret Dahllöf +3 more
The results demonstrate that, compared with physical training alone, operation alone or in combination with subsequent training are superior treatment modalities in patients with intermittent claudication.
PubMedAn exercise program in the treatment of fibromyalgia.
246 Citations1996L. Martin, Arni Nutting +4 more
Exercise is helpful in the management of FM in the short term and it also shows that FM patients can undertake an exercise program which includes aerobic, flexibility, and strength training exercises without adverse effects.
American Journal of Physiology-Endocrinology and MetabolismComparison of techniques to estimate total body skeletal muscle mass in people of different age groups
234 Citations1999David N. Proctor, Peter C. O’Brien +2 more
The results indicate that DXA and urinary creatinine excretion give different results regarding the decline in total body muscle mass with aging, and changes in body water may be an important contributor.
Journal of Personality and Social PsychologyInfluence of aerobic exercise on depression.
229 Citations1984I. Lisa McCann, David S. Holmes
The results indicated that subjects in the aerobic exercise condition evidenced reliably greater improvements in aerobic capacity than did the subjects in either of the other conditions (p less than .002 in both cases).
Obesity ReviewsInterventions for preventing obesity in childhood. A systematic review
223 Citations2001Karen Campbell, Elizabeth Waters +2 more
This research highlights the need to understand more fully the role that physical activity and diet play in the development of obesity and its impact on health in both short‐ and long‐term.
ThoraxPhysical rehabilitation for the chronic bronchitic: results of a controlled trial of exercises in the home.
217 Citations1977C R McGavin, Suyashvi Gupta +2 more
The study demonstrates that a simple training scheme which can be administered from a hospital clinic or family doctor's surgery is safe, feasible, and of benefit to the chronic bronchitic.
European Heart JournalExperience from controlled trials of physical training in chronic heart failure. Protocol and patient factors in effectiveness in the improvement in exercise tolerance
216 Citations1998
A tailored, moderate, home-based, combined cycle ergometer, plus calisthenic exercise training seems safe and beneficial in a large cohort of heart failure patients, with similar benefits in a variety of conditions and different hospital settings.
The American Journal of CardiologyEffect of exercise on upper and lower extremity endothelial function in patients with coronary artery disease
215 Citations2002Noyan Gokce, Joseph A. Vita +7 more
It is suggested that exercise improves endothelial function in peripheral conduit arteries of patients with CAD and that the beneficial effect may be more marked in the vascular beds of the exercised limbs.
PubMedA randomized controlled trial of muscle strengthening versus flexibility training in fibromyalgia
215 Citations2000Kim Dupree Jones
Patients with FM can engage in a specially tailored muscle strengthening program and experience an improvement in overall disease activity, without a significant exercise induced flare in pain.
Clinical ScienceInhibition of Nitric Oxide Synthesis in Forearm Vasculature of Insulin-Dependent Diabetic Patients: Blunted Vasoconstriction in Patients with Microalbuminuria
214 Citations1993T. G. Elliott, J.R. Cockcroft +3 more
Evidence of abnormal endothelium-derived relaxing factor/nitric oxide biosynthesis in insulin-dependent diabetic patients with microalbuminuria is provided.
International Journal of ObesityPredictors of weight change in men: Results from The Health Professionals Follow-Up Study
211 Citations1998EH Coakley, EB Rimm +3 more
Improvement in the mix of health habits, particularly increasing vigorous activity, as well as decreasing TV use and changing eating habits, results in weight maintenance or a modest weight loss over four years.
Calcified Tissue InternationalThe effects of walking at the anaerobic threshold level on vertebral bone loss in postmenopausal women
211 Citations1993MASAKO HATORI, Akira Hasegawa +6 more
It is concluded that short-term exercise with intensity above the AT is safe and effective in preventing postmenopausal bone loss.
Diabetes CareIncreasing Physical Activity in People With Type 2 Diabetes
208 Citations2003Alison Kirk, Nanette Mutrie +2 more
Exercise consultation increased physical activity and improved glycemic control and cardiovascular risk factors in people with type 2 diabetes.
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