Strand breaks of mammalian mitochondrial DNA induced by carcinogens
Chemico-Biological InteractionsPublished 1 June 1977
Michiko Miyaki, Kazuko Yatagai, Tetsuo Ono
Citations41
SJR quartileQ1
SJR score1.12
SNIP1.11
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TL;DR
Mitochondrial DNA damaged by carcinogens was not repaired during 4-20 h of post-treatment incubation of the cells and incorporation of labeled thymidine into the closed circular mitochondrial DNA, decreased by the treatment of cells with carcinogens, recovered during post- treatment incubation.
Abstract
Closed circular mitochondrial DNA in mammalian cells was degradated to the open circular form by exposure of the cells to the carcinogens N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and 4-nitroquinoline 1-oxide (4NQO). MNNG caused more strand scission of mitochondrial DNA than 4NQO at the same concentration. The action of the carcinogens on mitochondrial DNA did not parallel that with nuclear DNA which was damaged by 4NQO more markedly than by MNNG. Mitochondrial DNA damaged by carcinogens was not repaired during 4-20 h of post-treatment incubation of the cells. Incorporation of labeled thymidine into the closed circular mitochondrial DNA, decreased by the treatment of cells with carcinogens, recovered during post-treatment incubation.
Keywords
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