Early Development of Ocular Dominance Columns
SciencePublished 17 November 2000
Justin C. Crowley, Lawrence C Katz
Citations305
SJR quartileQ1
SJR score10.42
SNIP6.62
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
It is proposed that ocular dominance column formation relies on the targeting of distinct axonal populations to defined locales in cortical layer 4.
Abstract
The segregation of lateral geniculate nucleus (LGN) axons into ocular dominance columns is believed to involve a prolonged, activity-dependent sorting process. However, visualization of early postnatal ferret LGN axons by direct LGN tracer injections revealed segregated ocular dominance columns <7 days after innervation of layer 4. These early columns were unaffected by experimentally induced imbalances in retinal activity, implying that different mechanisms govern initial column formation and their modification during the subsequent critical period. Instead of activity-dependent plasticity, we propose that ocular dominance column formation relies on the targeting of distinct axonal populations to defined locales in cortical layer 4.
Keywords
NeuroscienceBiochemistry, Genetics and Molecular Biology
ScienceSynaptic Activity and the Construction of Cortical Circuits
3,067 Citations1996Lawrence C Katz, Carla J. Shatz
The sequential combination of spontaneously generated and experience-dependent neural activity endows the brain with an ongoing ability to accommodate to dynamically changing inputs during development and throughout life.
Philosophical transactions of the Royal Society of London. Series B, Biological sciencesPlasticity of ocular dominance columns in monkey striate cortex
1,659 Citations1977David H. Hubel, Torsten N. Wiesel +3 more
Preliminary experiments suggest that the layer IVC columns in juvenile macaque monkeys are not fully developed until some weeks after birth, which explains the critical period for deprivation effects in the layerIV columns.
The Journal of Comparative NeurologyThe development of ocular dominance columns in normal and visually deprived monkeys
1,133 Citations1980Simon Le Vay, Torsten N. Wiesel +1 more
The main purpose of this study was to examine the normal postnatal development of ocular dominance columns in the striate cortex of the macaque monkey and to determine how this developmental process is influenced by monocular lid‐suture.
The Journal of Comparative NeurologyLaminar and columnar distribution of geniculo‐cortical fibers in the macaque monkey
961 Citations1972David H. Hubel, Torsten N. Wiesel
The laminar distribution of axon terminals in the cortex is correlated with functional differences between layers, and the IVth‐layer mosaic anatomically is demonstrated.
Journal of NeuroscienceBinocular impulse blockade prevents the formation of ocular dominance columns in cat visual cortex
692 Citations1986Michael P. Stryker, WA Harris
Assays indicated that retinal blockade completely blocked the formation of ocular dominance columns, unlike any of the control procedures, suggesting that the spontaneous maintained discharge of retinal ganglion cells may have an important role in the normal development of binocular connections in the visual cortex.
NaturePrenatal genesis of connections subserving ocular dominance in the rhesus monkey
676 Citations1976Pasko Rakić
In foetal monkey brain neuronal projections carrying input from the two eyes initially overlap; they segregate during the second half of gestation and become fully separated in subcortical visual centres and partially separated in the cortex three weeks before birth and thus before visual experience.
ScienceOcular Dominance Column Development: Analysis and Simulation
669 Citations1989Kenneth D. Miller, Joseph B. Keller +1 more
A mathematical model of several biological mechanisms that can account for ocular dominance segregation and the resulting patch width is presented and can be used to predict the results of proposed experiments and to discriminate among various mechanisms of plasticity.
The Journal of Comparative NeurologyOcular dominance columns and their development in layer IV of the cat's visual cortex: A quantitative study
668 Citations1978Simon LeVay, Michael P. Stryker +1 more
The distribution of geniculocortical afferents serving the left and right eyes was studied in abult cats and in kittens of various ages.
ScienceThe Role of Visual Experience in the Development of Columns in Cat Visual Cortex
586 Citations1998Michael C. Crair, Deda C. Gillespie +1 more
The role of experience in the development of the cerebral cortex has long been controversial, and this work has shown that experience is essential for specific features of these maps, as well as for maintaining the responsiveness and selectivity of cortical neurons.
NatureRequirement for subplate neurons in the formation of thalamocortical connections
571 Citations1990Anirvan Ghosh, Antonella Antonini +2 more
It is shown that early in development the deletion of subplate neurons located beneath visual cortex prevents axons from the lateral geniculate nucleus of the thalamus from recognizing and innervating visual cortex, their normal target.
