Interaktionseffekte Monoamin-relevanter genetischer Polymorphismen mit Traits des TPQ
Zeitschrift für Differentielle und Diagnostische PsychologiePublished 1 September 2000
Alexander Strobel, Burkhard Brocke, Richard P. Ebstein
Citations7
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Abstract
Zusammenfassung: Fortschritte in der Molekulargenetik ermöglichen es, den Erklärungsbeitrag genetischer Polymorphismen mit funktioneller Relevanz zum genetischen Hintergrund der Erblichkeitskomponente einiger Persönlichkeitstraits zu untersuchen. Bisherige Befunde sprechen für potentielle Assoziationen eines Polymorphismus im Dopamin-D4-Rezeptor-Gen (DRD4 Exon 3) mit der Dimension Novelty Seeking (NS) des Tridimensional Personality Questionnaire (TPQ) sowie eines Polymorphismus des Serotonin-Transporter-Gens (5-HTTLPR) mit TPQ Harm Avoidance (HA). Die Betrachtung von Interaktionen dieser Polymorphismen kann einen Beitrag zur Klärung von Inkonsistenzen in bisherigen Assoziationsstudien leisten. In der vorliegenden Arbeit wurden für 134 Personen Interaktionen von DRD4 Exon 3 und 5-HTTLPR sowie einem Polymorphismus des Gens für COMT auf die Faktorwerte der TPQ-Subskalen überprüft. Es zeigten sich Tendenzen zu Interaktionen zwischen DRD4 Exon 3 und 5-HTTLPR bei dem HA-Faktor sowie zwischen DRD4 Exon 3 und dem COMT-Polymorphismus bei dem NS-Faktor.
Keywords
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