Functional and pathophysiological models of the basal ganglia
Current Opinion in NeurobiologyPublished 1 December 1996
Thomas Wichmann, Mahlon R. DeLong
Citations735
SJR quartileQ1
SJR score2.54
SNIP1.27
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TL;DR
Because of new data, anatomical and functional models of the basal ganglia in normal and pathological conditions (e.g. Parkinson's and Huntington's diseases) have recently come under greater scrutiny and an update of these models is clearly timely.
Abstract
Because of new data, anatomical and functional models of the basal ganglia in normal and pathological conditions (e.g. Parkinson's and Huntington's diseases) have recently come under greater scrutiny. An update of these models is clearly timely, taking into consideration not only changes in neuronal discharge rates, but also changes in the patterning and synchronization of neuronal discharge, the role of extrastriatal dopamine, and expanded intrinsic and input/output connections of these nuclei.
Keywords
MedicineNeuroscience
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The data presented in this report further support the concept on functional and anatomical diversity of the subdivisions of the primate motor thalamus proposed in 1990 by Hinsky.
Brain ResearchExcitotoxic lateral pallidotomy does not relieve L-DOPA-induced dyskinesia in MPTP parkinsonian monkeys
48 Citations1994Pierre J. Blanchet, R. Boucher +1 more
The fact that ablation of the GPL worsened LID suggests that a complex rearrangement of the balance of functional capacity between the GP and the subthalamic nucleus takes place in LID which is not amenable to correction merely by a lateral pallidotomy.
Journal of NeuroscienceRepeated treatment with haloperidol and clozapine exerts differential effects on dye coupling between neurons in subregions of striatum and nucleus accumbens
44 Citations1995SP Onn, AA Grace
The finding that both APDs exert a common action on neurons in the accumbens shell region is consistent with its identification as the site of therapeutic drug actions, whereas the capacity of haloperidol to also affect cells in the motor-related matrix and core regions correlates with its high propensity to induce extrapyramidal side effects.
Clinical NeuropharmacologyDopamine Receptor Function in the Basal Ganglia
39 Citations1995Charles R. Gerfen
Fundamental and Clinical PharmacologyIs striatal dopaminergic receptor imbalance responsible for levodopa‐induced dyskinesia?
27 Citations1995PJ Blanchet, Baltazar Gomez‐Mancilla +2 more
The hypothesis that more continuous forms of dopaminomimetic therapy represent the best therapeutic approach for Parkinson's disease is supported and calls for the development of novel D1 agonists for further clinical testing.
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