Brain ResearchAutoradiographic demonstration of ocular-dominance columns in the monkey striate cortex by means of transneuronal transport
437 Citations1974T. N. Wiesel, David H. Hubel +1 more
If radioactive substances were transported transneuronally, injection of labeled material into one eye followed by autoradiography of the cortex might reveal the entire system of ocular-dominance columns.
NatureAnatomical Demonstration of Columns in the Monkey Striate Cortex
379 Citations1969David H. Hubel, T. N. Wiesel
Anatomical investigation of the monkey striate cortex supports the physiological concept that the cortex is subdivided vertically into columnar aggregates of cells.
Journal of NeuroscienceSpatial Relationships among Three Columnar Systems in Cat Area 17
379 Citations1997Mark Hübener, Doron Shoham +2 more
The spatial relationships between the orientation, ocular dominance, and spatial frequency domains in cat area 17 are investigated using optical imaging of intrinsic signals to obtain high resolution maps for each of these stimulus features from the same cortical regions.
Network Computation in Neural SystemsThe development of topography in the visual cortex: a review of models
347 Citations1996Nicholas V. Swindale
Journal of NeuroscienceGeometry of orientation and ocular dominance columns in monkey striate cortex
342 Citations1993Klaus Obermayer, GG Blasdel
It is shown that ocular dominance is organized in slabs and that orientation preferences are organized in linear sequences likely to reflect slabs, and that linear zones (arising where orientation preferences change along straight axes) tend to lie at the edges of Ocular dominance columns.
Journal of NeuroscienceDevelopment of orientation selectivity in ferret visual cortex and effects of deprivation
342 Citations1993B. Chapman, Michael P. Stryker
It is concluded that the maturation of orientation-selective responses in ferret primary visual cortex requires cortical neuronal activity, and that normal development requires visually driven activity.
Journal of NeuroscienceAn adult-like pattern of ocular dominance columns in striate cortex of newborn monkeys prior to visual experience
304 Citations1996Jonathan C. Horton, D. R. Hocking
Findings indicate that stimulation of the retina by light is not necessary for the development of columnar systems in the visual cortex and that ocular dominance columns, patches, and V2 stripes all are well formed before visual experience.
Proceedings of the National Academy of SciencesRelationships between orientation-preference pinwheels, cytochrome oxidase blobs, and ocular-dominance columns in primate striate cortex.
278 Citations1992E Bartfeld, Amiram Grinvald
The relationships between cytochrome oxidase blobs, ocular-dominance columns, and iso-orientation domains, subsystems underlying visual perception, were explored in primary visual cortex of macaque monkey, revealing a radial arrangement, forming a pinwheel-like structure surrounding a singularity point.
Nature NeuroscienceDevelopment of ocular dominance columns in the absence of retinal input
273 Citations1999Justin C. Crowley, Lawrence C Katz
It is proposed that formation of ocular dominance columns relies on molecular cues present on thalamic axons, cortical cells or both, and the patterning of geniculocortical afferents resists this dramatic change in the level, source and pattern of spontaneous activity.
ScienceCorrelational Structure of Spontaneous Neuronal Activity in the Developing Lateral Geniculate Nucleus in Vivo
267 Citations1999Michael Weliky, Lawrence C Katz
Recording in the lateral geniculate nucleus of awake behaving ferrets revealed patterns of spontaneous activity that reflect a reshaping of retinal drive within higher visual stages, which emerge from interactions between retina, thalamus, and cortex.
ScienceInvolvement of Subplate Neurons in the Formation of Ocular Dominance Columns
253 Citations1992Anirvan Ghosh, Carla J. Shatz
Interactions between LGN axons and layer 4 neurons are not sufficient; subplate neurons are also required for formation of ocular dominance columns in the visual cortex.
Journal of NeuroscienceThe Critical Period for Ocular Dominance Plasticity in the Ferret’s Visual Cortex
245 Citations1999Naoum P. Issa, Joshua T. Trachtenberg +3 more
Analysis of the effects of 7 d and longer deprivations revealed a second period of plasticity in cortical responses in which MD induced an effect like that of strabismus, which was compared to other features of development in ferret and cat.
