Nitrata and Human Cancer: A Review of the Evidence
International Journal of EpidemiologyPublished 1 January 1980
P. M. Fraser, Clair Chilvers, Valerie Beral, Michael J. Hill
Citations127
SJR quartileQ1
SJR score2.69
SNIP2.48
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TL;DR
The mechanism of their formation and the evidence from epidemiological studies that high nitrate ingestion is involved in the aetiology of human cancer are reviewed.
Abstract
Nitrites, derived mainly from ingested nitrates, may react in vivo with secondary nitrogen compounds occurring naturally in certain foods to form N-nitroso compounds, which are potent carcinogens in laboratory animals. This paper reviews the mechanism of their formation and the evidence from epidemiological studies that high nitrate ingestion is involved in the aetiology of human cancer.
Keywords
Biochemistry, Genetics and Molecular Biology