ScienceDevelopment of Visual Centers in the Primate Brain Depends on Binocular Competition Before Birth
224 Citations1981Pasko Rakić
Journal of NeuroscienceDevelopment of individual geniculocortical arbors in cat striate cortex and effects of binocular impulse blockade
222 Citations1993Antonella Antonini, Michael P. Stryker
Results reveal that sparse but widely extending branches characteristic of young arbors are eliminated during normal development at the same time as selected portions of the arbor grow considerably in length and complexity.
Journal of NeuroscienceThe Role of Activity in the Development of Long-Range Horizontal Connections in Area 17 of the Ferret
208 Citations1996Edward S. Ruthazer, Michael P. Stryker
It is concluded that the anatomical specificity of long-range horizontal connections results from an activity-dependent process that initially can use spontaneous activity in the cortical and thalamic networks to establish crude periodic connections and later uses visual cues to refine these connections.
Network Computation in Neural SystemsThe development of topography in the visual cortex: a review of models
206 Citations1996Nicholas V. Swindale
This article reviews the models of topographic organization in the visual cortex in a roughly historical sequence, beginning with von der Malsburg's paper 1973 paper in Kybernetik on self-organization of orientation selectivity.
Journal of NeuroscienceVisual cortex development in the ferret. I. Genesis and migration of visual cortical neurons
193 Citations1989Caroline Jackson, JD Peduzzi +1 more
The production of ferret visual cortical neurons was studied using 3H- thymidine autoradiography and found that Layer I neurons are generated both early (E20-E30) and late (P1-P14) in the period of cortical neurogenesis and, thus, provide at least a partial exception to the inside-out gradient of cortical Neurogenesis.
Journal of NeuroscienceDevelopmental determinants at the mammalian optic chiasm
144 Citations1995RW Guillery, CA Mason +1 more
The sequence of developmental processes that characterizes the formation of the optic chiasm provides an interesting and useful challenge to experimentalists, because the advancing axons can now be observed in vitro and in the living brain.
The Journal of Comparative NeurologyPlasticity of geniculocortical afferents following brief or prolonged monocular occlusion in the cat
139 Citations1996Antonella Antonini, Michael P. Stryker
Compared the geniculocortical connectivity in normal kittens with that following brief or prolonged periods of occlusion of vision in one eye, these findings provide further evidence for rapid, activity‐dependent remodeling of afferents during development.
European Journal of NeuroscienceUltrastructural Evidence for Synaptic Interactions between Thalamocortical Axons and Subplate Neurons
139 Citations1994Kathrin Herrmann, Antonella Antonini +1 more
Observations provide direct evidence that thalamocortical axons make synaptic contacts with subplate neurons, the only cell type within the subplate possessing mature dendrites and dendritic spines; they suggest that functional interactions between thalamic axons and sub plate neurons could play a role in the establishment of appropriate thalamOCortical connections.
ScienceRearrangements of Synaptic Connections in Visual Cortex Revealed by Laser Photostimulation
133 Citations1994Matthew B. Dalva, Lawrence C Katz
The relative influence of local connections on the activity of layer 2 and layer 3 neurons declines as the cortex matures while the influence of longer range connections increases substantially.
Cerebral CortexDevelopment of Horizontal Projections in Layer 2/3 of Ferret Visual Cortex
120 Citations1996Jeremy C. Durack, Lawrence C Katz
The ferret circuitry matures earlier than that of the cat relative to the time of eye opening, and this system of orientation-specific patches begins to develop in the absence of patterned visual input and when most cortical cells are not yet orientation selective, suggesting a prominent role for spontaneous activity in initiating cluster formation.
Current Opinion in NeurobiologyGlia, neurons, and axon pathfinding during optic chiasm development
110 Citations1997Carol A. Mason, David W. Sretavan
These interactions appear to be involved both in determining the position of the optic chiasm on the ventral diencephalon and in ipsilateral and contralateral RGC axon pathfinding, development events fundamental to binocular vision in the adult animal.
Journal of NeurophysiologyOcular Dominance Peaks at Pinwheel Center Singularities of the Orientation Map in Cat Visual Cortex
107 Citations1997Michael C. Crair, Edward S. Ruthazer +2 more
It is reported here that in cats there is a strong tendency for peaks of ocular dominance to lie on the pinwheel center singularities of the orientation map, which predicts but is not predicted by the tendencies for pinwheels to lie near the center lines of Ocular dominance bands.
ScienceNecessity for Afferent Activity to Maintain Eye-Specific Segregation in Ferret Lateral Geniculate Nucleus
106 Citations2000Barbara Chapman
Results show that an activity-dependent process is necessary for maintaining eye-specific segregation and suggest that activity-independent cues may favor lamina A as the target for arborization of afferents from both eyes.
NatureOcular dominance shift in kitten visual cortex caused by imbalance in retinal electrical activity
90 Citations1986Barbara Chapman, Michael D. Jacobson +2 more
It is indicated that patterned vision is not necessary for visual cortical plasticity, and that an imbalance in spontaneous retinal activity alone can produce a significant ocular dominance shift.
Journal of NeuroscienceCorrelation-Based Development of Ocularly Matched Orientation and Ocular Dominance Maps: Determination of Required Input Activities
89 Citations1998Ed Erwin, Kenneth D. Miller
The model’s main prediction is that the above correlations should exist among inputs to cortical layer 4 simple cells before vision, and mature simple cells are predicted to have certain relationships between the locations of the ON and OFF subregions of the left and right eyes’ receptive fields.
Journal of NeurophysiologySegregation of ON and OFF afferents to ferret visual cortex
82 Citations1988Kathleen R. Zahs, Michael P. Stryker
Surface-mapping results and the results of experiments in which electrode penetrations were made tangential to layer IV indicated that center- type patches can extend over several hundred micrometers, and a Monte Carlo analysis of the sizes of the ocular dominance patches and center-type patches provided further support for this conclusion.
Journal of NeuroscienceMaps of Central Visual Space in Ferret V1 and V2 Lack Matching Inputs from the Two Eyes
78 Citations1999Leonard White, William H. Bosking +2 more
It is suggested that both the monocularity of these cortical maps and the visuotopic discontinuity along the V1–V2 border derive from asymmetries in the crossed and uncrossed retinal pathways.
NeuronEmergence of functional circuits in ferret visual cortex visualized by optical imaging
75 Citations1995D. A. Nelson, Lawrence C Katz
Results indicate that functional horizontal interactions emerge only after axons begin branching and in parallel with, but not prior to, the refinement of orientation selectivity.
Proceedings of the National Academy of SciencesEarly divergence of magnocellular and parvocellular functional subsystems in the embryonic primate visual system
68 Citations1997Claire Meissirel, Kenneth C. Wikler +2 more
Evidence is provided that retinal ganglion cells in the macaque monkey embryo diverge into M and P subtypes soon after their last mitotic division and that optic axons project directly and selectively to either the M or P moieties of the developing lateral geniculate nucleus.
Visual NeuroscienceEffect of early monocular enucleation upon ocular dominance columns and cytochrome oxidase activity in monkey and human visual cortex
55 Citations1998Jonathan C. Horton, Davina R. Hocking
CO histochemistry accurately labels the boundaries of columns in layer IVcβ of macaque striate cortex after early monocular enucleation, making it a suitable technique for defining the critical period for plasticity of ocular dominance columns in human Striate cortex.
Journal of NeuroscienceEstablishment of Patterned Thalamocortical Connections Does Not Require Nitric Oxide Synthase
48 Citations1998Eva M. Finney, Carla J. Shatz
Despite the dynamic regulation of NOS in subplate neurons, NO is unlikely to be essential for the patterning of thalamocortical connections either in visual or somatosensory systems.
The Journal of Comparative NeurologyDevelopment and organization of ocular dominance bands in primary visual cortex of the sable ferret
45 Citations1999Edward S. Ruthazer, Gary E. Baker +1 more
The development of ocular dominance bands was studied by transneuronal labeling of the visual cortices of ferret kits between the ages of postnatal day 28 and P81 after intravitreous injections of either tritiated proline or wheat germ agglutinin‐horseradish peroxidase.
Journal of NeuroscienceFunctional organization in the ferret visual cortex: a double-label 2- deoxyglucose study
37 Citations1990Christoph Redies, Mirko Dikšić +1 more
The functional organization of visual cortical area 17/18 of the ferret was studied using a double-label 2-deoxyglucose (2-DG) method and eye dominance in the binocular segment of both areas 17 and 18 was found to be organized into elongated ipsilateral islands in an almost contiguous contralateral projection.
NeuroreportEarly postnatal development of functional ocular dominance columns in cat primary visual cortex
20 Citations2000Stefan Rathjen, Siegrid Löwel
It is hypothesize that a small and anatomically undetectable imbalance between the afferents from the two eyes is amplified by intracortical interactions so that their activity patterns become different and may guide the segregation process of the Afferents in cortical layer IV.